A novel splice variant of Elp3/Kat9 regulates mitochondrial tRNA modification and function

Autor: Rachid Boutoual, Hyunsun Jo, Indra Heckenbach, Ritesh Tiwari, Herbert Kasler, Chad A. Lerner, Samah Shah, Birgit Schilling, Vincenzo Calvanese, Matthew J. Rardin, Morten Scheibye-Knudsen, Eric Verdin

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract Post-translational modifications, such as lysine acetylation, regulate the activity of diverse proteins across many cellular compartments. Protein deacetylation in mitochondria is catalyzed by the enzymatic activity of the NAD+-dependent dea

Externí odkaz: https://doaj.org/article/b028fc2b6f7e4beeb56bfa8dbba5cc9e

Human Elp3/Kat9 is a mitochondrial tRNA modifying enzyme

Autor: Rachid Boutoual, Hyunsun Jo, Indra Heckenbach, Ritesh Tiwari, Herbert Kasler, Chad A. Lerner, Samah Shah, Birgit Schilling, Vincenzo Calvanese, Matthew J. Rardin, Morten Scheibye-Knudsen, Eric Verdin

Post-translational modifications, such as lysine acetylation, regulate the activity of diverse proteins across many cellular compartments. Protein deacetylation in mitochondria is catalyzed by the enzymatic activity of the NAD+-dependent deacetylase

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40987a70136da768018c1476d0800456
https://doi.org/10.1101/2022.03.24.485634

The MELAS mutation m.3243AG promotes reactivation of fetal cardiac genes and an epithelial-mesenchymal transition-like program via dysregulation of miRNAs

Autor: Carmen Navarro-González, M-Eugenia Armengod, Rachid Boutoual, Magda Villarroya, Salvador Meseguer, Giacomo P. Comi, Joaquin Panadero

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease. 1864(9 Pt)

The pathomechanisms underlying oxidative phosphorylation (OXPHOS) diseases are not well-understood, but they involve maladaptive changes in mitochondria-nucleus communication. Many studies on the mitochondria-nucleus cross-talk triggered by mitochond

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1412a1627038137eb97e42529e691f
https://pubmed.ncbi.nlm.nih.gov/29928977

microRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases

Autor: Olga Boix, Salvador Meseguer, Julio Montoya, Sonia Emperador, Magda Villarroya, Rachid Boutoual, Elena García-Arumí, Carmen Navarro-González, M.-Eugenia Armengod

Publikováno v: Scientific Reports
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
Zaguán. Repositorio Digital de la Universidad de Zaragoza
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Scientific Reports, Vol 7, Iss 1, Pp 1-16 (2017)
r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)

Mitochondrial diseases due to mutations in the mitochondrial (mt) DNA are heterogeneous in clinical manifestations but usually include OXPHOS dysfunction. Mechanisms by which OXPHOS dysfunction contributes to the disease phenotype invoke, apart from

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9c8791bd0994c33967b643c74d2ff69
https://fundanet.cipf.es/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=1316