Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rachel Tanos"'
Autor:
Athar Khalil, Rachel Tanos, Nehmé El-Hachem, Mazen Kurban, Patrice Bouvagnet, Fadi Bitar, Georges Nemer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract Congenital heart disease is the leading cause of death in the first year of life. Mutations only in few genes have been linked to some cases of CHD. Thalidomide was used by pregnant women for morning sickness but was removed from the market
Externí odkaz:
https://doaj.org/article/159fba6c65b64a8ab565eb39390cea36
Autor:
Iain A. Murray, Ann Kusnadi, Gary H. Perdew, Rachel Tanos, Krishne Gowda, Shantu Amin, Gulsum E. Muku, Guray Kuzu
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology
The ability of the aryl hydrocarbon receptor (AHR) to alter hepatic expression of cholesterol synthesis genes in a DRE-independent manner in mice and humans has been reported. We have examined the influence of functionally distinct classes of AHR lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d74f5060f55a3670f19312b45dbc1b2
http://europepmc.org/articles/PMC6989381
http://europepmc.org/articles/PMC6989381
Autor:
Yvonne Suessmuth, Thomas Cash, Tobey J. MacDonald, Kelly C. Goldsmith, Benjamin Watkins, Muna Qayed, Howard M. Katzenstein, Leslie S. Kean, Cynthia Wetmore, Rachel Tanos, Mourad Tighiouart
Publikováno v:
Pediatric bloodcancerREFERENCES. 67(4)
Background/purpose To determine the maximum tolerated dose, toxicities, and response of sirolimus combined with oral metronomic therapy in pediatric patients with recurrent and refractory solid and brain tumors. Procedure Patients younger than 30 yea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1043b23a7a7476de68d95c9482080886
https://pubmed.ncbi.nlm.nih.gov/31876107
https://pubmed.ncbi.nlm.nih.gov/31876107
Autor:
Rachel Tanos, Sarah Leary, Susan M. Blaney, Kelly C. Goldsmith, Vinay M. Daryani, Clinton F. Stewart, Amar Gajjar, Cynthia Wetmore, James M. Boyett, Catherine A. Billups
Publikováno v:
Cancer Medicine
Sunitinib malate is a small multi‐targeted tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor (VEGFR), platelet‐derived growth factor receptor (PDGFR) and stem cell factor receptor (KIT), which are highly expresse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7068f129cffcd7b22936c2c01ef58245
https://doi.org/10.1002/cam4.713
https://doi.org/10.1002/cam4.713
Autor:
Rachel Tanos, Georges Nemer, Patrice Bouvagnet, Nehme El-Hachem, Fadi Bitar, Mazen Kurban, Athar Khalil
Publikováno v:
Scientific Reports
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Congenital heart disease is the leading cause of death in the first year of life. Mutations only in few genes have been linked to some cases of CHD. Thalidomide was used by pregnant women for morning sickness but was removed from the market because i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be8a6e768bf7fb97b53a145b563619a
http://europepmc.org/articles/PMC5431093
http://europepmc.org/articles/PMC5431093
Autor:
Andrew D. Patterson, Gary H. Perdew, Rushang D. Patel, Iain A. Murray, Philip B. Smith, Rachel Tanos
Publikováno v:
Hepatology. 55:1994-2004
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor belonging to the basic helix-loop-helix (bHLH) – Per ARNT Sim (PAS) family of transcription factors. Ligands for the AHR include the planar, hydrophobic halogenated arom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee001fb2d6566c1eb622ccf9c338b584
https://doi.org/10.1002/hep.25571
https://doi.org/10.1002/hep.25571
Publikováno v:
BMC Cancer
Background Pediatric patients with high-risk neuroblastoma (HR NB) often fail to respond to upfront intensive multimodal therapy. Tumor-acquired suppression of apoptosis contributes to therapy resistance. Many HR NB tumors depend on the anti-apoptoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e994ed73b2fca821d31e81173d6697
https://pubmed.ncbi.nlm.nih.gov/26874859
https://pubmed.ncbi.nlm.nih.gov/26874859
Autor:
Michael D. Hogarty, Kelly C. Goldsmith, Dipan Karmali, Susan K. Peirce, Srilatha Nalluri, Haneen Abdella, Rachel Tanos
Publikováno v:
Cancer biologytherapy. 16(2)
The pediatric solid tumor neuroblastoma (NB) often depends on the anti-apoptotic protein, Mcl(-)1, for survival through Mcl(-)1 sequestration of pro-apoptotic Bim. High affinity Mcl(-)1 inhibitors currently do not exist such that novel methods to inh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b294f87a5c5dabcabe474808e1067560
https://pubmed.ncbi.nlm.nih.gov/25756510
https://pubmed.ncbi.nlm.nih.gov/25756510
Publikováno v:
Toxicological sciences : an official journal of the Society of Toxicology. 129(2)
We have previously demonstrated a role for the aryl hydrocarbon receptor (AHR) in the attenuation of the cholesterol biosynthesis pathway. This regulation did not require that the AHR binds to its cognate response element. Based on these observations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c409e91da78b05c70113e802473371b
https://pubmed.ncbi.nlm.nih.gov/22696238
https://pubmed.ncbi.nlm.nih.gov/22696238
Identification of a high-affinity ligand that exhibits complete aryl hydrocarbon receptor antagonism
Autor:
William H. Bisson, Gary H. Perdew, Michael P. Cooke, John Tellew, Siva Kumar Kolluri, Anthony E. Boitano, Rachel Tanos, Kayla J. Smith, Iain A. Murray
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 338(1)
The biological functions of the aryl hydrocarbon receptor (AHR) can be delineated into dioxin response element (DRE)-dependent or -independent activities. Ligands exhibiting either full or partial agonist activity, e.g., 2,3,7,8-tetrachlorodibenzo-p-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75022dfaf89266512bfdbdeeb37c4c72
https://pubmed.ncbi.nlm.nih.gov/21493753
https://pubmed.ncbi.nlm.nih.gov/21493753