Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Radha Uppala"'
Autor:
Yuxun Zhang, Sivakama S Bharathi, Matthew J Rardin, Radha Uppala, Eric Verdin, Bradford W Gibson, Eric S Goetzman
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0122297 (2015)
SIRT3 and SIRT5 have been shown to regulate mitochondrial fatty acid oxidation but the molecular mechanisms behind the regulation are lacking. Here, we demonstrate that SIRT3 and SIRT5 both target human very long-chain acyl-CoA dehydrogenase (VLCAD),
Externí odkaz:
https://doaj.org/article/3d38874a45974e22a5536a51a6487733
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e106028 (2014)
SIRT3, SIRT4, and SIRT5 are mitochondrial deacylases that impact multiple facets of energy metabolism and mitochondrial function. SIRT3 activates several mitochondrial enzymes, SIRT4 represses its targets, and SIRT5 has been shown to both activate an
Externí odkaz:
https://doaj.org/article/0da267d9c0154393871644169739e70c
Autor:
Radha Uppala, Megan E. Beck, Sivakama S. Bharathi, Brianne Dudiak, Donna B. Stolz, Yuxun Zhang, Eric S. Goetzman
Publikováno v:
Biochemical and Biophysical Research Communications. 482:346-351
The metabolic effects of salicylates are poorly understood. This study investigated the effects of aspirin on fatty acid oxidation. Aspirin increased mitochondrial long-chain fatty acid oxidation, but inhibited peroxisomal fatty acid oxidation, in tw
Autor:
Olga Ilkayeva, Radha Uppala, Eric S. Goetzman, Sivakama S. Bharathi, Matthew D. Hirschey, John F. Alcorn, Kevin McHugh, Ye Zou, Jieru Wang, Yi Y. Zuo, Chikara Otsubo, Dongning Wang
Publikováno v:
Journal of Biological Chemistry. 290:23897-23904
The role of mitochondrial energy metabolism in maintaining lung function is not understood. We previously observed reduced lung function in mice lacking the fatty acid oxidation enzyme long-chain acyl-CoA dehydrogenase (LCAD). Here, we demonstrate th
Publikováno v:
Biochemical and biophysical research communications. 463(4)
Nickel exposure is associated with changes in cellular energy metabolism which may contribute to its carcinogenic properties. Here, we demonstrate that nickel strongly represses mitochondrial fatty acid oxidation—the pathway by which fatty acids ar
Autor:
Holger Prokisch, Birgit Haberberger, Eric S. Goetzman, Radha Uppala, Yudong Wang, Al-Walid Mohsen, Edward V. Prochownik, Jung-Ja P. Kim, Anuradha Karunanidhi, Dolly Prabhu, Arnold Munnich, Johannes Häberle, Agnès Rötig, Yuxun Zhang, Robert W. Taylor, Robert D. Nicholls, Hana Alharbi, Chuanwu Xia, Tobias B. Haack, Manuel Schiff, Jerry Vockley
Publikováno v:
Hum. Mol. Genet. 24, 3238-3247 (2015)
BASE-Bielefeld Academic Search Engine
BASE-Bielefeld Academic Search Engine
Acyl-CoA dehydrogenase 9 (ACAD9) is an assembly factor for mitochondrial respiratory chain Complex I (CI), and ACAD9 mutations are recognized as a frequent cause of CI deficiency. ACAD9 also retains enzyme ACAD activity for long-chain fatty acids in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd9d3c1ba8fc6207b418438080b3840b
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=43518
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=43518
Autor:
Jie Lu, Radha Uppala, Huabo Wang, Sucheta Kulkarni, Eric S. Goetzman, Sivakama S. Bharathi, Edward V. Prochownik, Laura E. Jackson, Mulchand S. Patel
Publikováno v:
Cancer Research. 77:445-445
Virtually all tumors undergo some form of metabolic re-programming to match anabolic needs with energy supply. The best-known form of this is the Warburg effect by which tumors become more reliant on glycolysis over mitochondrial oxidative phosphoryl
Autor:
Megan E. Beck, Eric S. Goetzman, Donald K. Scott, Audry Kang, Lokendra Kumar Sharma, Jerry Vockley, Edward V. Prochownik, Lia R. Edmunds, Shrabani Basu, Radha Uppala, Jie Lu
myc(-/-) rat fibroblasts (KO cells) differ from myc(+/+) (WT) cells and KO cells with enforced Myc re-expression (KO-Myc cells) with respect to mitochondrial structure and function, utilization of glucose and glutamine as energy-generating substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf1f973952e143852a62f43aa94e3a3d
https://europepmc.org/articles/PMC4155699/
https://europepmc.org/articles/PMC4155699/
Autor:
Virtu Calabuig-Navarro, Eric S. Goetzman, Sojin Lee, H. Henry Dong, Ann R Piccirillo, Dae Hyun Kim, Jun Yamauchi, Radha Uppala, Yong Fan, Ting Zhang
Publikováno v:
Endocrinology. 155(4)
Excessive production of triglyceride-rich very low-density lipoproteins (VLDL-TG) contributes to hypertriglyceridemia in obesity and type 2 diabetes. To understand the underlying mechanism, we studied hepatic regulation of VLDL-TG production by (fork
Autor:
Daniel Mulhern, Radha Uppala, Timothy Riiff, John C. Newman, Bradford W. Gibson, Lei Zhu, Robert Stevens, Wenjuan He, Alexandria K. Sahu, Eric Verdin, Philipp Gut, Matthew P. Jacobson, Yuya Nishida, Christopher B. Newgard, Chris Carrico, Steven R. Danielson, Eric S. Goetzman, Mark Fitch, Marc K. Hellerstein, Biao Li, Ailan Guo, Matthew J. Rardin, Jing Zhou, Olga Ilkayeva
Publikováno v:
Cell metabolism, vol 18, iss 6
SummaryReversible posttranslational modifications are emerging as critical regulators of mitochondrial proteins and metabolism. Here, we use a label-free quantitative proteomic approach to characterize the lysine succinylome in liver mitochondria and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3953d7e3d4a2eb3c49e07d413fdda4
https://europepmc.org/articles/PMC4105152/
https://europepmc.org/articles/PMC4105152/