The application of existing genotoxicity methodologies for grouping of nanomaterials: towards an integrated approach to testing and assessment

Autor: Rachel Verdon, Vicki Stone, Fiona Murphy, Emily Christopher, Helinor Johnston, Shareen Doak, Ulla Vogel, Andrea Haase, Ali Kermanizadeh

Publikováno v: Particle and Fibre Toxicology, Vol 19, Iss 1, Pp 1-9 (2022)

Abstract The incorporation of nanomaterials (NMs) in consumer products has proven to be highly valuable in many sectors. Unfortunately, however, the same nano specific physicochemical properties, which make these material attractive, might also contr

Externí odkaz: https://doaj.org/article/a3e1837ca8fe42b89707349e5fd7bc9b

Application of transgenic zebrafish for investigating inflammatory responses to nanomaterials: Recommendations for new users

Autor: Helinor J Johnston, Suzanne L J Gillies, Rachel Verdon, Vicki Stone, Theodore Henry, Lang Tran, Carl Tucker, Adriano G Rossi, Charles R Tyler

Publikováno v: F1000Research. 12:51

Despite the increasing exploitation of nanomaterials (NMs) in an array of consumer products, there are uncertainties regarding their potential adverse impact on human health. Investigation of whether NMs activate a pro-inflammatory response is routin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::efd437d6c81e48643cd0476f4d47db16
https://doi.org/10.12688/f1000research.128851.1

Neutrophil activation by nanomaterials

Autor: Rachel, Verdon, Suzanne L, Gillies, David M, Brown, Theodore, Henry, Lang, Tran, Charles R, Tyler, Adriano G, Rossi, Vicki, Stone, Helinor J, Johnston

Publikováno v: Nanotoxicology. 15(1)

Assessment of nanomaterial (NM) induced inflammatory responses has largely relied on rodent testing via measurement of leukocyte accumulation in target organs. Despite observations that NMs activate neutrophil driven inflammatory responses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f635d131c08fdeae35c5674cfefa6442
https://pubmed.ncbi.nlm.nih.gov/33272088

Adoption ofin vitrosystems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials

Autor: Rachel Verdon, Charles R. Tyler, Lang Tran, Helinor Jane Johnston, Adriano G. Rossi, Vicki Stone, David M. Brown, Carl S. Tucker, Theodore B. Henry, Suzanne Gillies, Teresa F. Fernandes

Publikováno v: Johnston, H J, Verdon, R, Gillies, S, Brown, D M, Fernandes, T F, Henry, T B, Rossi, A G, Tran, L, Tucker, C, Tyler, C R & Stone, V 2017, ' Adoption of in vitro systems and zebrafish embryos as alternative models for reducing rodent use in assessments of immunological and oxidative stress responses to nanomaterials ', Critical reviews in toxicology, pp. 1-20 . https://doi.org/10.1080/10408444.2017.1404965

Assessing the safety of engineered nanomaterials (NMs) is paramount to the responsible and sustainable development of nanotechnology, which provides huge societal benefits. Currently, there is no evidence that engineered NMs cause detrimental health

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f40af2aed1b3f1fa7e217b698adbcb8
https://doi.org/10.1080/10408444.2017.1404965