Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Radha Karki"'
Autor:
Pritam Thapa, Mengjie Li, Radha Karki, Moses Bio, Pallavi Rajaputra, Gregory Nkepang, Sukyung Woo, Youngjae You
Publikováno v:
ACS Omega, Vol 2, Iss 10, Pp 6349-6360 (2017)
Externí odkaz:
https://doaj.org/article/d1cb7868843a4d84b97a43b8663cefc0
Autor:
Somin Shin, Kyu Yeon Jun, Youngjoo Kwon, Ganesh Bist, Tara Man Kadayat, Aarajana Shrestha, Til Bahadur Thapa Magar, Eung-Seok Lee, Radha Karki, Younghwa Na
Publikováno v:
European Journal of Medicinal Chemistry. 113:228-245
As a continuous effort to develop novel antitumor agents, a new series of forty-five 2-phenol-4-aryl-6-chlorophenyl pyridine compounds were synthesized and evaluated for cytotoxicity against four different human cancer cell lines (DU145, HCT15, T47D,
Publikováno v:
Bioorganic Chemistry. 51:24-30
In order to identify potential calpain and cathepsin inhibitors we prepared 12 dihydroxychalcone analogues and tested their ability to inhibit μ-calpain, m-calpain, cathepsins B and L. In the calpain inhibition test, compound 10 exhibited the most a
Publikováno v:
Future Medicinal Chemistry. 5:2103-2116
The zebrafish (Danio rerio) is a small, tropical, freshwater fish that has emerged as a powerful vertebrate model organism for studying genetics and development. Its small size, transparency, cost–effectiveness, close genome homology to humans comp
Publikováno v:
Bulletin of the Korean Chemical Society. 33:2925-2929
Department of Pharmacology, College of Medicine, Yonsei University, Seoul 120-752, KoreaReceived March 14, 2012, Accepted June 4, 2012Key Words : Hydroxychalcones, Vascular endothelial growth factor (VEGF), Angiogenesis, Chick chorioal-lantoic membra
Autor:
Eunyoung Lee, Won-Jea Cho, Pritam Thapa, Yurngdong Jahng, Eung-Seok Lee, Jae Hun Choi, Uttam Thapa, Younghwa Na, Kyung Hwa Jeon, Youngjoo Kwon, Minho Yun, Radha Karki, Eun Mi Ha
Publikováno v:
European Journal of Medicinal Chemistry. 46:3201-3209
Designed and synthesized were a series of 5 H -chromeno[4,3- b ]pyridines with substitution at 2- and 4-positions with various 5- or 6-membered heteroaromatics as antitumor agents. They were evaluated for topoisomerase I and II inhibitory activities
Autor:
Eunyoung Lee, Hoyoung Choi, Pritam Thapa, Youngjoo Kwon, Younghwa Na, Jung Min Nam, Radha Karki, Eun Mi Ha, Eung-Seok Lee, Byeong Seon Jeong
Publikováno v:
Bulletin of the Korean Chemical Society. 32:303-306
DNA topoisomerases are nuclear enzymes that transiently break one or two strands of DNA, passing a single or double stranded DNA through the break and again resealing the breaks which allow to solve various DNA topological problems ge-nerated during
Publikováno v:
Bulletin of the Korean Chemical Society. 31:1747-1750
Autor:
Radha Karki, Pritam Thapa, Mi Jeong Kang, Tae Cheon Jeong, Jung Min Nam, Hye-Lin Kim, Younghwa Na, Won-Jea Cho, Youngjoo Kwon, Eung-Seok Lee
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:3066-3077
A new series of 2,4-diphenyl-6-aryl pyridines containing hydroxyl group(s) at the ortho, meta, or para position of the phenyl ring were synthesized, and evaluated for topoisomerase I and II inhibitory activity and cytotoxicity against several human c
Autor:
Radha Karki, Hoyoung Choi, Won-Jea Cho, Youngjoo Kwon, Pritam Thapa, Jung Min Nam, Younghwa Na, Byeong-Seon Jeong, Mi-Ja Jung, Jae Hun Choi, Minho Yun, Eung-Seok Lee
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:2245-2254
A series of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives were designed, synthesized, and evaluated for their topoisomerase I and II inhibition and cytotoxic activity against several human cancer cell lines. Compounds 10-19 showed mod