Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Radhakrishna Vakkalanka"'
Autor:
Lucas Kempf, Kristin K Nicodemus, Bhaskar Kolachana, Radhakrishna Vakkalanka, Beth A Verchinski, Michael F Egan, Richard E Straub, Venkata A Mattay, Joseph H Callicott, Daniel R Weinberger, Andreas Meyer-Lindenberg
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000252 (2008)
PRODH, encoding proline oxidase (POX), has been associated with schizophrenia through linkage, association, and the 22q11 deletion syndrome (Velo-Cardio-Facial syndrome). Here, we show in a family-based sample that functional polymorphisms in PRODH a
Externí odkaz:
https://doaj.org/article/f5a0dd74f24b40efab11dfae81443706
Autor:
Richard E. Straub, Radhakrishna Vakkalanka, Ningping Feng, Chao Li, Daniel R. Weinberger, Alessandro Bertolino, Bhaskar Kolachana, Giovanna Todarello
Publikováno v:
Schizophrenia Research. 155:1-7
Neurexin 1 (NRXN1) is a presynaptic neuronal adhesion molecule that interacts with postsynaptic neuroligins in both glutamatergic and GABAergic synapses and is important in synaptic formation and function. NRXN1 deletions increase the risk of schizop
Autor:
Craig J. Thomas, Wenwei Huang, Joel E. Kleinman, Radhakrishna Vakkalanka, Richard E. Straub, Patricio O'Donnell, Barbara K. Lipska, Thomas M. Hyde, Paul Harrison, Daniel R. Weinberger, Amanda J. Law, Yanhong Wang, Patrick T. Piantadosi, Aaron D. Besterman, Yoshitatsu Sei, Francesco Papaleo
Neuregulin 1 (NRG1) and ErbB4, critical neurodevelopmental genes, are implicated in schizophrenia, but the mediating mechanisms are unknown. Here we identify a genetically regulated, pharmacologically targetable, risk pathway associated with schizoph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bdaf636eb476b699b16dca71f123175
https://doi.org/10.1073/pnas.1206118109
https://doi.org/10.1073/pnas.1206118109
Autor:
Daniel R. Weinberger, Ina Giegling, Barbara K. Lipska, Dan Rujescu, Radhakrishna Vakkalanka, Pierandrea Muglia, David St Clair, Yin Yao Shugart, Kristin K. Nicodemus, Augustin Luna, Joseph H. Callicott, Rachel G. Higier, Devon C. Nixon
Publikováno v:
Human Genetics. 127:441-452
The etiology of schizophrenia likely involves genetic interactions. DISC1, a promising candidate susceptibility gene, encodes a protein which interacts with many other proteins, including CIT, NDEL1, NDE1, FEZ1 and PAFAH1B1, some of which also have b
Autor:
Richard E. Straub, Peter Schmidt, Daniel R. Weinberger, David R. Rubinow, Catherine A. Roca, Kai Shi, Radhakrishna Vakkalanka, Liang Huo
Publikováno v:
Biological Psychiatry. 62:925-933
Background Premenstrual dysphoric disorder (PMDD) is a heritable mood disorder that is triggered by gonadal steroids during the luteal phase in susceptible women. Methods We performed haplotype analyses of estrogen receptors alpha and beta (ESR1 and
Autor:
Steven Sust, Daniel R. Weinberger, Beth A. Verchinski, Venkata S. Mattay, Michael F. Egan, Richard E. Straub, Joshua W. Buckholtz, Robyn A. Honea, Radhakrishna Vakkalanka, Joseph H. Callicott, Lukas Pezawas, Andreas Meyer-Lindenberg, Bhaskar Kolachana
Publikováno v:
The Journal of Neuroscience. 27:1584-1593
Regulator of G-protein signaling 4 (RGS4) modulates postsynaptic signal transduction by affecting the kinetics of Gα-GTP binding. Linkage, association, and postmortem studies have implicated the gene encoding RGS4 (RGS4) as a schizophrenia susceptib
Autor:
Richard E. Straub, Dede Greenstein, Natalie Baker, D.R. Weinberger, Alexandra Sporn, Judith L. Rapoport, Aaron J. Bobb, Radhakrishna Vakkalanka, Peter Gochman, Michele C. Gornick, Nitin Gogtay, J Duckworth, Marge Lenane, Rishi Balkissoon, Anjené M. Addington
Publikováno v:
Molecular Psychiatry. 10:581-588
Postmortem brain studies have shown deficits in the cortical gamma-aminobutyric acid (GABA) system in schizophrenic individuals. Expression studies have shown a decrease in the major GABA-synthesizing enzyme (glutamic acid decarboxylase (GAD67) mRNA
Autor:
Joseph H. Callicott, Venkata S. Mattay, Amanda J. Law, Roberta Rasetti, Heike Tost, Daniel R. Weinberger, Radhakrishna Vakkalanka
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience. 34(3)
The neuregulin 3 gene (NRG3) plays pleiotropic roles in neurodevelopment and is a putative susceptibility locus for schizophrenia. Specifically, the T allele ofNRG3rs10748842 has been associated with illness risk, altered cognitive function, and the
Autor:
Kristin K. Nicodemus, Radhakrishna Vakkalanka, Joel E. Kleinman, Daniel R. Weinberger, Amanda J. Law, Augustin Luna, Richard E. Straub
Publikováno v:
Molecular Psychiatry. 14:741-743
NRG1 is a schizophrenia candidate gene which regulates brain development and neural function. The minor allele of rs7014762 in the NRG1 5′ core promoter was associated with schizophrenia (p=0.031) and significant predicted reduced NRG1 Type III iso
Autor:
David St Clair, Joel E. Kleinman, Dan Rujescu, Fengyu Zhang, Radhakrishna Vakkalanka, Qiang Chen, Daniel R. Weinberger, Barbara K. Lipska, Richard E. Straub, Thomas M. Hyde, Llewellyn B. Bigelow, Tianzhang Ye
Publikováno v:
Biological psychiatry. 69(10)
Background The single nucleotide polymorphism (SNP) rs1344706 in ZNF804A (2q32.1) has been associated with schizophrenia in a genome-wide association study (GWAS). A recent candidate gene study, which replicated the positive association with rs134470