Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Radhakrishna Sura"'
Autor:
Kyathanahalli S. Janardhan, Radhakrishna Sura, Smita Salian-Mehta, Thierry Flandre, Xavier Palazzi, Doris Zane, Bhanu Singh, Binod Jacob, Renee Rosemary Hukkanen, Muthafar Al-Haddawi, Bindu Bennet, Victoria Laast, Donna Lee, Richard Peterson, Annette Romeike, Frederic Schorsch, Magali Guffroy
Publikováno v:
Toxicologic pathology. 50(8)
Nonclinical toxicology studies that are required to support human clinical trials of new drug candidates are generally conducted in a rodent and a non-rodent species. These studies typically contain a vehicle control group and low, intermediate, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2273f2dc43a1f87ae26f6ebf23230e3
https://pubmed.ncbi.nlm.nih.gov/36226581
https://pubmed.ncbi.nlm.nih.gov/36226581
Autor:
Radhakrishna Sura, Jonathan Werner, Molly H. Boyle, Christopher Houle, Begonya Garcia, Bindu Bennet, Annette Romeike, Karyn Colman, Anna-Lena Frisk, Susan A. Elmore
Publikováno v:
Toxicol Pathol
Toxicologic Pathology is the official journal of the Society of Toxicologic Pathology (STP), the British Society of Toxicological Pathology (BSTP), and the European Society of Toxicologic Pathology (ESTP). Toxicologic Pathology publishes articles rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fda5fe770e72e941c75c7c39e68ea6
https://doi.org/10.1177/0192623321992305
https://doi.org/10.1177/0192623321992305
Autor:
Jean-Charles Gautier, Myrtle Davis, Douglas A. Keller, Niresh Hariparsad, Jonathan A. Phillips, Radhakrishna Sura, Taraka Sai Pavan Grandhi, Terry R. Van Vleet
Publikováno v:
Lab on a Chip. 20:468-476
The human kidney contains approximately one million nephrons. As the functional unit of the kidney, the nephron affords an opportunity to approximate the kidney at a microphysiological scale. Recent emergence of physiologically accurate human tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de840a616151794554b2a7cfe1beb0ca
https://doi.org/10.1039/c9lc00925f
https://doi.org/10.1039/c9lc00925f
Autor:
Jessica Whritenour, Rhiannon N. Hardwick, Catherine J. Betts, Maike Thamsen, Radhakrishna Sura, Kristin M. Fabre, Elad H. Kaufman
Publikováno v:
Lab on a Chip. 20:199-214
Skin is the largest organ of the body and serves as the principle barrier to the environment. Composed of multiple cell types arranged in stratified layers with highly specialized appendages, it serves sensory and immune surveillance roles in additio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80dfc071343eaf8f78bad1d63f87da94
https://doi.org/10.1039/c9lc00519f
https://doi.org/10.1039/c9lc00519f
Autor:
Szczepan W, Baran, Paul C, Brown, Andreas R, Baudy, Suzanne C, Fitzpatrick, Christopher, Frantz, Aaron, Fullerton, Jinping, Gan, Rhiannon N, Hardwick, Kathleen M, Hillgren, Anna K, Kopec, Jennifer L, Liras, Donna L, Mendrick, Ryan, Nagao, William R, Proctor, Diane, Ramsden, Alexandre J S, Ribeiro, David, Stresser, Kyung E, Sung, Radhakrishna, Sura, Kazuhiro, Tetsuka, Lindsay, Tomlinson, Terry, Van Vleet, Matthew P, Wagoner, Qin, Wang, Sevim Yildiz, Arslan, Gorm, Yoder, Jason E, Ekert
Publikováno v:
ALTEX.
Complex in vitro models (CIVM) offer the potential to improve pharmaceutical clinical drug attrition due to safety and/ or efficacy concerns. For this technology to have an impact, the establishment of robust characterization and qualification plan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::991b82190055f9a932fb29fb1692bafd
https://doi.org/10.14573/altex.2112203
https://doi.org/10.14573/altex.2112203
Publikováno v:
Toxicologic pathology. 49(5)
Nonclinical evaluation of human safety risks for new chemical entities (NCEs) is primarily conducted in conventional healthy animals (CHAs); however, in certain instances, animal models of diseases (AMDs) can play a critical role in the understanding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0ef6a009b8b282f2331fcef266c7d48
https://pubmed.ncbi.nlm.nih.gov/33827334
https://pubmed.ncbi.nlm.nih.gov/33827334
Autor:
Thomas K. Baker, Radhakrishna Sura, Josesph Cichocki, David M Stresser, Paul Levesque, Diane Ramsden, Myrtle Davis, Gary A. Gintant, Christopher M. Hale, Jonathan Maher, Amy Pointon, Kyle L. Kolaja
Publikováno v:
Lab on a chip. 21(3)
The integrative responses of the cardiovascular (CV) system are essential for maintaining blood flow to provide oxygenation, nutrients, and waste removal for the entire body. Progress has been made in independently developing simple in vitro models o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c58ac64ab0b3f6fceab193d783353528
https://pubmed.ncbi.nlm.nih.gov/33471007
https://pubmed.ncbi.nlm.nih.gov/33471007
Autor:
Allison Laura Choy, Douglas A. Keller, Matthew F. Peters, Carmen Pin, Kyle L. Kolaja, Radhakrishna Sura, Lorna Ewart, Peggy Guzzie-Peck, Clay W Scott, Derek J. Leishman, Annie Moisan
Publikováno v:
Lab on a chip. 20(7)
Drug-induced gastrointestinal toxicities (DI-GITs) are among the most common adverse events in clinical trials. High prevalence of DI-GIT has persisted among new drugs due in part to the lack of robust experimental tools to allow early detection or t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e320538b399417dfcaef5a1cd406a78a
https://pubmed.ncbi.nlm.nih.gov/32129356
https://pubmed.ncbi.nlm.nih.gov/32129356
Autor:
Christina M. Dunville, Ekmay Ricardo, Johnson Thomas, Jennifer A. Murray, Sabitha Papineni, Radhakrishna Sura
Publikováno v:
Food and Chemical Toxicology. 109:245-252
A 90-day sub chronic toxicity study was conducted in rats to evaluate the safety of genetically modified DAS-444Ø6-6 soybeans expressing herbicide tolerant proteins when compared with its conventional comparators (non-transgenic near isoline control
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecd59d6200fd241af08c39a005d2a433
https://doi.org/10.1016/j.fct.2017.08.048
https://doi.org/10.1016/j.fct.2017.08.048
Autor:
Douglas A. Keller, Brian R. Berridge, Ananthsrinivas Chakilam, Yvonne Will, Monicah A. Otieno, Kristin M. Fabre, David B. Duignan, Yvonne P. Dragan, Lorna Ewart, Terry R. Van Vleet, Danilo A. Tagle, Claire G. Jeong, Jinping Gan, Peggy Guzzie-Peck, Jonathan A. Phillips, Jeetu Eswaraka, Sonia M. de Morais, David E. Watson, Radhakrishna Sura, William R Proctor
Publikováno v:
Experimental Biology and Medicine. 242:1579-1585
Tissue chips are poised to deliver a paradigm shift in drug discovery. By emulating human physiology, these chips have the potential to increase the predictive power of preclinical modeling, which in turn will move the pharmaceutical industry closer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3128a14f0b4ce35a220ee4e7ecd5eeff
https://doi.org/10.1177/1535370217715441
https://doi.org/10.1177/1535370217715441