Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Radha Ramesh"'
Autor:
Tian Zhang, Filippo de Braud, Taito Esaki, Wallace Akerley, Chrisann Kyi, Richard D Carvajal, Daniel Gusenleitner, Patrick Schöffski, Miguel Martin, David S Hong, Amy Prawira, Jürgen Krauß, Nidhi Patel, Rina Hui, Andrew Weickhardt, Niladri Roy Chowdhury, Daniel S W Tan, María Ochoa-de-Olza, John Sarantopoulos, Ross A Soo, Michela Maur, Barbara Deschler-Baier, Allen Lau, Tanay S Samant, Tyler Longmire, Catherine A Sabatos-Peyton, Radha Ramesh, Tiancen Hu, Ana Carion, Padmaja Yerramilli-Rao, Vasileios Askoxylakis, Eunice L Kwak
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 2 (2022)
Externí odkaz:
https://doaj.org/article/c14ae2c468844f0d8af45992b1b6b8f2
Autor:
Simone Bonazzi, Eva d’Hennezel, Rohan E.J. Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun C. Bhang, Roxana García Caro, Jennifer S. Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles A. Wartchow, Matthew C. Clifton, Ry R. Forseth, Bethany Hughes Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel M. Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew J. Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine A. Sabatos-Peyton, Natalie A. Dales, Frédéric J. Zécri, Rishi K. Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffery A. Porter, John A. Tallarico, Jeffrey A. Engelman, Glenn Dranoff, James E. Bradner, Michael Visser, Jonathan M. Solomon
Publikováno v:
Cell Chemical Biology. 30:235-247.e12
Autor:
Jonathan Solomon, Simone Bonazzi, Eva d'Hennezel, Rohan Beckwith, Lei Xu, Aleem Fazal, Anna Magracheva, Radha Ramesh, Artiom Cernijenko, Brandon Antonakos, Hyo-eun Bhang, Roxana Garcia Caro, Jennifer Cobb, Elizabeth Ornelas, Xiaolei Ma, Charles Wartchow, Matt Clifton, Ry Forseth, Bethany Fortnam, Hongbo Lu, Alfredo Csibi, Jennifer Tullai, Seth Carbonneau, Noel Thomsen, Jay Larrow, Barbara Chie-Leon, Dominik Hainzl, Yi Gu, Darlene Lu, Matthew Meyer, Dylan Alexander, Jacqueline Kinyamu-Akunda, Catherine Sabatos-Peyton, Natalie Dales, Frederic Zecri, Rishi Jain, Janine Shulok, Y. Karen Wang, Karin Briner, Jeffrey Porter, John Tallarico, Jeffrey Engelman, Glenn Dranoff, Jay Bradner, Michael Visser
Growing malignant tumors must evade destruction by the immune system, a hurdle some malignancies overcome by attracting immune-suppressive regulatory T-cells (Tregs)1. The IKZF2 (Helios) transcription factor plays a crucial role in maintaining functi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e91b1b99fea2c930f908b107802a0e27
https://doi.org/10.21203/rs.3.rs-1531006/v1
https://doi.org/10.21203/rs.3.rs-1531006/v1
Autor:
Stephanie Schwartz, Nidhi Patel, Tyler Longmire, Pushpa Jayaraman, Xiaomo Jiang, Hongbo Lu, Lisa Baker, Janelle Velez, Radha Ramesh, Anne-Sophie Wavreille, Melanie Verneret, Hong Fan, Tiancen Hu, Fangmin Xu, John Taraszka, Marc Pelletier, Joy Miyashiro, Mikael Rinne, Glenn Dranoff, Catherine Sabatos-Peyton, Viviana Cremasco
Publikováno v:
Immunotherapy Advances. 2
Objectives Sabatolimab is a humanized monoclonal antibody (hIgG4, S228P) directed against human T-cell immunoglobulin domain and mucin domain-3 (TIM-3). Herein, we describe the development and characterization of sabatolimab. Methods Sabatolimab was
Autor:
