Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Rachelle M. Toobian"'
Autor:
Laurence Altobell, Trevin Holland, Betty F. Wu, Geoffrey L. Tomlinson, Xue Zhang, Ashley D. Berkebile, Betty Chau, Rachelle M. Toobian, Robert A. Horlick, Steven S. Neben, John L. Macomber, David J. King, Jennifer L. Dalton, Tamlyn Y. Neben, Andy P. Chen, Irina P. Krapf, Heather A. Jones, Audrey D. McConnell, William J. Boyle, Peter Bowers
Publikováno v:
Proceedings of the National Academy of Sciences. 108:20455-20460
A novel approach has been developed for the isolation and maturation of human antibodies that replicates key features of the adaptive immune system by coupling in vitro somatic hypermutation (SHM) with mammalian cell display. SHM is dependent on the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e75ec7744f8b52feb415f2e0ec09038
https://doi.org/10.1073/pnas.1114010108
https://doi.org/10.1073/pnas.1114010108
Autor:
Geoffery L. Tomlinson, Audrey D. McConnell, Peter Bowers, Betty F. Wu, Jennifer L. Dalton, John L. Macomber, Betty Chau, Tamlyn Y. Neben, Robert A. Horlick, David J. King, Petra Verdino, Larry Altobell, Xue Zhang, Rachelle M. Toobian
Publikováno v:
The Journal of biological chemistry. 288(11)
A method for simultaneous humanization and affinity maturation of monoclonal antibodies has been developed using heavy chain complementarity-determining region (CDR) 3 grafting combined with somatic hypermutation in vitro. To minimize the amount of m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c6cc975031adb32c7cda60c0395d6c5
https://pubmed.ncbi.nlm.nih.gov/23355464
https://pubmed.ncbi.nlm.nih.gov/23355464