Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Rachelle W. Johnson"'
Autor:
Courtney M. Edwards, Jeremy F. Kane, Jailyn A. Smith, Déja M. Grant, Jasmine A. Johnson, Maria A. Hernandez Diaz, Lawrence A. Vecchi, Kai M. Bracey, Tolu N. Omokehinde, Joseph R. Fontana, Breelyn A. Karno, Halee T. Scott, Carolina J. Vogel, Jonathan W. Lowery, T. John Martin, Rachelle W. Johnson
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-17 (2024)
Abstract The role of parathyroid hormone (PTH)-related protein (PTHrP) in breast cancer remains controversial, with reports of PTHrP inhibiting or promoting primary tumor growth in preclinical studies. Here, we provide insight into these conflicting
Externí odkaz:
https://doaj.org/article/560f178405a849319bc2c5abf65d3d90
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100542- (2024)
Externí odkaz:
https://doaj.org/article/8e5b90ed187c476b915b90cf529ba87b
Autor:
Gwenyth J. Joseph, Lawrence A. Vecchi, III, Sasidhar Uppuganti, Margaret Durdan, Wei Chen, David Harrison, Jeffry S. Nyman, Megan Weivoda, Rachelle W. Johnson
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100559- (2024)
Externí odkaz:
https://doaj.org/article/eaad05f7aaa343d0823f044c3b182f4f
Publikováno v:
Journal of Bone Oncology, Vol 45, Iss , Pp 100532- (2024)
Externí odkaz:
https://doaj.org/article/9ae3fe69aae345b7a8bcae6df808ac6b
Publikováno v:
Journal of Bone Oncology, Vol 44, Iss , Pp 100524- (2024)
Epigenetic alterations, including DNA methylation and post translational modifications to histones, drive tumorigenesis and metastatic progression. In the context of bone metastasis, epigenetic modifications in tumor cells can modulate dissemination
Externí odkaz:
https://doaj.org/article/b407e32f78db44ccbb3ccf15893d07ad
Publikováno v:
Journal of Bone Oncology, Vol 43, Iss , Pp 100505- (2023)
Immune checkpoint inhibitors (ICIs) have revolutionized the field of anti-cancer therapy over the last decade; they provide durable clinical responses against tumors by inhibiting immune checkpoint proteins that canonically regulate the T cell-mediat
Externí odkaz:
https://doaj.org/article/5aac685c4b70413f8dedee8a048e90b0
Autor:
Vera M. Todd, Lawrence A. Vecchi, Miranda E. Clements, Katherine P. Snow, Cayla D. Ontko, Lauren Himmel, Christopher Pinelli, Marjan Rafat, Rachelle W. Johnson
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-18 (2021)
Todd et al employ a PyMT-driven spontaneous murine mammary carcinoma model with mammary-specific deletion of hypoxia inducible factors Hif1α, Hif2α, or von Hippel-Lindau factor to further investigate their role in bone and lung metastasis. They fin
Externí odkaz:
https://doaj.org/article/975f1c09009840709de77452a7dc73cb
Autor:
Courtney M. Edwards, Miranda E. Clements, Lawrence A. Vecchi, III, Jasmine A. Johnson, Rachelle W. Johnson
Publikováno v:
Journal of Bone Oncology, Vol 31, Iss , Pp 100407- (2021)
Breast cancer cells frequently disseminate to the bone marrow, where they either induce osteolysis or enter a dormant state. Downregulation of leukemia inhibitory factor receptor (LIFR), a known breast tumor suppressor, enables otherwise dormant MCF7
Externí odkaz:
https://doaj.org/article/50f71f1884954c6ea19fabb61f8bb171
Autor:
Rachelle W. Johnson, Megan M. Weivoda
Publikováno v:
JBMR Plus, Vol 5, Iss 10, Pp n/a-n/a (2021)
Externí odkaz:
https://doaj.org/article/903feb2cdbae4416be191e51d293716c
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Parathyroid hormone related protein (PTHrP) is a multifaceted protein with several biologically active domains that regulate its many roles in normal physiology and human disease. PTHrP causes humoral hypercalcemia of malignancy (HHM) through its end
Externí odkaz:
https://doaj.org/article/d5c881cd88be488bb69cea3633870f28