Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Radha Bonala"'
Autor:
Viktoriya S. Sidorenko, Ira Cohen, Kunchok Dorjee, Conceição A. Minetti, David P. Remeta, Junyuan Gao, Irina Potapova, Hong Zhan Wang, Janet Hearing, Wan-Yi Yen, Hwan Keun Kim, Keiji Hashimoto, Masaaki Moriya, Kathleen G. Dickman, Xingyu Yin, Miguel Garcia-Diaz, Rajesh Chennamshetti, Radha Bonala, Francis Johnson, Amanda L. Waldeck, Ramesh Gupta, Chaoping Li, Kenneth J. Breslauer, Arthur P. Grollman, Thomas A. Rosenquist
Publikováno v:
Virus Research, Vol 341, Iss , Pp 199322- (2024)
The emergence of highly infectious pathogens with their potential for triggering global pandemics necessitate the development of effective treatment strategies, including broad-spectrum antiviral therapies to safeguard human health. This study invest
Externí odkaz:
https://doaj.org/article/504d0a1ccfe34d75ad6fc4310a4d74a1
Autor:
Conceição A. Minetti, David P. Remeta, Keiji Hashimoto, Radha Bonala, Rajesh Chennamshetti, Xingyu Yin, Miguel Garcia-Diaz, Arthur P. Grollman, Francis Johnson, Viktoriya S. Sidorenko
Publikováno v:
Life, Vol 12, Iss 6, p 872 (2022)
In an effort to identify functional-energetic correlations leading to the development of efficient anti-SARS-CoV-2 therapeutic agents, we have designed synthetic analogs of aurintricarboxylic acid (ATA), a heterogeneous polymeric mixture of structura
Externí odkaz:
https://doaj.org/article/b45a18937d764fed9f3298c5bbefe18a
Autor:
Keiji Hashimoto, Rajesh Chennamshetti, Radha Bonala, Francis Johnson, Arthur P. Grollman, Viktoriya S. Sidorenko
Publikováno v:
Cancer Research. 82:5480-5480
We have synthesized an analog of aristolochic acid (AA) with potent growth inhibitory activity in various human cancer cell lines and report here on mechanistic studies of this potential therapeutic. AA is a natural product and the main active princi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b24c3bb96a8a52bdae7a48726b041d
https://doi.org/10.1158/1538-7445.am2022-5480
https://doi.org/10.1158/1538-7445.am2022-5480
Autor:
Radha Bonala, Francis Johnson, Arthur P. Grollman, Viktoriya S. Sidorenko, Yoshimitsu Oda, Yoshiharu Okuno, Sivaprasad Attaluri
Publikováno v:
Environmental and Molecular Mutagenesis
Aristolochic acids (AAs) are human nephrotoxins and carcinogens found in concoctions of Aristolochia plants used in traditional medicinal practices worldwide. Genotoxicity of AAs is associated with the formation of active species catalyzed by metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b9b9eaf12957a9df59f9f4c62e3753e
https://doi.org/10.1002/em.22321
https://doi.org/10.1002/em.22321
Autor:
Francis Johnson, Jingshu Guo, Peter W. Villalta, Christopher J. Weight, Radha Bonala, Robert J. Turesky, Thomas A. Rosenquist
Publikováno v:
Chemical Research in Toxicology. 31:1382-1397
Epidemiological studies have linked aromatic amines (AAs) from tobacco smoke and some occupational exposures with bladder cancer risk. Several epidemiological studies have also reported a plausible role for structurally related heterocyclic aromatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db5667940018f8febeca9f7b3dd282b
https://doi.org/10.1021/acs.chemrestox.8b00268
https://doi.org/10.1021/acs.chemrestox.8b00268
Autor:
Medjda Bellamri, Francis Johnson, Radha Bonala, Robert J. Turesky, Linda B. von Weymarn, Lihua Yao
Publikováno v:
Arch Toxicol
Occupational and tobacco exposure to aromatic amines (AAs) including 4-aminobiphenyl (4-ABP) and 2-naphthylamine (2-NA) are associated with bladder cancer (BC) risk. Several epidemiological studies have also reported a possible role for structurally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47250b21694dd3d70171dc474d9b1f8a
https://europepmc.org/articles/PMC6714057/
https://europepmc.org/articles/PMC6714057/
Publikováno v:
DNA Repair. 46:55-60
Translesion DNA synthesis (TLS) operates when replicative polymerases are blocked by DNA lesions. To investigate the mechanism of mammalian TLS, we employed a plasmid bearing a single 7-(deoxyadenosine-N6-yl)-aristolactam I (dA-AL-I) adduct, which is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6005d088769255a239fa8fc0d3bc3960
https://doi.org/10.1016/j.dnarep.2016.07.003
https://doi.org/10.1016/j.dnarep.2016.07.003
Autor:
Arthur P. Grollman, Katherine Ozga, Radha Bonala, Francis Johnson, Keiji Hashimoto, Sivaprasad Attaluri, Irina Zaitseva, Charles R. Iden, Masaaki Moriya, Viktoriya S. Sidorenko
Publikováno v:
Carcinogenesis. 37:647-655
Aristolochic acids (AA) are implicated in the development of chronic renal disease and upper urinary tract carcinoma in humans. Using in vitro approaches, we demonstrated that N-hydroxyaristolactams, metabolites derived from partial nitroreduction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39e8cab26a908fa8ac3dc62a3fd84bd
https://doi.org/10.1093/carcin/bgw045
https://doi.org/10.1093/carcin/bgw045
Autor:
Sergei Pomyalov, Charles R. Iden, Radha Bonala, Francis Johnson, Irina Zaitseva, Gil Shoham, Robert Rieger, Robert J. Turesky, John D. Haley, Viktoriya S. Sidorenko, Arthur P. Grollman, Thomas A. Rosenquist
Publikováno v:
Cancer Research. 79:4660-4660
Aristolochic acid (AA) is a potent human carcinogen and nephrotoxin found in preparations of Aristolochia plants used in Chinese Traditional Medicine. Following biotransformation to form N-sulfonyloxyaristolactam (AL-I-NOSO3), this intermediate under
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::315d0ec2831de32a306e624385f644df
https://doi.org/10.1158/1538-7445.am2019-4660
https://doi.org/10.1158/1538-7445.am2019-4660
Publikováno v:
Chemical Research in Toxicology
Plants from the Aristolochia genus have been recommended for the treatment of a variety of human ailments since the time of Hippocrates. However, many species produce the highly toxic aristolochic acids (AAs), which are both nephrotoxic and carcinoge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::037990edc359743559bd617947b56e9d
http://europepmc.org/articles/PMC4216193
http://europepmc.org/articles/PMC4216193