Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Radek Fedr"'
Autor:
Jiřina Procházková, Radek Fedr, Barbora Hradilová, Barbora Kvokačková, Josef Slavík, Ondrej Kováč, Miroslav Machala, Pavel Fabian, Jiří Navrátil, Simona Kráčalíková, Monika Levková, Petra Ovesná, Jan Bouchal, Karel Souček
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 9, Pp 100609- (2024)
Glycosylated sphingolipids (GSLs) are a diverse group of cellular lipids typically reported as being rare in normal mammary tissue. In breast cancer (BCa), GSLs have emerged as noteworthy markers associated with breast cancer stem cells, mediators of
Externí odkaz:
https://doaj.org/article/8695b11de69142bb8fd36374fbb5206d
Autor:
Markéta Pícková, Zuzana Kahounová, Tomasz Radaszkiewicz, Jiřina Procházková, Radek Fedr, Michaela Nosková, Katarzyna Anna Radaszkiewicz, Petra Ovesná, Vítězslav Bryja, Karel Souček
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Metastatic melanoma, a highly lethal form of skin cancer, presents significant clinical challenges due to limited therapeutic options and high metastatic capacity. Recent studies have demonstrated that cancer dissemination can occur earlier,
Externí odkaz:
https://doaj.org/article/e0bd277f452f4f1b9cbd5f9d9804c57b
Autor:
Barbora Kvokačková, Radek Fedr, Daniela Kužílková, Jan Stuchlý, Adéla Vávrová, Jiří Navrátil, Pavel Fabian, Róbert Ondruššek, Petra Ovesná, Ján Remšík, Jan Bouchal, Tomáš Kalina, Karel Souček
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 1024-1040 (2023)
Triple‐negative breast cancer (TNBC) is an aggressive and complex subtype of breast cancer that lacks targeted therapy. TNBC manifests characteristic, extensive intratumoral heterogeneity that promotes disease progression and influences drug respon
Externí odkaz:
https://doaj.org/article/902a68d47202494e8964ad7e6e6c97dc
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract The distribution of fluorescence signals measured with flow cytometry can be influenced by several factors, including qualitative and quantitative properties of the used fluorochromes, optical properties of the detection system, as well as t
Externí odkaz:
https://doaj.org/article/b028f155bd954024864a1e10325a277c
Autor:
Stanislav Drápela, Prashant Khirsariya, Wytske M. vanWeerden, Radek Fedr, Tereza Suchánková, Diana Búzová, Jan Červený, Aleš Hampl, Martin Puhr, William R. Watson, Zoran Culig, Lumír Krejčí, Kamil Paruch, Karel Souček
Publikováno v:
Molecular Oncology, Vol 14, Iss 10, Pp 2487-2503 (2020)
As treatment options for patients with incurable metastatic castration‐resistant prostate cancer (mCRPC) are considerably limited, novel effective therapeutic options are needed. Checkpoint kinase 1 (CHK1) is a highly conserved protein kinase impli
Externí odkaz:
https://doaj.org/article/245939cd91484669b8fffb8ca46e74cb
Autor:
Marta Elsheimer-Matulova, Ondrej Polansky, Zuzana Seidlerova, Karolina Varmuzova, Hana Stepanova, Radek Fedr, Ivan Rychlik
Publikováno v:
Veterinary Research, Vol 51, Iss 1, Pp 1-8 (2020)
Abstract In attempt to identify genes that are induced in chickens by Salmonella Enteritidis we identified a new highly inducible gene, interleukin 4 induced 1 gene (IL4I1). IL4I1 reached its peak expression (458× induction) in the cecum of newly ha
Externí odkaz:
https://doaj.org/article/7c2f9f8a5ac8457697d5ec50160b87d7
Autor:
Martina Karasová, Jiřina Procházková, Zuzana Tylichová, Radek Fedr, Miroslav Ciganek, Miroslav Machala, Zdeněk Dvořák, Barbora Vyhlídalová, Iveta Zůvalová, Jiří Ehrmann, Jan Bouchal, Zdeněk Andrysík, Jan Vondráček
Publikováno v:
Cancers, Vol 14, Iss 17, p 4245 (2022)
The aryl hydrocarbon receptor (AhR) plays a wide range of physiological roles in cellular processes such as proliferation, migration or control of immune responses. Several studies have also indicated that AhR might contribute to the regulation of en
Externí odkaz:
https://doaj.org/article/56d11172df114aa5a2b57c8da8e88402
Autor:
Zuzana Kahounová, Eva Slabáková, Lucia Binó, Ján Remšík, Radek Fedr, Jan Bouchal, Daniela Kurfűrstová, Radek Vrtěl, Vladimír Študent, Lucie Jurečková, Volodymyr Porokh, Aleš Hampl, Karel Souček
Publikováno v:
Stem Cell Research, Vol 33, Iss , Pp 255-259 (2018)
A human induced pluripotent stem cell line was generated from cancer-associated fibroblasts of a 68-years old patient with diagnosed prostate adenocarcinoma (PCa). The fibroblast cell line was reprogrammed with Epi5™ Episomal iPSC Reprogramming Kit
Externí odkaz:
https://doaj.org/article/ff7f398ed78e4e059a1dbe047213f717
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
FGF signaling plays an essential role in lung development, homeostasis, and regeneration. We employed mouse 3D cell culture models and imaging to study ex vivo the role of FGF ligands and the interplay of FGF signaling with epithelial growth factor (
Externí odkaz:
https://doaj.org/article/2f98a68d22ff49a7b1d64fa170e47e5b
Autor:
Zuzana Kahounová, Ján Remšík, Radek Fedr, Jan Bouchal, Alena Mičková, Eva Slabáková, Lucia Binó, Aleš Hampl, Karel Souček
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101844- (2020)
Deciphering the properties of adult stem cells is crucial for understanding of their role in healthy tissue and in cancer progression as well. Both stem cells and cancer stem cells have shown association with epithelial-to-mesenchymal transition (EMT
Externí odkaz:
https://doaj.org/article/86a34fde54fb4d0281b36574a5423019