Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Rachel W. Goehe"'
Autor:
Charles E. Chalfant, Margaret A. Park, Ryan L. Pinkerman, Prabhat Mukerjee, Amy J. Hawkins, Autumn Massiello, Eric K. Mayton, Dayanjan S. Wijesinghe, Charuta S. Murudkar, Rachel W. Goehe, Jacqueline C. Shultz
Increasing evidence points to the functional importance of alternative splice variations in cancer pathophysiology with the alternative pre-mRNA processing of caspase 9 as one example. In this study, we delve into the underlying molecular mechanisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f14ce0313c3cc28bb073939c29b8fa3
https://doi.org/10.1158/1541-7786.c.6541960.v1
https://doi.org/10.1158/1541-7786.c.6541960.v1
Autor:
Charles E. Chalfant, John D. Minna, Jerry W. Shay, Amy J. Hawkins, Charuta Murudkar, D. Shanaka Wijesinghe, Rachel W. Goehe, Jacqueline C. Shultz
Supplementary Figure and Table Legends from Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ad0ef3b4ac2d83bee7f2ac95247dcc1
https://doi.org/10.1158/0008-5472.22384647.v1
https://doi.org/10.1158/0008-5472.22384647.v1
Autor:
Charles E. Chalfant, John D. Minna, Jerry W. Shay, Amy J. Hawkins, Charuta Murudkar, D. Shanaka Wijesinghe, Rachel W. Goehe, Jacqueline C. Shultz
Supplementary Figures 1-10, Tables 1-4 from Alternative Splicing of Caspase 9 Is Modulated by the Phosphoinositide 3-Kinase/Akt Pathway via Phosphorylation of SRp30a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::670a09c4a9ee4bc0a61224e5b7d07e73
https://doi.org/10.1158/0008-5472.22384644
https://doi.org/10.1158/0008-5472.22384644
Autor:
Stefano Toldo, Rachel W Goehe, Marzia Lotrionte, Eleonora Mezzaroma, Evan T Sumner, Giuseppe G L Biondi-Zoccai, Ignacio M Seropian, Benjamin W Van Tassell, Francesco Loperfido, Giovanni Palazzoni, Norbert F Voelkel, Antonio Abbate, David A Gewirtz
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e58421 (2013)
The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this study, we evaluated the toxicity of doxorubicin, non-pegylated liposomal-delivered doxorubicin, and epirubicin in HL-1 adult cardiomyocytes in culture as well
Externí odkaz:
https://doaj.org/article/0039ab5e1fa44fb2948e6b8b53aba441
Autor:
Barbara S. Mallon, Haritha Vallabhaneni, Kye-Yoon Park, Patrick J. Lynch, Guibin Chen, Rachel W. Goehe, Manfred Boehm, Deborah A. Hursh, Yangtengyu Liu
Publikováno v:
Stem Cells. 36:1501-1513
Human induced pluripotent stem cells (iPSCs) have great potential as source cells for therapeutic uses. However, reports indicate that iPSCs carry genetic abnormalities, which may impede their medical use. Little is known about mechanisms contributin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d475a148a187181c0e6b709fc2703251
https://doi.org/10.1002/stem.2861
https://doi.org/10.1002/stem.2861
Autor:
John D. Minna, Rachel W. Goehe, Charuta Murudkar, Charles E. Chalfant, D. Shanaka Wijesinghe, Amy J. Hawkins, Jacqueline C. Shultz, Jerry W. Shay
Publikováno v:
Cancer Research. 70:9185-9196
Increasing evidence points to the functional importance of alternative splice variations in cancer pathophysiology. Two splice variants are derived from the CASP9 gene via the inclusion (Casp9a) or exclusion (Casp9b) of a four-exon cassette. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fdcced3022b1a06d2bdced59e00fff
https://doi.org/10.1158/0008-5472.can-10-1545
https://doi.org/10.1158/0008-5472.can-10-1545
Autor:
Jerry W. Shay, Nadia F. Lamour, Jacqueline C. Shultz, John D. Minna, D. Ross Camidge, Lian Zhang, Davis Massey, Charles E. Chalfant, Sanja Usanovic, Rachel W. Goehe, Charuta Murudkar
Publikováno v:
Journal of Clinical Investigation. 120:3923-3939
Caspase-9 is involved in the intrinsic apoptotic pathway and suggested to play a role as a tumor suppressor. Little is known about the mechanisms governing caspase-9 expression, but post-transcriptional pre-mRNA processing generates 2 splice variants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a618d043e0bb4b36b3d04fed0412c26e
https://doi.org/10.1172/jci43552
https://doi.org/10.1172/jci43552
Autor:
Khushboo Sharma, Rachel W Goehe, Xu Di, Mark Anthony Hicks, Suzy V Torti, Frank M Torti, Hisashi Harada, David A. Gewirtz
The standard of care for unresectable lung cancer is chemoradiation. However, therapeutic options are limited and patients are rarely cured. We have previously shown that vitamin D and vitamin D analogs such as EB 1089 can enhance the response to rad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f41f31002249c25f173a4e510466f28a
https://europepmc.org/articles/PMC4502704/
https://europepmc.org/articles/PMC4502704/
Autor:
Ngoc T. Vu, Rachel W. Goehe, Charles E. Chalfant, Michael D. Shultz, Jacqueline C. Shultz, Margaret A. Park, Sarah A. Smith, Kristen W. Lynch, L. Alexis Hoeferlin
Publikováno v:
The Journal of biological chemistry. 288(12)
Caspase-9 has two splice variants, pro-apoptotic caspase-9a and anti-apoptotic caspase-9b, which are regulated by RNA trans-factors associated with exon 3 of caspase-9 pre-mRNA (C9/E3). In this study, we identified hnRNP U as an RNA trans-factor asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2ff751a0001a773165afa873f3104b9
https://pubmed.ncbi.nlm.nih.gov/23396972
https://pubmed.ncbi.nlm.nih.gov/23396972
Autor:
Benjamin W. Van Tassell, David A. Gewirtz, Marzia Lotrionte, Giuseppe Biondi-Zoccai, Francesco Loperfido, Stefano Toldo, Giovanni Palazzoni, Norbert F. Voelkel, Ignacio M. Seropian, Antonio Abbate, Eleonora Mezzaroma, Evan T. Sumner, Rachel W. Goehe
Publikováno v:
PLoS ONE
PLoS ONE, Vol 8, Iss 3, p e58421 (2013)
PLoS ONE, Vol 8, Iss 3, p e58421 (2013)
Purpose The antineoplastic efficacy of anthracyclines is limited by their cardiac toxicity. In this study, we evaluated the toxicity of doxorubicin, non-pegylated liposomal-delivered doxorubicin, and epirubicin in HL-1 adult cardiomyocytes in culture
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bb99fe65f7708762eb5016794628143
http://hdl.handle.net/11573/525123
http://hdl.handle.net/11573/525123