Výsledky vyhledávání - "Radek Plachy"

A method to identify new molecular markers for assessing minimal residual disease in acute leukemia patients

Autor: Pavlina Havlikova, Pavel Zak, Michal Karas, Annelore Junge, Alzbeta Zavrelova, Radek Cmejla, Lenka Zejskova, Nadezda Kosyakova, Lucie Zemankova, Christian Ramel, Radek Plachy, David Hardekopf, Thomas Liehr, Tereza Jancuskova, Jiri Stika, Tomas Kozak, Sona Pekova

Publikováno v: Leukemia Research. 37:1363-1373

Acute leukemias (AL) comprise a heterogeneous group of hematologic malignancies, and individual patient responses to treatment can be difficult to predict. Monitoring of minimal residual disease (MRD) is thus very important and holds great potential

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9b140a8c3bca2d730bc58e042dd9b99
https://doi.org/10.1016/j.leukres.2013.06.009

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Major molecular response achieved with dasatinib in a CML patient with F317L BCR-ABL kinase domain mutation

Autor: Marie Jarošová, Vladimir Divoky, Marek Stastny, Edgar Faber, Martina Divoka, Karel Indrak, Renata Mojzikova, Sarka Rozmanova, Radek Plachy

Publikováno v: Leukemia Research. 34:e91-e93

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dbfede95d9df94e3fd5b0e047024c5fc
https://doi.org/10.1016/j.leukres.2009.09.009

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Precursor T-Lymphoblastic Lymphoma as a Secondary Malignancy in a Young Patient after Successful Treatment of Acute Promyelocytic Leukemia

Autor: Miroslava Budikova, Jarmila Potomková, Antonin Hlusi, Natalie Klusova, Karel Indrak, Edgar Faber, Radek Plachy, Tomáš Szotkowski, Milena Holzerova, Ladislava Kucerova, Tomas Papajik, Z. Pikalová, Eva Buriánková, Marie Jarošová, Hubácek J, Romana Szotkowska

Publikováno v: Onkologie. 32:513-515

Acute promyelocytic leukemia (APL) is a relatively rare subtype of acute myeloid leukemia. It has become the best curable subtype of acute leukemias in adults due to the inclusion of all-trans-retinoic acid (ATRA) in the treatment. Despite the effica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c48507341f664d2a4c60d2b21f9bbc
https://doi.org/10.1159/000226584

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Array-based karyotyping in chronic lymphocytic leukemia (CLL) detects new unbalanced abnormalities that escape conventional cytogenetics and CLL FISH panel

Autor: Z. Pikalová, Radek Plachy, Marie Jarošová, Jana Balcarkova, Karel Indrak, Vít Procházka, Tomas Papajik, Milena Holzerova, Helena Urbankova, Martina Divoka

Publikováno v: Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia. 158(1)

Aims: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia with a very heterogeneous course. Progress in molecular genetic characterization of CLL has confirmed the prognostic role of unbalanced chromosomal abnormalities currently def

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f4d46fc9012331fe993d990ad71bd2d
https://pubmed.ncbi.nlm.nih.gov/23073527

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Gain of chromosome 2p in chronic lymphocytic leukemia: significant heterogeneity and a new recurrent dicentric rearrangement

Autor: Tomas Papajik, Radek Plachy, Helena Urbankova, Marie Jarošová, Jana Balcarkova, Z. Pikalová, Vladimir Divoky, Milena Holzerova, Karel Indrak

Publikováno v: Leukemialymphoma. 51(2)

Array-based comparative genomic hybridization (arrayCGH) studies in chronic lymphocytic leukemia (CLL) have revealed novel recurrent chromosomal imbalances, such as a gain of chromosome 2p. However, a detailed cytogenetic analysis of the 2p gain regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68b9426a0a2d49d3271a42f18cad19db
https://pubmed.ncbi.nlm.nih.gov/20109070

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Identification of Novel Molecular Markers for the Follow-up of Minimal Residual Disease in Hematooncological Disorders

Autor: Tomas Kozak, Marie Jarošová, Lukas Smolej, Radek Cmejla, Pavel Zak, Michal Karas, David Hardekopf, Lenka Zejskova, Radek Plachy, Lucie Krutilkova, Tereza Jancuskova, Jan Vydra, Vladimir Koza, Sona Pekova, Alzbeta Zavrelova

Publikováno v: Blood. 118:4905-4905

Abstract 4905 Modern molecular diagnostic techniques allow the detection of minimal residual disease (MRD) in hematological malignancies with high sensitivity, allowing patient-specific assays of MRD levels over the course of treatment. One challenge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::75d3be44466d572084ee03ae5ef68b05
https://doi.org/10.1182/blood.v118.21.4905.4905

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Harmonized Testing for BCR-ABL Kinase Domain Mutations In CML: Results of a Survey and First Control Round within 28 National Reference Laboratories In Europe

Publikováno v: Blood. 116:894-894

Abstract 894 Various techniques have been employed to detect BCR-ABL kinase domain mutations in patients with chronic myeloid leukemia (CML) resistant to imatinib or second generation tyrosine kinase inhibitors. This variation may at least partially

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::645e55a089068ff58b9a919109ad4fe7
https://doi.org/10.1182/blood.v116.21.894.894

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Five-Color Multiplex Real-Time PCR Technology to Detect Over 75 Recurrent Chromosomal Abnormalities in Acute Myeloid Leukemia; Benefits for Minimal Residual Disease Detection

Autor: Lukas Smolej, Vladimir Koza, Radek Plachy, Lenka Zejskova, Sona Pekova, Lucie Krutilkova, Jan Vydra, Tereza Jancuskova, Radek Cmejla, Pavel Zak, David Hardekopf, Michal Karas

Publikováno v: ResearcherID

Abstract 2526 Many studies on childhood and adult leukemias have demonstrated that thorough molecular analysis at the time of diagnosis and minimal residual disease (MRD) follow-up are significantly related to the prognosis, and overall- and event-fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca47cffcefbfa27f483bb43bc2157b7b
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000299597103392&KeyUID=WOS:000299597103392

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Molecular characterization of the rare translocation t(3;10)(q26;q21) in an acute myeloid leukemia patient

Autor: Lucie Zemankova, Jiri Stika, Nadezda Kosyakova, Lenka Zejskova, Sona Pekova, Tereza Jancuskova, Inka Praulich, Achim Rothe, Moneeb A.K. Othman, Radek Plachy, David Hardekopf, Karl-Anton Kreuzer

Publikováno v: Molecular Cytogenetics

Background In acute myeloid leukemia (AML), the MDS1 and EVI1 complex locus - MECOM, also known as the ecotropic virus integration site 1 - EVI1, located in band 3q26, can be rearranged with a variety of partner chromosomes and partner genes. Here we

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