Výsledky vyhledávání - "Rachelle G. Veenstra"

B7-H3 expression in donor T cells and host cells negatively regulates acute graft-versus-host disease lethality

Autor: Mark J. Osborn, Katharina Kreymborg, Jonathan S. Serody, James P. Allison, Patricia A. Taylor, Annette Schmitt-Graeff, Cameron McDonald-Hyman, Elisabeth Lieberknecht, Gordon J. Freeman, Marcel R.M. van den Brink, Angela Panoskaltsis-Mortari, Ryan Flynn, Asim Saha, Bruce R. Blazar, William J. Murphy, David H. Munn, Rachelle G. Veenstra, Tak W. Mak, Robert Zeiser

Publikováno v: Blood. 125:3335-3346

Members of the B7 family have been shown to be important for regulating immune responses by providing either positive or negative costimulatory signals. The function of B7-H3 has been controversial. We show that B7-H3 is upregulated in graft-versus-h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61c2d018300e63eebcbba393a33b8a5f
https://doi.org/10.1182/blood-2014-09-603357

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Increased T follicular helper cells and germinal center B cells are required for cGVHD and bronchiolitis obliterans

Publikováno v: Blood. 123:3988-3998

Chronic graft-versus-host disease (cGVHD) is a leading cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Having shown that germinal center (GC) formation and immunoglobulin deposition are required for multiorg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd22bfb1a373f23d1d92d802f5499c3c
https://doi.org/10.1182/blood-2014-03-562231

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Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

Autor: Qing Zhou, Ana C. Anderson, Brenda J. Weigel, Rachelle G. Veenstra, Miyuki Azuma, William J. Murphy, David H. Munn, Vijay K. Kuchroo, Bruce R. Blazar, Meghan E. Munger, Mitsuomi Hirashima

Publikováno v: Blood. 117:4501-4510

Tumor-associated immune suppression can lead to defective T cell-mediated antitumor immunity. Here, we identified a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia (AML). This phenotype is characterized by the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a44e9032bbbb2520232eb2ccca98f847
https://doi.org/10.1182/blood-2010-10-310425

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IL-7 signaling in dendritic cells regulates CD4+ T cell homeostatic proliferation and CD4+ T cell niche size

Autor: Su Young Kim, Melinda S. Merchant, Sema Kurtulus, Yongzhi Cui, Martin Guimond, Hua Zhang, David J. Grindler, Lothar Hennighausen, Crystal L. Mackall, Risu Na, Batu Erman, Polly Matzinger, Ryan D Murphy, Rachelle G. Veenstra

Publikováno v: Nature immunology

Interleukin 7 (IL-7) and T cell antigen receptor signals have been proposed to be the main drivers of homeostatic T cell proliferation. However, it is not known why CD4(+) T cells undergo less-efficient homeostatic proliferation than CD8(+) T cells d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::930186e0428ba4c741cf447012c49658
http://europepmc.org/articles/PMC2713006

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Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality

Autor: Mohammed H. Sayegh, Asim Saha, Bruce R. Blazar, Brent H. Koehn, Gordon J. Freeman, Brian T. Fife, Hideo Yagita, Rafi Ahmed, Miyuki Azuma, Angela Panoskaltsis-Mortari, Arlene H. Sharpe, William J. Murphy, David H. Munn, Rachelle G. Veenstra, Kazutoshi Aoyama, Nader Najafian, Patricia A. Taylor, Gérard Socié

Publikováno v: Blood. 122(17)

Programmed death 1 (PD-1) and its ligands, PD-L1 and PD-L2, play an important role in the maintenance of peripheral tolerance. We explored the role of PD-1 ligands in regulating graft-versus-host disease (GVHD). Both PD-L1 and PD-L2 expression were u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a638e88cdf08c6b2f313bfa7baa7d540
https://pubmed.ncbi.nlm.nih.gov/24030385

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Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells

Autor: Qing Zhou, Terry B. Strom, Rachelle G. Veenstra, Angela Panoskaltsis-Mortari, Ana C. Anderson, Bruce R. Blazar, Vijay K. Kuchroo, Patricia A. Taylor, Mitsuomi Hirashima, Derek Liu, Ryan Flynn

Publikováno v: Blood. 120(3)

T-cell immunoglobulin mucin-3 (Tim-3) is expressed on pathogenic T cells, and its ligand galectin-9 (gal-9) is up-regulated in inflamed tissues. When Tim-3+ T cells encounter high gal-9 levels, they are deleted. Tim-3 is up-regulated on activated T c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191cbc6d00a0e5bf36a048f591fc5140
https://pubmed.ncbi.nlm.nih.gov/22677125

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Thymic stromal lymphopoietin is not necessary or sufficient to mediate the thymopoietic effects of keratinocyte growth factor

Autor: Georg A. Holländer, Crystal L. Mackall, Bruce R. Blazar, Simona W. Rossi, Rachelle G. Veenstra, Martin Guimond, Rosanne Spolski, Warren J. Leonard

Publikováno v: Blood. 111(2)

To the editor: Thymic stromal lymphopoietin (TSLP) is a multifunctional cytokine, produced by epithelial tissues, that signals through TSLP receptors (TSLPRs) and interleukin (IL)-7Rα[1][1] on B- and T-lymphocyte precursors, CD4+ T cells, and dendri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c5106ee1488d8ce44f4bb4532967f0
http://ora.ox.ac.uk/objects/uuid:68ac9bc3-0706-433c-b20a-cb81cc3b834d

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Germinal Center Generation and Maintenance By T Follicular Helper Cells Is Required For The Development Of Chronic Gvhd Associated Bronchiolitis Obliterans In a Preclinical Model

Publikováno v: Blood. 122:292-292

Introduction One obstacle that continues to pose a major risk for hematopoietic stem cell transplantation is the occurrence of chronic graft-versus-host disease (cGVHD). Although the exact cause of cGVHD is unknown, preclinical findings have demonstr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24d18f77036535a330d555ff8c2fc977
https://doi.org/10.1182/blood.v122.21.292.292

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Interleukin-7 Produced by Antigen Presenting Cells Regulates the Homeostatic Peripheral Expansion of Naive CD4 T Cells

Autor: Rachelle G. Veenstra, Melinda S. Merchant, David J. Grindler, Hua Zhang, Martin Guimond, Risu Na, Yongzi Cui, Lothar Hennighausen, Crystal L. Mackall

Publikováno v: Blood. 110:1333-1333

Interleukin-7 (IL-7) is the only cytokine demonstrated thus far to directly support the development and maintenance of naive T cells. Interleukin-7 is produced mainly by the stroma of lymphoid organs but also to a lesser extent by antigen presenting

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e59c12d52c23d116f4b3a3bfa0b7223f
https://doi.org/10.1182/blood.v110.11.1333.1333

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