Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Rachelle J. Bienstock"'
Publikováno v:
Frontiers in Chemistry, Vol 10 (2022)
Azo dyes are defined by the presence of a characteristic N=N group. Sudan I and Sudan II are synthetic azo dyes that have been used as coloring agents. Although animal toxicity studies suggest that Sudan dyes are mutagenic, their molecular mechanism
Externí odkaz:
https://doaj.org/article/cc2398d8092a48c38eb41b7ebe4d661b
Autor:
Rachelle J. Bienstock
Publikováno v:
ACS Pharmacol Transl Sci
Because of the decreased cost and increased ease of whole genome analysis, the diagnosis of rare, orphan diseases has entered a new era. This new technological advance, combined with the worldwide web connections, now permits sharing, searching, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad7d0bbbb6de631343c4ac62c7abee1b
https://pubmed.ncbi.nlm.nih.gov/32259080
https://pubmed.ncbi.nlm.nih.gov/32259080
Autor:
Rachelle J. Bienstock, Veerabahu Shanmugasundaram, Jürgen Bajorath, Ye Hu, Liying Zhang, Christopher Poss, Jared Milbank, Jeremy Starr, Peter Willett, Gerald Maggiora, Vijay Gokhale, Gisbert Schneider, Petra Schneider, Hiromasa Kaneko, Kimito Funatsu, Matheus de Souza Escobar, Héléna A. Gaspar, Pavel Sidorov, Dragos Horvath, Igor I. Baskin, Gilles Marcou, Alexandre Varnek, W. Patrick Walters, Alexander Aronov, Brian Goldman, Brian McClain, Emanuele Perola, Jonathan Weiss, Yufeng J. Tseng, Bo-Han Su, Ming-Tsung Hsu, Olivia A. Lin, Eugen Lounkine, Miguel L. Camargo, Markus Boehm, Nicole Bodycombe, Mateusz Maciejewski, Anne Mai Wassermann
Publikováno v:
DNA Repair. 11:480-487
Ribonucleotide reductase (RNR) is the enzyme critically responsible for the production of the 5′-deoxynucleoside-triphosphates (dNTPs), the direct precursors for DNA synthesis. The dNTP levels are tightly controlled to permit high efficiency and fi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddba9404ad97058470db3f0da0d90d18
https://doi.org/10.1016/j.dnarep.2012.02.001
https://doi.org/10.1016/j.dnarep.2012.02.001
Autor:
Rachelle J. Bienstock
Publikováno v:
Current Drug Metabolism. 18:1240-1254
Novel discoveries in molecular disease pathways within the cell, combined with increasing information regarding protein binding partners has lead to a new approach in drug discovery. There is interest in designing drugs to modulate protein-protein in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e63113ae69a6307d8686c1ef47b0db5
https://doi.org/10.2174/138920012799362891
https://doi.org/10.2174/138920012799362891
Publikováno v:
The Prostate. 72:677-689
BACKGROUND Non-steroidal anti-inflammatory drug-activated gene (NAG-1), a divergent member of the transforming growth factor-beta superfamily, has been implicated in many cellular processes, including inflammation, early bone formation, apoptosis, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6d78c788d092479f08fdfa250ebfdb8
https://doi.org/10.1002/pros.21471
https://doi.org/10.1002/pros.21471
Autor:
Rachelle J. Bienstock
Publikováno v:
Frontiers in Molecular Design and Chemical Information Science-Herman Skolnik Award Symposium 2015: Jürgen Bajorath ISBN: 9780841231412
Frontiers in Molecular Design and Chemical Information Science-Herman Skolnik Award Symposium 2015: Jürgen Bajorath
Frontiers in Molecular Design and Chemical Information Science-Herman Skolnik Award Symposium 2015: Jürgen Bajorath
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba4a503414b1dc406a608d9591d4008a
https://doi.org/10.1021/bk-2016-1222.ch001
https://doi.org/10.1021/bk-2016-1222.ch001
Publikováno v:
Human Molecular Genetics. 16:2729-2739
Mitochondrial DNA is replicated and repaired by DNA polymerase gamma (pol gamma), encoded by the POLG gene. The Y955C substitution in POLG leads to autosomal dominant progressive external ophthalmoplegia (PEO) with other severe phenotypes. PEO patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94ca4776b33312b11c01b7f77075971
https://doi.org/10.1093/hmg/ddm227
https://doi.org/10.1093/hmg/ddm227
Autor:
Jennifer B. Collins, John A. Cidlowski, Rachelle J. Bienstock, Laura J. Lewis-Tuffin, Christine M. Jewell
Publikováno v:
Molecular and Cellular Biology. 27:2266-2282
Human glucocorticoid receptor (hGR) is expressed as two alternately spliced C-terminal isoforms, alpha and beta. In contrast to the canonical hGRalpha, hGRbeta is a nucleus-localized orphan receptor thought not to bind ligand and not to affect gene t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb781b8c939e1962835af8381c1d0c74
https://doi.org/10.1128/mcb.01439-06
https://doi.org/10.1128/mcb.01439-06
Autor:
Rachelle J, Bienstock
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1289
Hydration has a significant impact on ligand binding within protein active sites. Specific water molecules and their placement within protein active sites have been shown to make specific contributions to the energetics of protein-ligand binding and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a70cc1bf10d79a07290fb761b95307dd
https://pubmed.ncbi.nlm.nih.gov/25709028
https://pubmed.ncbi.nlm.nih.gov/25709028