Zobrazeno 1 - 10 of 29 pro vyhledávání: '"Rachid Berair"'
1
Fibrocyte localisation to the ASM bundle in asthma: bidirectional effects on cell phenotype and behaviour
Autor: Dhananjay Desai, Christopher E. Brightling, Latifa Chachi, Ruth Saunders, Richard D. Thompson, Davinder Kaur, Rachid Berair, Salman Siddiqui
Publikováno v: Clinical & Translational Immunology
Objectives Airway hyper‐responsiveness and persistent airflow obstruction contribute to asthma pathogenesis and symptoms, due in part to airway smooth muscle (ASM) hypercontractility and increased ASM mass. Fibrocytes have been shown to localise to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cae18391323dd61a94ba448d206a3ee
https://doi.org/10.1002/cti2.1205
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2
DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment
Autor: Himanshu Kaul, Amanda Sutcliffe, Ian D. Pavord, Sherif Gonem, Bindi S. Brook, Rod Smallwood, Davinder Kaur, Andrew J. Wardlaw, Latifa Chachi, Michelle Bourne, Christopher E. Brightling, Amisha Singapuri, Richard Kay, Ruth Saunders, Salman Siddiqui, Rachid Berair, Michael Biddle
Publikováno v: Science Translational Medicine. 11(479)
Increased airway smooth muscle mass, a feature of airway remodeling in asthma, is the strongest predictor of airflow limitation and contributes to asthma-associated morbidity and mortality. No current drug therapy for asthma is known to affect airway
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02cb763b096f6d6e49c4130ef6bf5ba
http://ora.ox.ac.uk/objects/uuid:
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3
Myeloid-derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in chronic obstructive pulmonary disease
Autor: Adam K. A. Wright, Sunil Gupta, Bethan Barker, Ruth Saunders, K. Edwards, Christopher E. Brightling, Tracy Thornton, M. Shelley, Ruth Hartley, Katy M. Roach, Vijay Mistry, Rachid Berair, Chris Newby
Publikováno v: Allergy. 72:645-655
The role of fibrocytes in chronic obstructive pulmonary disease (COPD) is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease.Utilizing flow cytometry
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7deb1d29c9abbda5a3aa90c39581ee91
https://doi.org/10.1111/all.13061
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7
Clinical and histological effects of Bronchial Thermoplasty in severe asthma
Autor: Vijay Mistry, Latifa Chachi, Salman Siddiqui, Amisha Singapuri, Paddy Dennison, Stephen Bicknell, Peter H. Howarth, Rachid Berair, Adel H. Mansur, Neil Martin, Richard J. Russell, Christopher E. Brightling, Rekha Chaudhuri
Publikováno v: Interventional Pulmonology.
Background: Bronchial Thermoplasty (BT) has been shown to improve asthma control and symptoms, and reduce exacerbation frequency and rescue medication use. Small studies have shown reduced airway smooth muscle (ASM) mass following BT, but understandi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::167e6b9e7fd2df09f1dd521f3a90527f
https://doi.org/10.1183/1393003.congress-2017.pa3031
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8
Severe asthma: novel advances in the pathogenesis and therapy
Autor: Rachid Berair, Christopher E. Brightling, Ruth Hartley
Publikováno v: Scopus-Elsevier
Asthma affects an estimated 300 million people worldwide and is severe in approximately 10% of sufferers. Asthma, especially severe asthma, is a heterogeneous disease that results from complex host-environment interactions. This review article outlin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a6419d76b9b48fd2a101c0bba7ec0bb
https://doi.org/10.20452/pamw.2253
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9
Airway Smooth Muscle Hypercontractility in Asthma
Autor: Rachid Berair, Christopher E. Brightling, Fay Hollins
Publikováno v: Journal of Allergy
In recent years, asthma has been defined primarily as an inflammatory disorder with emphasis on inflammation being the principle underlying pathophysiological characteristic driving airway obstruction and remodelling. Morphological abnormalities of a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e75d214e1991b5b4605d52ba0bcd79c7
https://doi.org/10.1155/2013/185971
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10
Myeloid derived suppressor cell-like fibrocytes are increased and associated with preserved lung function in COPD
Autor: Ruth Saunders, Rachid Berair, Karen Edwards, Ruth Hartley, Adam K. A. Wright, Vijay Mistry, Chris Newby, Bethan Barker, Sunil Gupta, Katy M. Roach, Tracy Thornton, Christopher E. Brightling, M. Shelley
Publikováno v: 3.3 Mechanisms of Lung Injury and Repair.
Introduction: The role of fibrocytes in COPD is unknown. We sought to enumerate blood and tissue fibrocytes in COPD and determine the association of blood fibrocytes with clinical features of disease. Methods: Utilising flow cytometry to identify cir
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43376bf2d9cc6c3e0a248e9cde24f686
https://doi.org/10.1183/13993003.congress-2016.pa4009
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