Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Radek, Polanski"'
Autor:
Jason G. Kettle, Sharan K. Bagal, Sue Bickerton, Michael S. Bodnarchuk, Scott Boyd, Jason Breed, Rodrigo J. Carbajo, Doyle J. Cassar, Atanu Chakraborty, Sabina Cosulich, Iain Cumming, Michael Davies, Nichola L. Davies, Andrew Eatherton, Laura Evans, Lyman Feron, Shaun Fillery, Emma S. Gleave, Frederick W. Goldberg, Lyndsey Hanson, Stephanie Harlfinger, Martin Howard, Rachel Howells, Anne Jackson, Paul Kemmitt, Gillian Lamont, Scott Lamont, Hilary J. Lewis, Libin Liu, Michael J. Niedbala, Christopher Phillips, Radek Polanski, Piotr Raubo, Graeme Robb, David M. Robinson, Sarah Ross, Matthew G. Sanders, Michael Tonge, Rebecca Whiteley, Stephen Wilkinson, Junsheng Yang, Wenman Zhang
Publikováno v:
Journal of Medicinal Chemistry. 65:6940-6952
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplemtary figures 1-9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0254ee54451d26a1e2706aaccbaf44f8
https://doi.org/10.1158/1078-0432.22463216.v1
https://doi.org/10.1158/1078-0432.22463216.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplementary Table results
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e38fe420d400c7fb1812b394c0d16e8
https://doi.org/10.1158/1078-0432.22463210.v1
https://doi.org/10.1158/1078-0432.22463210.v1
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplementary Table Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b69d7b0c7f1ef99c6856bb17319c451d
https://doi.org/10.1158/1078-0432.22463213
https://doi.org/10.1158/1078-0432.22463213
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Purpose: PTEN-null tumors become dependent on the PI3Kβ isoform and can be targeted by molecules such as the selective PI3Kβ inhibitor AZD8186. However, beyond the modulation of the canonical PI3K pathway, the consequences of inhibiting PI3Kβ are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e357256d933e04d7180466b15cfa0a8
https://doi.org/10.1158/1078-0432.c.6525344
https://doi.org/10.1158/1078-0432.c.6525344
Autor:
Simon T. Barry, Francisco Cruzalegui, Susan E. Critchlow, Marie Cumberbatch, Anna Staniszewska, James Pilling, Alvaro Avivar-Valderas, Rebecca Ellston, Radek Polanski, James Bradford, Robert McEwen, Carol Lenaghan, Filippos Michopoulos, Antonio G. Trinidad, Urs Hancox, Oona Delpuech, Urszula M. Polanska, James T. Lynch
Supplemental data figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15e8dfb1623fe8e4b2a1b39597fe34ae
https://doi.org/10.1158/1078-0432.22463222
https://doi.org/10.1158/1078-0432.22463222
Autor:
Jason G, Kettle, Sharan K, Bagal, Sue, Bickerton, Michael S, Bodnarchuk, Scott, Boyd, Jason, Breed, Rodrigo J, Carbajo, Doyle J, Cassar, Atanu, Chakraborty, Sabina, Cosulich, Iain, Cumming, Michael, Davies, Nichola L, Davies, Andrew, Eatherton, Laura, Evans, Lyman, Feron, Shaun, Fillery, Emma S, Gleave, Frederick W, Goldberg, Lyndsey, Hanson, Stephanie, Harlfinger, Martin, Howard, Rachel, Howells, Anne, Jackson, Paul, Kemmitt, Gillian, Lamont, Scott, Lamont, Hilary J, Lewis, Libin, Liu, Michael J, Niedbala, Christopher, Phillips, Radek, Polanski, Piotr, Raubo, Graeme, Robb, David M, Robinson, Sarah, Ross, Matthew G, Sanders, Michael, Tonge, Rebecca, Whiteley, Stephen, Wilkinson, Junsheng, Yang, Wenman, Zhang
Publikováno v:
Journal of medicinal chemistry. 65(9)
KRAS is an archetypal high-value intractable oncology drug target. The glycine to cysteine mutation at codon 12 represents an Achilles heel that has now rendered this important GTPase druggable. Herein, we report our structure-based drug design appro
Autor:
Jason G, Kettle, Sharan K, Bagal, Sue, Bickerton, Michael S, Bodnarchuk, Jason, Breed, Rodrigo J, Carbajo, Doyle J, Cassar, Atanu, Chakraborty, Sabina, Cosulich, Iain, Cumming, Michael, Davies, Andrew, Eatherton, Laura, Evans, Lyman, Feron, Shaun, Fillery, Emma S, Gleave, Frederick W, Goldberg, Stephanie, Harlfinger, Lyndsey, Hanson, Martin, Howard, Rachel, Howells, Anne, Jackson, Paul, Kemmitt, Jennifer K, Kingston, Scott, Lamont, Hilary J, Lewis, Songlei, Li, Libin, Liu, Derek, Ogg, Christopher, Phillips, Radek, Polanski, Graeme, Robb, David, Robinson, Sarah, Ross, James M, Smith, Michael, Tonge, Rebecca, Whiteley, Junsheng, Yang, Longfei, Zhang, Xiliang, Zhao
Publikováno v:
Journal of medicinal chemistry. 63(9)
Attempts to directly drug the important oncogene KRAS have met with limited success despite numerous efforts across industry and academia. The KRAS
Autor:
James T. Lynch, Alvaro Avivar-Valderas, Anna Staniszewska, Carol Lenaghan, Robert McEwen, Simon T. Barry, Marie Cumberbatch, James Pilling, Urs Hancox, Oona Delpuech, Filippos Michopoulos, Radek Polanski, James R. Bradford, Rebecca Ellston, Antonio García Trinidad, Francisco Cruzalegui, Susan E. Critchlow, Urszula M. Polanska
Publikováno v:
Clinical Cancer Research. 23:7584-7595
Purpose: PTEN-null tumors become dependent on the PI3Kβ isoform and can be targeted by molecules such as the selective PI3Kβ inhibitor AZD8186. However, beyond the modulation of the canonical PI3K pathway, the consequences of inhibiting PI3Kβ are