Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Radek Indra"'
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112391- (2022)
Lenvatinib, a small molecule tyrosine kinase inhibitor (TKI), exhibits good inhibitory effect in several types of carcinomas. Specifically, it is the most effective TKI used for treatment of thyroid cancer. To extend pharmacokinetics data on this ant
Externí odkaz:
https://doaj.org/article/2f244a7545cb4a5faf7f44487ac55988
Autor:
Helena Dračínská, Radek Indra, Sandra Jelínková, Věra Černá, Volker Manfred Arlt, Marie Stiborová
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 15, p 8062 (2021)
The environmental pollutant benzo[a]pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase. The azo dye Sudan I is a potent inducer
Externí odkaz:
https://doaj.org/article/38bc17c9972149999749e157fffd447e
Autor:
Kateřina Jáklová, Tereza Feglarová, Simona Rex, Zbyněk Heger, Tomáš Eckschlager, Jan Hraběta, Petr Hodek, Matúš Kolárik, Radek Indra
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 8, p 4250 (2021)
A tyrosine kinase inhibitor, vandetanib (Van), is an anticancer drug affecting the signaling of VEGFR, EGFR and RET protooncogenes. Van is primarily used for the treatment of advanced or metastatic medullary thyroid cancer; however, its usage is sign
Externí odkaz:
https://doaj.org/article/396c504b67bd4c449cfa0abb83b41c12
Publikováno v:
Biomedicines, Vol 8, Iss 12, p 547 (2020)
Herein, the in vitro metabolism of tyrosine kinase inhibitor cabozantinib, the drug used for the treatment of metastatic medullary thyroid cancer and advanced renal cell carcinoma, was studied using hepatic microsomal samples of different human donor
Externí odkaz:
https://doaj.org/article/a49d55891bc547c19c2ebc52e3eb3fd4
Autor:
Radek Indra, Petr Pompach, Václav Martínek, Paulína Takácsová, Katarína Vavrová, Zbyněk Heger, Vojtěch Adam, Tomáš Eckschlager, Kateřina Kopečková, Volker Manfred Arlt, Marie Stiborová
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3392 (2019)
The metabolism of vandetanib, a tyrosine kinase inhibitor used for treatment of symptomatic/progressive medullary thyroid cancer, was studied using human hepatic microsomes, recombinant cytochromes P450 (CYPs) and flavin-containing monooxygenases (FM
Externí odkaz:
https://doaj.org/article/83936630d3544288aeea09a012d49661
Autor:
Helena, Dračínská, Radek, Indra, Sandra, Jelínková, Věra, Černá, Volker Manfred, Arlt, Marie, Stiborová
Publikováno v:
International Journal of Molecular Sciences
The environmental pollutant benzo[a]pyrene (BaP) is a human carcinogen that reacts with DNA after metabolic activation catalysed by cytochromes P450 (CYP) 1A1 and 1B1 together with microsomal epoxide hydrolase. The azo dye Sudan I is a potent inducer
Autor:
Radek Indra, Hector C. Keun, David H. Phillips, Marie-Hélène Antoine, Mateja Sborchia, Joëlle Nortier, Lucie Bienfait, Marie Stiborová, Volker M. Arlt, Gabriel N. Valbuena, Eric De Prez
Publikováno v:
Archives of toxicology, 93 (11
Archives of Toxicology
Archives of Toxicology
Exposure to aristolochic acid (AA) is associated with human nephropathy and urothelial cancer. The tumour suppressor TP53 is a critical gene in carcinogenesis and frequently mutated in AA-induced urothelial tumours. We investigated the impact of p53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d9dd56be7a6f46afa90af03ea836a20
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/296663
http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/296663
Autor:
Radek Indra, David H. Phillips, Volker M. Arlt, Iveta Mrizova, Colin J. Henderson, Michaela Moserová, Klaus Kopka, Lindsay Reed, Heinz H. Schmeiser, František Bárta, Marie Stiborová, C. Roland Wolf
Publikováno v:
Archives of Toxicology
Reed, L, Mrizova, I, Barta, F, Indra, R, Moserova, M, Kopka, K, Schmeiser, H H, Wolf, C R, Henderson, C J, Stiborova, M, Phillips, D H & Arlt, V M 2018, ' Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation : studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice ', Archives of Toxicology, vol. 92, no. 4, pp. 1625-1638 . https://doi.org/10.1007/s00204-018-2162-7
Reed, L, Mrizova, I, Barta, F, Indra, R, Moserova, M, Kopka, K, Schmeiser, H H, Wolf, C R, Henderson, C J, Stiborova, M, Phillips, D H & Arlt, V M 2018, ' Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation : studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice ', Archives of Toxicology, vol. 92, no. 4, pp. 1625-1638 . https://doi.org/10.1007/s00204-018-2162-7
Benzo[a]pyrene (BaP) is an environmental pollutant that, based on evidence largely from in vitro studies, exerts its genotoxic effects after metabolic activation by cytochrome P450s. In the present study, Hepatic Reductase Null (HRN) and Hepatic Cyto
Autor:
Marketa Martinkova, Marek Wilhelm, Alžběta Lengálová, Volker M. Arlt, Zbyněk Heger, Simona Dostalova, Heinz H. Schmeiser, Tomas Eckschlager, Tereza Cerna, Radek Indra, Marie Stiborová, Vojtěch Adam, Jan Hraběta
Publikováno v:
Indra, R, Černá, T, Heger, Z, Hraběta, J, Wilhelm, M, Dostálová, S, Lengálová, A, Martínková, M, Adam, V, Eckschlager, T, Schmeiser, H H, Arlt, V M & Stiborová, M 2019, ' Ellipticine-loaded apoferritin nanocarrier retains DNA adduct-based cytochrome P450-facilitated toxicity in neuroblastoma cells ', Toxicology, vol. 419, pp. 40-54 . https://doi.org/10.1016/j.tox.2019.03.009
Although ellipticine (Elli) is an efficient anticancer agent, it exerts several adverse effects. One approach to decrease the adverse effects of drugs is their encapsulation inside a suitable nanocarrier, allowing targeted delivery to tumour tissue w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410e55f7c653c5e908a9253ffea492f1
https://kclpure.kcl.ac.uk/ws/files/107877103/Indra_etal_Toxicology_2019.pdf
https://kclpure.kcl.ac.uk/ws/files/107877103/Indra_etal_Toxicology_2019.pdf
Autor:
Lindsay, Reed, Radek, Indra, Iveta, Mrizova, Michaela, Moserova, Heinz H, Schmeiser, C Roland, Wolf, Colin J, Henderson, Marie, Stiborova, David H, Phillips, Volker M, Arlt
Publikováno v:
Toxicology and Applied Pharmacology
The anticancer drug ellipticine exerts its genotoxic effects after metabolic activation by cytochrome P450 (CYP) enzymes. The present study has examined the role of cytochrome P450 oxidoreductase (POR) and cytochrome b5 (Cyb5), electron donors to P45