Hussein Abdul-Hassan Tawbi, Victoria Atkinson, Paul Nathan, Naoya Yamazaki, Radha Ramesh, Daniel Gusenleitner, Paolo A. Ascierto, Céleste Lebbé, Eduard Gasal, Dirk Schadendorf, Reinhard Dummer, Caroline Robert, Jan C. Brase, Keith T. Flaherty, Georgina V. Long, Mario Mandalà, Antoni Ribas, Kelly Biette, Erika Richtig, Ana Arance
10034 Background: Spartalizumab + dabrafenib + trametinib has previously shown a high response rate of 78% (28 of 36 pts), with a complete response (CR) rate of 42%. A correlative analysis of gene expression signatures (GES)/pathways using whole-tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4427df5cbb6f0c621237dae3895445f3
Autor:
Lisa A. Orband-Miller, Erkan Baloglu, Jianfei Yang, Ashley A. Barnes, Jill Skepner, Thaddeus J. Carlson, Darby Schmidt, Mark S. Sundrud, Shomir Ghosh, Mercedes Lobera, Jonathan Hill, Radha Ramesh, Mohamed Boudjelal, Mark Trocha
Publikováno v:
The Journal of Immunology. 192:2564-2575
IL-17–producing CD4+Th17 cells, CD8+Tc17 cells, and γδ T cells play critical roles in the pathogenesis of autoimmune psoriasis. RORγt is required for the differentiation of Th17 cells and expression of IL-17. In this article, we describe a novel
Autor:
Derya Unutmaz, Lina Kozhaya, Jacob L. McCauley, Kelly McKevitt, Ivana M. Djuretic, Maria T. Abreu, Mark S. Sundrud, Radha Ramesh, Maria A. Quintero, Thaddeus J. Carlson
Publikováno v:
The Journal of Experimental Medicine
Inflammatory T helper 17 cells in humans are distinguished by selective expression of MDR1 and are enriched in the gut of patients with Crohn’s disease.
IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of a
IL-17A–expressing CD4+ T cells (Th17 cells) are generally regarded as key effectors of a
Autor:
Ivana M. Djuretic, Thaddeus J. Carlson, Derya Unutmaz, Qi Wan, Lina Kozhaya, Mark S. Sundrud, Aimee ElHed, Radha Ramesh
Publikováno v:
The Journal of Experimental Medicine
PI-3K–mediated repression of FOXO1 and KLF2 promotes proinflammatory cytokine expression by lineage-committed human CCR6+ Th17/Th22 memory cells.
Human memory T cells (TM cells) that produce IL-17 or IL-22 are currently defined as Th17 or Th22
Human memory T cells (TM cells) that produce IL-17 or IL-22 are currently defined as Th17 or Th22
Autor:
Radha Ramesh, Barbara S. Slusher, Gregory D. Wands, Min Yang, Thomas M. Luby, Mary Lynne Hedley, Christine M. Barbon
Publikováno v:
Cellular Immunology. 262:150-161
Cyclophosphamide in combination with immunotherapeutic approaches preferentially impinges on Treg activity and allows for robust generation of T cell effectors. Reduced dosages of cyclophosphamide are necessary to restrict its cytotoxic effects to th
In vivo regulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists
Autor:
Jill Skepner, Erkan Baloglu, Jonathan Hill, Mark Trocha, Mark S. Sundrud, Xiaoyan Qu, Michael A. Nolan, Radha Ramesh, Jianfei Yang, Scott Davis, Shomir Ghosh, Thaddeus J. Carlson, Darby Schmidt, Mercedes Lobera
Publikováno v:
Immunology. 145(3)
The orphan nuclear receptor, retinoic acid receptor-related orphan nuclear receptor γt (RORγt), is required for the development and pathogenic function of interleukin-17A-secreting CD4(+) T helper type 17 (Th17) cells. Whereas small molecule RORγt