Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rachel S, Dakin"'
Autor:
Richard A. Parker, Christopher J. Weir, Tra My Pham, Ian R. White, Nigel Stallard, Mahesh K. B. Parmar, Robert J. Swingler, Rachel S. Dakin, Suvankar Pal, Siddharthan Chandran
Publikováno v:
Trials, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract Background MND-SMART is a platform, multi-arm, multi-stage, multi-centre, randomised controlled trial recruiting people with motor neuron disease. Initially, the treatments memantine and trazodone will each be compared against placebo, but o
Externí odkaz:
https://doaj.org/article/79ee44339d2044749471abb674bbc6f1
Autor:
Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson
Publikováno v:
BMJ Open, Vol 12, Iss 7 (2022)
Introduction Motor neuron disease (MND) is a rapidly fatal neurodegenerative disease. Despite decades of research and clinical trials there remains no cure and only one globally approved drug, riluzole, which prolongs survival by 2–3 months. Recent
Externí odkaz:
https://doaj.org/article/5e965243774d4c02bc888f34d9e8e037
Autor:
Charis Wong, Rachel S Dakin, Jill Williamson, Judith Newton, Michelle Steven, Shuna Colville, Maria Stavrou, Jenna M Gregory, Elizabeth Elliott, Arpan R Mehta, Jeremy Chataway, Robert J Swingler, Richard Anthony Parker, Christopher J Weir, Nigel Stallard, Mahesh K B Parmar, Malcolm R Macleod, Suvankar Pal, Siddharthan Chandran
Publikováno v:
Wong, C, Dakin, R S, Williamson, J, Newton, J, Steven, M, Colville, S, Stavrou, M, Gregory, J M, Elliott, E, Mehta, A R, Chataway, J, Swingler, R J, Parker, R A, Weir, C J, Stallard, N, Parmar, M K B, Macleod, M R, Pal, S & Chandran, S 2022, ' Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease ', BMJ Open, vol. 12, no. 7, pp. e064173 . https://doi.org/10.1136/bmjopen-2022-064173
IntroductionMotor neuron disease (MND) is a rapidly fatal neurodegenerative disease. Despite decades of research and clinical trials there remains no cure and only one globally approved drug, riluzole, which prolongs survival by 2–3 months. Recent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::741cf9191ecd078be98826980c974033
https://www.pure.ed.ac.uk/ws/files/285183479/e064173_MND_SMART.full.pdf
https://www.pure.ed.ac.uk/ws/files/285183479/e064173_MND_SMART.full.pdf
Autor:
Jiangtao Ma, Margaret R Duffy, Lin Deng, Rachel S Dakin, Taco Uil, Jerome Custers, Sharon M Kelly, John H McVey, Stuart A Nicklin, Andrew H Baker
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004673 (2015)
Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX)
Externí odkaz:
https://doaj.org/article/6ac6df5e8e0a463095cf3f42d8085f51
Autor:
Robert A, McDonald, Crawford A, Halliday, Ashley M, Miller, Louise A, Diver, Rachel S, Dakin, Jennifer, Montgomery, Martin W, McBride, Simon, Kennedy, John D, McClure, Keith E, Robertson, Gillian, Douglas, Keith M, Channon, Keith G, Oldroyd, Andrew H, Baker
Publikováno v:
Journal of the American College of Cardiology
Background Drug-eluting stents reduce the incidence of in-stent restenosis, but they result in delayed arterial healing and are associated with a chronic inflammatory response and hypersensitivity reactions. Identifying novel interventions to enhance
Autor:
Vicky King, Brian R. Walker, Jonathan R. Seckl, Jane E. Norman, Amanda J. Drake, Lincoln Liu, Patrick W. F. Hadoke, Rachel S. Dakin
Publikováno v:
Endocrinology. 154:2514-2524
Maternal obesity during pregnancy has been linked to an increased risk of obesity and cardiometabolic disease in the offspring, a phenomenon attributed to developmental programming. Programming effects may be transmissible across generations through
Autor:
Pritam Das, Todd E. Golde, Lisa A. Smithson, Yona Levites, Rachel S. Dakin, Vallie M. Holloway, Karen Jansen
Publikováno v:
The Journal of Neuroscience. 26:11923-11928
Accumulation of amyloid beta protein (Abeta) aggregates is hypothesized to trigger a pathological cascade that causes Alzheimer's disease (AD). Active or passive immunizations targeting Abeta are therefore of great interest as potential therapeutic s
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34
Introduction: Coronary artery bypass surgery is a common surgical procedure. However, 20-50% of patients present vein graft failure within 10 years. The occlusion of the graft is induced by intimal hyperplasia formation promoted by enhanced vascular
Autor:
Taco Gilles Uil, Sharon M. Kelly, Rachel S. Dakin, John H. McVey, Stuart A. Nicklin, Andrew H. Baker, Jiangtao Ma, Jerome Custers, Lin Deng, Margaret R. Duffy
Publikováno v:
PLoS Pathogens, Vol 11, Iss 2, p e1004673 (2015)
PLoS Pathogens
PLoS Pathogens
Adenoviruses are common pathogens, mostly targeting ocular, gastrointestinal and respiratory cells, but in some cases infection disseminates, presenting in severe clinical outcomes. Upon dissemination and contact with blood, coagulation factor X (FX)