Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rachel Squillace"'
Autor:
Victor M. Rivera, William C. Shakespeare, David Dalgarno, Tim Clackson, Xiaotian Zhu, Juan Miret, Frank Wang, Narayana Narasimhan, Emily Ye, Hyun Gyung Jang, Qurish Mohemmad, Yihan Wang, Dong Zou, Shuangying Liu, Wei-Sheng Huang, Lauren Moran, Lindsey Eichinger, Youngchul Song, David Miller, Scott D. Wardwell, Yaoyu Ning, Jeff Keats, Tianjun Zhou, Sara Nadworny, Rachel Squillace, Rana Anjum, Sen Zhang
Purpose: Non–small cell lung cancers (NSCLCs) harboring ALK gene rearrangements (ALK+) typically become resistant to the first-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitor (TKI) crizotinib through development of secondary r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5126f7a2057f9c47635f6496d280ebf0
https://doi.org/10.1158/1078-0432.c.6525524.v1
https://doi.org/10.1158/1078-0432.c.6525524.v1
Autor:
Victor M. Rivera, William C. Shakespeare, David Dalgarno, Tim Clackson, Xiaotian Zhu, Juan Miret, Frank Wang, Narayana Narasimhan, Emily Ye, Hyun Gyung Jang, Qurish Mohemmad, Yihan Wang, Dong Zou, Shuangying Liu, Wei-Sheng Huang, Lauren Moran, Lindsey Eichinger, Youngchul Song, David Miller, Scott D. Wardwell, Yaoyu Ning, Jeff Keats, Tianjun Zhou, Sara Nadworny, Rachel Squillace, Rana Anjum, Sen Zhang
Supplementary Table 1. Brigatinib in vitro activity (IC50s) in a kinase panel (N=289); Supplementary Figure 1. Chemical structures of brigatinib, crizotinib, ceritinib, and alectinib; Supplementary Figure 2. Brigatinib-mediated inhibition of native o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c6bdb6961073a5b3e650ddfb94203a6
https://doi.org/10.1158/1078-0432.22463789.v1
https://doi.org/10.1158/1078-0432.22463789.v1
Autor:
V.A. Miller, Jeffrey S. Ross, Brian M. Alexander, James Haberberger, Rachel Squillace, Shakti H. Ramkissoon, Geoffrey Kannan, Eric Allan Severson, Andrew Rankin, David E. Kram, Jeffrey Knipstein, Stuart Cramer, Margaret Rosenzweig, Pratheesh Sathyan, Nicholas Britt, Alison Roos, Jo-Anne Vergilio, Rachel L. Erlich, Dean Pavlick, Adrienne Johnson, Siraj M. Ali, Prasanth Reddy
Publikováno v:
Oncologist
RAF family protein kinases signal through the MAPK pathway to orchestrate cellular proliferation, survival, and transformation. Identifying BRAF alterations in pediatric cancers is critically important as therapeutic agents targeting BRAF or MEK may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc09339295f162673c49a98f97be8990
https://pubmed.ncbi.nlm.nih.gov/32918774
https://pubmed.ncbi.nlm.nih.gov/32918774
Autor:
Siraj M. Ali, Juliann Chmielecki, Philip J. Stephens, Doron Lipson, Sumanta K. Pal, Vincent A. Miller, Jamie Buell, Roman Yelensky, Edward Dow, Garrett M. Frampton, Julia A. Elvin, Mark Bailey, Rachel Squillace, Kai Wang, Norma Alonzo Palma, Peter M. Howley, Jeffrey S. Ross, Deborah Morosini, Jie He, Eric M. Sanford
Publikováno v:
The Oncologist. 21:33-39
Background Advanced penile squamous cell carcinoma (PSCC) is associated with poor survival due to the aggressiveness of the disease and lack of effective systemic therapies. Comprehensive genomic profiling (CGP) was performed to identify clinically r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce5a181620d0a1a76ca49b06b616a532
https://doi.org/10.1634/theoncologist.2015-0241
https://doi.org/10.1634/theoncologist.2015-0241
Autor:
Julia A. Elvin, Sai-Hong Ignatius Ou, Siraj M. Ali, Nikita Agarwal, Vincent A. Miller, Sandeep Kodityal, Samuel J. Klempner, Rachel Squillace
Publikováno v:
Lung Cancer. 92:19-21
The emergence of acquired anaplastic lymphoma kinase (ALK) resistant mutations is a common molecular mechanism underpinning disease progression during crizotinib treatment of ALK-positive (ALK+) non-small cell lung cancer (NSCLC) patients. Identifyin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4884e4ec396c589496595378dad5f5f6
https://doi.org/10.1016/j.lungcan.2015.11.023
https://doi.org/10.1016/j.lungcan.2015.11.023
Autor:
Jane J. Yu, Fabrice Roegiers, Rachel Squillace, Emmanuelle Nicolas, Tasha Morrison, Diana Zitserman, Magdalena Karbowniczek, Elizabeth P. Henske, Tiffiney R. Hartman, Damir Khabibullin
Publikováno v:
Journal of Clinical Investigation. 120:93-102
Mutations in either of the genes encoding the tuberous sclerosis complex (TSC), TSC1 and TSC2, result in a multisystem tumor disorder characterized by lesions with unusual lineage expression patterns. How these unusual cell-fate determination pattern
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c59879c8cc8b4b1bef4049befa58071c
https://doi.org/10.1172/jci40221
https://doi.org/10.1172/jci40221
Autor:
Doron Lipson, Sumanta K. Pal, Philip J. Stephens, Vincent A. Miller, Julia A. Elvin, Roman Yelensky, Jose A. Karam, Depinder Khaira, Siraj M. Ali, Adrienne Johnson, Toni K. Choueiri, Kai Wang, Evgeny Yakirevich, Rachel Squillace, Norma Alonzo Palma, Mark N. Stein, Eliezer M. Van Allen, Jeffrey S. Ross, Juliann Chmielecki, Douglas I. Lin
Publikováno v:
European urology. 70(3)
Background Collecting duct carcinoma (CDC) is a rare type of renal cell carcinoma (RCC) originating from the renal medulla. Clinical outcomes are poor, and there are no consensus guidelines to guide therapy. Objective To determine genomic alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ee99724b4681bb2ef6f81f306d8888
https://pubmed.ncbi.nlm.nih.gov/26149668
https://pubmed.ncbi.nlm.nih.gov/26149668