Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Radek Lakomy"'
Autor:
Peter Solár, Zdenek Mackerle, Michal Hendrych, Petr Pospisil, Radek Lakomy, Hana Valekova, Marketa Hermanova, Radim Jancalek
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
High-grade gliomas are primary brain tumors with poor prognosis, despite surgical treatment followed by radiotherapy and concomitant chemotherapy. We present two cases of long-term survival in patients treated for high-grade glioma and concomitant pr
Externí odkaz:
https://doaj.org/article/018621220dc84f3ea078271f550e5f74
Autor:
Michal Hendrych, Peter Solar, Marketa Hermanova, Ondrej Slaby, Hana Valekova, Marek Vecera, Alena Kopkova, Zdenek Mackerle, Tomas Kazda, Petr Pospisil, Radek Lakomy, Jan Chrastina, Jiri Sana, Radim Jancalek
Publikováno v:
Diagnostics, Vol 13, Iss 2, p 181 (2023)
Glioblastoma (GBM) is regarded as an aggressive brain tumor that rarely develops extracranial metastases. Despite well-investigated molecular alterations in GBM, there is a limited understanding of these associated with the metastatic potential. We h
Externí odkaz:
https://doaj.org/article/2d92de1fcac74c1f93785f454dc71447
Autor:
Michael Bartos, Frantisek Siegl, Alena Kopkova, Lenka Radova, Jan Oppelt, Marek Vecera, Tomas Kazda, Radim Jancalek, Michal Hendrych, Marketa Hermanova, Petra Kasparova, Zuzana Pleskacova, Vaclav Vybihal, Pavel Fadrus, Martin Smrcka, Radek Lakomy, Radim Lipina, Tomas Cesak, Ondrej Slaby, Jiri Sana
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Glioblastoma (GBM) is the most frequently occurring primary malignant brain tumor of astrocytic origin. To change poor prognosis, it is necessary to deeply understand the molecular mechanisms of gliomagenesis and identify new potential biomarkers and
Externí odkaz:
https://doaj.org/article/94d22527aabb4477a1afa411c71b7e62
Autor:
Radek Lakomy, Tomas Kazda, Iveta Selingerova, Alexandr Poprach, Petr Pospisil, Renata Belanova, Pavel Fadrus, Vaclav Vybihal, Martin Smrcka, Radim Jancalek, Ludmila Hynkova, Katarina Muckova, Michal Hendrych, Jiri Sana, Ondrej Slaby, Pavel Slampa
Publikováno v:
Frontiers in Oncology, Vol 10 (2020)
The aim of this retrospective study is to provide real-world evidence in glioblastoma treatment and to compare overall survival after Stupp's regimen treatment today and a decade ago. A current consecutive cohort of histologically confirmed glioblast
Externí odkaz:
https://doaj.org/article/1d0758fd945243c3bb797cdae45d2383
Autor:
Jiri Sana, Petr Busek, Pavel Fadrus, Andrej Besse, Lenka Radova, Marek Vecera, Stefan Reguli, Lucie Stollinova Sromova, Marek Hilser, Radim Lipina, Radek Lakomy, Leos Kren, Martin Smrcka, Aleksi Sedo, Ondrej Slaby
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Glioblastoma stem-like cells (GSCs) are critical for the aggressiveness and progression of glioblastoma (GBM) and contribute to its resistance to adjuvant treatment. MicroRNAs (miRNAs) are small, non-coding RNAs controlling gene expression a
Externí odkaz:
https://doaj.org/article/45af015b41e7425cbe979cb802a41555
Autor:
Tomas Kazda, Miroslav Vrzal, Tomas Prochazka, Petr Dvoracek, Petr Burkon, Petr Pospisil, Adam Dziacky, Tomas Nikl, Radim Jancalek, Pavel Slampa, Radek Lakomy
Publikováno v:
Biomedical Papers, Vol 161, Iss 4, Pp 397-402 (2017)
Aims: Unilateral sparing of the dominant (left) hippocampus during whole brain radiotherapy (WBRT) could mitigate cognitive decline, especially verbal memory, similar to the widely investigated bilateral hippocampus avoidance (HA-WBRT). The aim of th
Externí odkaz:
https://doaj.org/article/f3c3d5c735bb43a18b2909ed0e1b6c58
Autor:
Radek Lakomy, Alexandr Poprach, Zbynek Bortlicek, Bohuslav Melichar, Renata Chloupkova, Rostislav Vyzula, Milada Zemanova, Katerina Kopeckova, Marek Svoboda, Ondrej Slaby, Igor Kiss, Hana Studentova, Jaroslav Juracek, Ondrej Fiala, Jindrich Kopecky, Jindrich Finek, Ladislav Dusek, Karel Hejduk, Tomas Buchler
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-8 (2017)
Abstract Background It is well known that patient characteristics and survival outcomes in randomized trials may not necessarily be similar to those in real-life clinical practice. The aim of the present study was to analyse second line treatment str
Externí odkaz:
https://doaj.org/article/0a8555e1bc4d4de2ae22bfbdd71ada34
Autor:
Tomas Kazda, Martin Bulik, Petr Pospisil, Radek Lakomy, Martin Smrcka, Pavel Slampa, Radim Jancalek
Publikováno v:
NeuroImage: Clinical, Vol 11, Iss C, Pp 316-321 (2016)
The accurate identification of glioblastoma progression remains an unmet clinical need. The aim of this prospective single-institutional study is to determine and validate thresholds for the main metabolite concentrations obtained by MR spectroscopy
Externí odkaz:
https://doaj.org/article/0cfaa1ad0bb44cecaf8c2d7eea3dfde2
Autor:
Radek Lakomy, Tomas Kazda, Iveta Selingerova, Alexandr Poprach, Petr Pospisil, Renata Belanova, Pavel Fadrus, Martin Smrcka, Vaclav Vybihal, Radim Jancalek, Igor Kiss, Katarina Muckova, Michal Hendrych, Andrea Knight, Jiri Sana, Pavel Slampa, Ondrej Slaby
Publikováno v:
Diagnostics, Vol 10, Iss 9, p 676 (2020)
Background: The aim of this retrospective study is to assess the incidence, localization, and potential predictors of rapid early progression (REP) prior to initiation of radiotherapy in newly diagnosed glioblastoma patients and to compare survival o
Externí odkaz:
https://doaj.org/article/a8f790cb110e456994410d2502f399bc
Autor:
Pavel Fadrus, Vaclav Vybihal, Vilem Juran, Ivana Roskova, Andrea Sprlakova-Pukova, Tereza Koprivova, Milos Kerkovsky, Radek Lakomy, Tomas Kazda, Ludmila Hynkova, Renata Belanova, Marek Vecera, Marketa Hermanova, Radim Jancalek, Jiri Sana, Ondrej Slaby, Pavel Slampa, Martin Smrcka
Publikováno v:
Neuro-Oncology. 24:vii252-vii253
INTRODUCTION Modern comprehensive local treatment of BM provides the possibility of adequate local control while maintaining a satisfactory quality of life. METHODS Patients after metastasectomy and postoperative radiotherapy treated between 2007-202