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Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy

Autor: Schroeder, MA, Atherton, HJ, Ball, DR, Cole, MA, Heather, LC, Griffin, JL, Clarke, K, Radda, GK, Tyler, DJ

The Krebs cycle plays a fundamental role in cardiac energy production and is often implicated in the energetic imbalance characteristic of heart disease. In this study, we measured Krebs cycle flux in real time in perfused rat hearts using hyperpolar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::e72a8c963c23553590163f54cb3afea2
https://ora.ox.ac.uk/objects/uuid:fc6098eb-94ac-4064-91df-fb86b75be282

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Investigating Metabolic Flux in the Hyperthyroid Heart using Hyperpolarised Magnetic Resonance

Autor: Atherton, HJ, Schroeder, MA, Heather, LC, Clarke, K, Radda, GK, Tyler, DJ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::841841d8877ac106f1fddfa247525ce5
https://ora.ox.ac.uk/objects/uuid:3a07bfaf-478c-44b0-8204-d628e73deff5

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Decreased GLUT4 translocation underlies the cardiomyopathy associated with Duchenne muscular dystrophy

Autor: Sang, AE, Bia, BL, Wilding, JR, Radda, GK, Davies, KE, Clarke, K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::27574ee62c82cdd661575f8ce18f6e30
https://ora.ox.ac.uk/objects/uuid:911b2cf5-5a0a-4726-a559-7148eb28a633

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Impaired insulin signal transduction and glucose transport in the type 2 diabetic heart

Autor: Desrois, M, Sidell, RJ, King, LM, Gauguier, D, Radda, GK, Clarke, K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::3234dade2654d9e2e94d91e308445dc8
https://ora.ox.ac.uk/objects/uuid:5ecb7c88-aa93-4dba-8752-3a3ab3d19f72

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Determining the in vivo regulation of cardiac pyruvate dehydrogenase based on label flux from hyperpolarised [1-13C]pyruvate

Autor: Schroeder, MA, Atherton, HJ, Heather, LC, Griffin, JL, Clarke, K, Radda, GK, Tyler, DJ

Pyruvate dehydrogenase (PDH) is a key regulator of cardiac substrate selection and is regulated by both pyruvate dehydrogenase kinase (PDK)-mediated phosphorylation and feedback inhibition. The extent to which chronic upregulation of PDK protein leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::b75f9458ec0e88914560afb614e1764b
https://ora.ox.ac.uk/objects/uuid:3943e17f-5cbe-476c-a450-6a1cb93f07e6

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