Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Rachelle J Sells Galvin"'
Autor:
Kwi Hye Kim, Jiangang Liu, Rachelle J Sells Galvin, Jeffrey L Dage, Janice A Egeland, Rosamund C Smith, Kalpana M Merchant, Steven M Paul
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142693 (2015)
Fibroblasts from patients with Type I bipolar disorder (BPD) and their unaffected siblings were obtained from an Old Order Amish pedigree with a high incidence of BPD and reprogrammed to induced pluripotent stem cells (iPSCs). Established iPSCs were
Externí odkaz:
https://doaj.org/article/ded9e347a01740cf9e9b97f64d29220f
Autor:
Francis S. Willard, Jonathan A. Lee, Christopher M. Moxham, Tamika D. Meredith, Robert B. Peery, Karen Leigh Cox, Sarah E. Oliver, Jennifer Oler, Steven A. Heidler, Rachelle J. Sells Galvin, Wendy H. Gough, Alan David Palkowitz, Shaoyou Chu, Saba Husain
Publikováno v:
SLAS Discovery. 16:588-602
Phenotypic lead generation strategies seek to identify compounds that modulate complex, physiologically relevant systems, an approach that is complementary to traditional, target-directed strategies. Unlike gene-specific assays, phenotypic assays int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2265c06651bbb3fcdfa65d1c83fae79d
https://doi.org/10.1177/1087057111405379
https://doi.org/10.1177/1087057111405379
Autor:
Timothy Ivo Richardson, Chahrzad Montrose-Rafizadeh, Scott Alan Jones, Terry L. Moore, Thomas J. Bleisch, John J. Osborne, Charles Willis Lugar, Yu Kuo-Long, Jeffrey Alan Dodge, Pamela K. Shetler, Nita J. Patel, Christian Alexander Clarke, Andrew G. Geiser, Jose Eduardo Lopez, Rachelle J. Sells Galvin, Brian Stephen Muehl, Ying K. Yee, Norman Earle Hughes, Richard W. Zink
Publikováno v:
ACS Medicinal Chemistry Letters. 2:148-153
We report the synthesis and characterization of novel 3-aryl indoles as potent and efficacious progesterone receptor (PR) antagonists with potential for the treatment of uterine fibroids. These compounds demonstrated excellent selectivity over other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdb4c9ff42035b27d8602e491bfe9d8
https://doi.org/10.1021/ml100220b
https://doi.org/10.1021/ml100220b
Autor:
Kalpana M. Merchant, Rachelle J. Sells Galvin, Jiangang Liu, Jeffrey L. Dage, Steven M. Paul, Janice A. Egeland, Kwi Hye Kim, Rosamund C. Smith
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142693 (2015)
PLoS ONE
PLoS ONE
Fibroblasts from patients with Type I bipolar disorder (BPD) and their unaffected siblings were obtained from an Old Order Amish pedigree with a high incidence of BPD and reprogrammed to induced pluripotent stem cells (iPSCs). Established iPSCs were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1ccebc18e52efb92ccdee475b809c9d
https://doaj.org/article/ded9e347a01740cf9e9b97f64d29220f
https://doaj.org/article/ded9e347a01740cf9e9b97f64d29220f
Autor:
Srinivasan Chandrashekhar, Edward R. Zartler, Rachelle J. Sells Galvin, Christopher M. Moxham, Tina Fuson, Ajit Regmi, Joanne Kays, Xuhao Yang
Publikováno v:
Bone. 36:284-291
Suramin is a naphthalene trisulfonic acid derivative that inhibits osteoclast differentiation and bone resorption in vitro and in vivo; however, the mechanisms underlying this activity have not been studied. Receptor activator of NF-kB (RANK) ligand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d26a1fe6ec02e8b99dd0a291a30c0345
https://doi.org/10.1016/j.bone.2004.09.022
https://doi.org/10.1016/j.bone.2004.09.022
Novel and Selective Small Molecule Stimulators of Osteoprotegerin Expression Inhibit Bone Resorption
Autor:
Tina Fuson, Srinivasan Chandrasekhar, Rebecca R. Miles, Renee Emkey, David L. Halladay, Rachelle J. Sells Galvin, Yanping Xu, Ricky L. Cain, Henry Uhlman Bryant, T. John Martin, Kannan Thirunavukkarasu, Yanfei L. Ma, Qing Qiang Zeng, Jude E. Onyia, Xuhao Yang
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 309:369-379
Osteoprotegerin (OPG), a secreted member of the tumor necrosis factor receptor superfamily, is a potent inhibitor of osteoclast formation and bone resorption. Because OPG functions physiologically as a locally generated (paracrine) factor, we used hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bb15a45871691a6e00e4f1dfab2a7aa
https://doi.org/10.1124/jpet.103.057893
https://doi.org/10.1124/jpet.103.057893
Autor:
James P. Sluka, Rachelle J. Sells Galvin, L. Ma, L. V. Hale, Jude E. Onyia, J.M. Hock, David L. Halladay, S.R. Patanjali, R. F. Santerre, Rebecca R. Miles, L. Bloem
Publikováno v:
Journal of Cellular Biochemistry. 85:229-242
Parathyroid hormone (PTH) stimulates bone formation in both animals and humans, and the expression of a number of genes has been implicated in the mediation of this effect. To discover new bone factors that initiate and support this phenomenon, we us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457bb5ee5dc27d54c442ced1108855b4
https://doi.org/10.1002/jcb.10129
https://doi.org/10.1002/jcb.10129
Autor:
Xuhao Yang, T. John Martin, Rebeccca R. Miles, Srinivasan Chandrasekhar, David L. Halladay, Jude E. Onyia, Rachelle J. Sells Galvin, Kannan Thirunavukkarasu
Publikováno v:
Journal of Biological Chemistry. 276:36241-36250
Transforming growth factor-β (TGF-β) regulates osteoclastogenesis and osteoclast survival, in part through the induction of osteoprotegerin (OPG), a protein known to inhibit osteoclast formation and function. To explore the molecular basis of TGF-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c23e879b3a449e823e27255b7d4d1c2c
https://doi.org/10.1074/jbc.m104319200
https://doi.org/10.1074/jbc.m104319200
Autor:
James P. Sluka, Rebecca R. Miles, David L. Halladay, R. F. Santerre, Rachelle J. Sells Galvin, Janet M Hock, L. V. Hale, K. Thirunavukkarasu, L. Bloem, J.E. Onyia
Publikováno v:
Endocrinology. 141:4533-4542
PTH stimulates bone formation in animals and humans, and the expressions of a number of genes have been implicated in the mediation of this effect. To discover new bone factors that initiate and support this phenomenon we used differential display RT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56539fb18f05f7ac28dae2d456fa84a
https://doi.org/10.1210/endo.141.12.7817
https://doi.org/10.1210/endo.141.12.7817
Autor:
Kannan Thirunavukkarasu, T. John Martin, Rachelle J. Sells Galvin, Xuhao Yang, Rebecca R. Miles, Jude E. Onyia, David L. Halladay, Srinivasan Chandrasekhar
Publikováno v:
Journal of Biological Chemistry. 275:25163-25172
Bone formation and resorption are tightly coupled under normal conditions, and the interaction of osteoclast precursors with cells of the osteoblast lineage is a prerequisite for osteoclast formation. Cbfa1 is an osteoblast-specific transcription fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f53e6d47edfb2a7496cb84b621a452
https://doi.org/10.1074/jbc.m000322200
https://doi.org/10.1074/jbc.m000322200