Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Rachelle Donn"'
Autor:
Adrian H. Heald, Helene A. Fachim, Bilal Bashir, Bethanie Garside, Safwaan Adam, Zohaib Iqbal, Akheel A. Syed, Rachelle Donn, Carel W. Le Roux, Mahmoud Abdelaal, James White, Handrean Soran
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 23, p 16978 (2023)
Bariatric surgery improves dyslipidaemia and reduces body weight, but it remains unclear how bariatric surgery modulates gene expression in fat cells to influence the proprotein convertase subtilisin/kexin type 9 (PCSK-9) and low-density lipoprotein
Externí odkaz:
https://doaj.org/article/cd22fd9cec5b43a0b0921ff4090f3b0b
Autor:
Bethanie Garside, Jan Hoong Ho, See Kwok, Yifen Liu, Shaishav Dhage, Rachelle Donn, Zohaib Iqbal, Simon A. Jones, Handrean Soran
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-7 (2021)
Abstract Background Enzyme replacement therapy (ERT) with olipudase alfa, a recombinant human acid sphingomyelinase (rhASM), is being developed to treat patients with ASM deficiency (ASMD), commonly known as Niemann–Pick disease (NPD) types A or B.
Externí odkaz:
https://doaj.org/article/b7dc6ce787a046a7879d994e777be5c2
Autor:
Helene A. Fachim, Nagaraj Malipatil, Kirk Siddals, Rachelle Donn, Gabriela Y. Cortés, Caroline F. Dalton, J. Martin Gibson, Adrian H. Heald
Publikováno v:
Epigenomes, Vol 6, Iss 1, p 7 (2022)
BDNF signalling in hypothalamic neuronal circuits is thought to regulate mammalian food intake. In light of this, we investigated how a lifestyle intervention influenced serum levels and DNA methylation of BDNF gene in fat tissue and buffy coat of ND
Externí odkaz:
https://doaj.org/article/db21d75df4dd47a4866f820293d6ca91
Autor:
Adrian Heald, Ghasem Yadegarfar, Mark Livingston, Helene Fachim, Ram Prakash Narayanan, Mark Lunt, Kirk Siddals, Gabriela Cortes, Martin Gibson, Rachelle Donn, Simon Anderson, Geoff Hackett, Hugh Jones
Publikováno v:
Artery Research, Vol 25, Iss S1, Pp S178-S179 (2020)
Abstract Background Hypogonadism associates with increased cardiovascular morbidity/mortality in type 2 diabetes mellitus (T2DM) [1]. Increasing CAG repeat number within exon 1 of the androgen receptor gene associates with increased androgen receptor
Externí odkaz:
https://doaj.org/article/d6140b3741864920bbf1eced1d345355
Autor:
Nagaraj S. Malipatil, Ghasem Yadegarfar, Mark Lunt, Brian Keevil, Kirk Siddals, Mark Livingston, Siriol Roberts, Prakash Narayanan, Martin Rutter, J. Martin Gibson, Rachelle Donn, Geoff Hackett, T. Hugh Jones, Adrian Heald
Publikováno v:
Endocrinology, Diabetes & Metabolism, Vol 2, Iss 3, Pp n/a-n/a (2019)
Summary Introduction Hypogonadism is more prevalent in men with type 2 diabetes (T2DM) (25%‐40%) than in men without T2DM. Hypogonadism has been associated with poorer glycaemic outcomes and increased cardiovascular morbidity/mortality. We report a
Externí odkaz:
https://doaj.org/article/0081f6e5b2494e079b256bb12681037a
Autor:
Jan Hoong Ho, Safwaan Adam, Shazli Azmi, Maryam Ferdousi, Yifen Liu, Alise Kalteniece, Shaishav S Dhage, Brian G Keevil, Akheel A Syed, Basil J Ammori, Tomás Ahern, Rachelle Donn, Rayaz A Malik, Handrean Soran
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221992 (2019)
ContextMultiple factors contribute to sexual dysfunction in men with obesity. Sex hormone levels are commonly abnormal in men with obesity and this abnormality is often the focus of management in clinical practice. The role of small fibre neuropathy
Externí odkaz:
https://doaj.org/article/bf9bca4eeb26426d96d99774fc180fb9
Autor:
Rahul Yadav, Salam Hama, Yifen Liu, Tarza Siahmansur, Jonathan Schofield, Akheel A. Syed, Michael France, Philip Pemberton, Safwaan Adam, Jan Hoong Ho, Reza Aghamohammadzadeh, Shaishav Dhage, Rachelle Donn, Rayaz A. Malik, John P. New, Maria Jeziorska, Paul Durrington, Basil A. Ammori, Handrean Soran
Publikováno v:
Frontiers in Immunology, Vol 8 (2017)
PurposeObesity is a major modifiable risk factor for cardiovascular disease. Bariatric surgery is considered to be the most effective treatment option for weight reduction in obese patients with and without type 2 diabetes (T2DM).ObjectiveTo evaluate
Externí odkaz:
https://doaj.org/article/072fb210cd494a048a892c11a31070c4
Autor:
Nagaraj Malipatil, Helene A. Fachim, Kirk Siddals, Bethany Geary, Gwen Wark, Nick Porter, Simon Anderson, Rachelle Donn, Michelle Harvie, Anthony D. Whetton, Martin J. Gibson, Adrian Heald
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 2, p 141 (2019)
We investigated biological determinants that would associate with the response to a diet and weight loss programme in impaired glucose regulation (IGR) people using sequential window acquisition of all theoretical fragment ion spectra (SWATH) mass sp
Externí odkaz:
https://doaj.org/article/4f70e1c1e8d74a7abef930a8cf9c0230
Autor:
Andrew McMaster, Maryam Jangani, Paula Sommer, Namshik Han, Andy Brass, Stephen Beesley, Weiqun Lu, Andrew Berry, Andrew Loudon, Rachelle Donn, David W Ray
Publikováno v:
PLoS ONE, Vol 6, Iss 1, p e15766 (2011)
CONTEXT:Cortisol is released in ultradian pulses. The biological relevance of the resulting fluctuating cortisol concentration has not been explored. OBJECTIVE:Determination of the biological consequences of ultradian cortisol pulsatility. DESIGN:A n
Externí odkaz:
https://doaj.org/article/a620630caa144b97bc2a04f1b3169409
Autor:
Safwaan Adam, Jan H Ho, Yifen Liu, Tarza Siahmansur, Kirk Siddals, Zohaib Iqbal, Shazli Azmi, Siba Senapati, John New, Maria Jeziorska, Basil J Ammori, Akheel A Syed, Rachelle Donn, Rayaz A Malik, Paul N Durrington, Handrean Soran
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 107:2182-2194
Background Emerging evidence suggests an association between impaired high-density lipoprotein (HDL) functionality and cardiovascular disease (CVD). HDL is essential for reverse cholesterol transport (RCT) and reduces inflammation and oxidative stres