Výsledky vyhledávání - "Rachel Willen"

Akademický článek

BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Autor: WonHee Kim, Liang Ma, Selene Lomoio, Rachel Willen, Sylvia Lombardo, Jinghui Dong, Philip G. Haydon, Giuseppina Tesco

Publikováno v: Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2018)

Abstract Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients. Our previous

Externí odkaz: https://doaj.org/article/7258624d78f2453a9df25d037112256f

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Gga3 deletion and a GGA3 rare variant associated with late onset Alzheimer’s disease trigger BACE1 accumulation in axonal swellings

Autor: WonHee Kim, Selene Lomoio, Edward K. Robinson, Giuseppina Tesco, Matthew E. Kennedy, Kevin Z. Ho, Rudolph E. Tanzi, Rachel Willen, Dmitry Prokopenko

Publikováno v: Sci Transl Med

Axonal dystrophy, indicative of perturbed axonal transport, occurs early during Alzheimer’s disease (AD) pathogenesis. Little is known about the mechanisms underlying this initial sign of the pathology. This study proves that Golgi-localized γ-ear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d52c53f890587c8ff4a5f7839cbee36
https://europepmc.org/articles/PMC8612295/

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BACE1 elevation engendered by GGA3 deletion increases β-amyloid pathology in association with APP elevation and decreased CHL1 processing in 5XFAD mice

Autor: Selene Lomoio, Sylvia Lombardo, WonHee Kim, Jinghui Dong, Giuseppina Tesco, Rachel Willen, Liang Ma, Philip G. Haydon

Publikováno v: Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 13, Iss 1, Pp 1-22 (2018)

Background β-site amyloid precursor protein cleaving enzyme 1 (BACE1) is the rate-limiting enzyme in the production of amyloid beta (Aβ), the toxic peptide that accumulates in the brains of Alzheimer’s disease (AD) patients. Our previous studies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27429ef1be7c3dfb6e97491522e5aa46
http://europepmc.org/articles/PMC5796504

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