Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Radek Jaksa"'
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Western blot analysis showing protein expression profile of key regulators of apoptosis in 18 DLBCL cell lines (12 germinal center B-cell-like (GCB) and 6 activated B-cell-like (ABC) DLBCL cell lines). *UPF4D cell line (GCB origin) was derived in our
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c173972cf2e268702b74b82a1e49d1e3
https://doi.org/10.1158/1078-0432.22457130
https://doi.org/10.1158/1078-0432.22457130
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Purpose: To investigate the roles of BCL2, MCL1, and BCL-XL in the survival of diffuse large B-cell lymphoma (DLBCL).Experimental designs: Immunohistochemical analysis of 105 primary DLBCL samples, and Western blot analysis of 18 DLBCL cell lines for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52f7657670078fc56e9d1f3aa2eb5276
https://doi.org/10.1158/1078-0432.c.6523509.v1
https://doi.org/10.1158/1078-0432.c.6523509.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Shown are examples of different levels of semi-quantitative protein expression (0-3).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d072966c6995f80fa38e44a6170501a
https://doi.org/10.1158/1078-0432.22457133
https://doi.org/10.1158/1078-0432.22457133
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
To investigate whether the expression level of BCL2 proteins detected by western blot is comparable with the expression level assessed by IHC analysis, we analyzed protein expression (by IHC) of BCL2, MCL1 and BCL-XL from subcutaneous lymphoma xenogr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63969706514c34ab22db984109d7a24f
https://doi.org/10.1158/1078-0432.22457115.v1
https://doi.org/10.1158/1078-0432.22457115.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
(A) Comparison of the extent of apopotosis induced by HHT (after 24hrs exposure) in HHT-resistant (HHT-R) clones compared to the original cell lines (CTRL). (B) Western blot analysis demonstrates upregulation of BCL-XL protein in HHT-R clones compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::883706f3111a5507d671c92a8ec2bf45
https://doi.org/10.1158/1078-0432.22457118
https://doi.org/10.1158/1078-0432.22457118
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
The graphs show the extent of apoptosis of DLBCL cell lines induced by different concentrations of HHT, ABT-199 and ABT-737 after 24hrs exposure to particular agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a5e50a0a51e72b6007cddc684aa7ff2
https://doi.org/10.1158/1078-0432.22457124.v1
https://doi.org/10.1158/1078-0432.22457124.v1
Autor:
Pavel Klener, Marek Trneny, Robert Pytlik, Roman Kodet, Mahmudul Alam, Bokang Calvin Lenyeletse Maswabi, Jan Molinsky, Lucie Lateckova, Petra Vockova, Karel Helman, Radek Jaksa, Dana Vejmelkova, Dana Prukova, Jan Soukup, Simona Benesova, Jan Svadlenka, Jan Brazina, Ladislav Andera, Magdalena Klanova
Cell of origin (COO), BCL2 expression status and IC100 for ABT-199 (µM) and HHT (nM) are shown.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1397d4117a0aff828cfc6dc72b61ae48
https://doi.org/10.1158/1078-0432.22457112.v1
https://doi.org/10.1158/1078-0432.22457112.v1
Autor:
Bui Quang Hiep, Michaela Bártů, Věra Franková, Ladislav Hadravský, Kateřina Jirsová, Jana Kopejsková, Jakub Řezáč, Pavel Dundr, Otakar Čapoun, Eva Krkavcová, Lenka Kleissnerová, Nikola Hájková, Kristýna Němejcová, Romana Michálková, Radek Jaksa, Jan Hojný, Ivana Stružinská
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports
Scientific Reports
Hepatocyte nuclear factor 1 beta (HNF1B) is a tissue specific transcription factor, which seems to play an important role in the carcinogenesis of several tumors. In our study we focused on analyzing HNF1B in prostate carcinoma (PC) and adenomyomatou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfd675b7db1fdf520c61f6f61645b3ad
http://link.springer.com/article/10.1038/s41598-020-71427-7
http://link.springer.com/article/10.1038/s41598-020-71427-7
Autor:
Kristyna Kolouchova, Zulfiya Cernochova, Ondrej Groborz, Vit Herynek, Filip Koucky, Radek Jaksa, Jiri Benes, Miroslav Slouf, Martin Hruby
Publikováno v:
European Polymer Journal. 175:111381
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9a236e47b7e19e5c3ce025040c78721d
https://doi.org/10.1016/j.eurpolymj.2022.111381
https://doi.org/10.1016/j.eurpolymj.2022.111381
Autor:
Michaela Bártů, Ivana Tichá, Ondřej Kodet, Radek Jaksa, Pavel Dundr, Miroslav Důra, Kristýna Němejcová, Romana Michálková
Publikováno v:
Pigment Cell & Melanoma Research. 32:412-423
The objective of our study was to compare the five different scoring methods of tumor-infiltrating lymphocytes (TILs) assessment in a group of 213 cases of superficial spreading and nodular melanoma. The scoring methods include (a) Clark scoring; (b)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ad4d06c8a498c4d8c1bea2a06a7c9cb
https://doi.org/10.1111/pcmr.12757
https://doi.org/10.1111/pcmr.12757