Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Rachel Soloff"'
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mucus secretion is an important feature of asthma that highly correlates with morbidity. Current therapies, including administration of mucolytics and anti-inflammatory drugs, show limited effectiveness and durability, underscoring the need for novel
Externí odkaz:
https://doaj.org/article/9fee9093b2864a16a259f82823701e65
Publikováno v:
Stem Cell Reports, Vol 5, Iss 5, Pp 866-880 (2015)
The number of stem/progenitor cells available can profoundly impact tissue homeostasis and the response to injury or disease. Here, we propose that an atypical PKC, Prkci, is a key player in regulating the switch from an expansion to a differentiatio
Externí odkaz:
https://doaj.org/article/138011b266514dc3b34539eaeb4a11b6
Autor:
Toshimasa Harumoto, Hiroto Iwai, Mari Tanigawa, Toshiko Kubo, Toshiyuki Atsumi, Kyoko Tsutsumi, Michio Takashima, Giuseppe Destito, Rachel Soloff, Kazuma Tomizuka, Corwin Nycholat, James Paulson, Keiji Uehara
Publikováno v:
ACS Chemical Biology. 17:292-298
Extrahepatic targeted delivery of oligonucleotides, such as small interfering RNA (siRNA) and antisense oligonucleotides (ASOs), is an attractive technology for the development of nucleic acid-based medicines. To target CD22-expressing B cells, sever
Autor:
Haruka Miki, David M. Mills, David H. Broide, Carol Feghali-Bostwick, Michael Croft, Rana Herro, Gurupreet S. Sethi, Rachel Soloff, Amit Mehta, Xinh-Xinh Nguyen, Marina Miller
Publikováno v:
J Immunol
Lung fibrosis and tissue remodeling are features of chronic diseases such as severe asthma, idiopathic pulmonary fibrosis, and systemic sclerosis. However, fibrosis-targeted therapies are currently limited. We demonstrate in mouse models of allergen-
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Mucus secretion is an important feature of asthma that highly correlates with morbidity. Current therapies, including administration of mucolytics and anti-inflammatory drugs, show limited effectiveness and durability, underscoring the need for novel
Autor:
Enrique Rodriguez, Benjamin J Schmiedel, Kenneth C. Kalunian, Pandurangan Vijayanand, Andrew J. McKnight, Bharat Panwar, Grégory Seumois, Rachel Soloff, Brandie White, Ferhat Ay, Shu Liang
Publikováno v:
Genome Res
Systemic lupus erythematosus (SLE) is an incurable autoimmune disease disproportionately affecting women. A major obstacle in finding targeted therapies for SLE is its remarkable heterogeneity in clinical manifestations as well as in the involvement
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c8706419841b0363df0b58efab5504
https://europepmc.org/articles/PMC8015858/
https://europepmc.org/articles/PMC8015858/
Autor:
Bharat Panwar, Benjamin J Schmiedel, Grégory Seumois, Kenneth C. Kalunian, Shu Liang, Enrique Rodriguez, Andrew J. McKnight, Pandurangan Vijayanand, Ferhat Ay, Rachel Soloff, Brandie White
The systemic lupus erythematosus (SLE) is an incurable autoimmune disease disproportionately affecting women and may lead to damage in multiple different organs. The marked heterogeneity in its clinical manifestations is a major obstacle in finding t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5eba7f95160355cfae187bb36c0929e
https://doi.org/10.1101/2020.04.27.065227
https://doi.org/10.1101/2020.04.27.065227
Autor:
Rachel Soloff, Charles Wang, Daniel L. Lakeland, Francesca V. Mariani, In Kyoung Mah, Audrey K. Izuhara
Publikováno v:
Dev Biol
Polarized epithelia define boundaries, spaces, and cavities within organisms. Cavitation, a process by which multicellular hollow balls or tubes are produced, is typically associated with the formation of organized epithelia. In order for these epith
Autor:
Toru Miura, Kensuke Myojo, Aihua Song, Kinya Ohgami, Kazuo Suzuki, Rachel Soloff, John Laudenslager, Yutaka Kanda, Daisuke Harada, Reiko Kuni-Kamochi
Publikováno v:
Antiviral Research. 111:60-68
Influenza virus is a global health concern due to its unpredictable pandemic potential. Frequent mutations of surface molecules, hemagglutinin (HA) and neuraminidase (NA), contribute to low efficacy of the annual flu vaccine and therapeutic resistanc
Publikováno v:
The Journal of Experimental Medicine
The E2A proteins, E12 and E47, are required for progression through multiple developmental pathways, including early B and T lymphopoiesis. Here, we provide in vitro and in vivo evidence demonstrating that E47 activity regulates double-positive thymo