Zobrazeno 1 - 10
of 274
pro vyhledávání: '"Rachel R, Caspi"'
Autor:
Pulak R. Nath, Mary Maclean, Vijay Nagarajan, Jung Wha Lee, Mehmet Yakin, Aman Kumar, Hadi Nadali, Brian Schmidt, Koray D. Kaya, Shilpa Kodati, Alice Young, Rachel R. Caspi, Jonas J. W. Kuiper, H. Nida Sen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Birdshot chorioretinopathy is an inflammatory eye condition strongly associated with MHC-I allele HLA-A29. The striking association with MHC-I suggests involvement of T cells, whereas natural killer (NK) cell involvement remains largely unst
Externí odkaz:
https://doaj.org/article/f81206102c384d35a8236de3f769aa55
Autor:
Ha-Na Lee, Biying Xu, Aaron P. Lewkowicz, Kaliroi Engel, Logan Kelley-Baker, Ian L. McWilliams, Derek D.C. Ireland, Jennifer L. Kielczewski, Jinbo Li, Robert N. Fariss, Mercedes M. Campos, Alina Baum, Christos Kyratsous, Kristen Pascal, Chi-Chao Chan, Rachel R. Caspi, Mohanraj Manangeeswaran, Daniela Verthelyi
Publikováno v:
EBioMedicine, Vol 104, Iss , Pp 105170- (2024)
Summary: Background: Ebola virus disease (EVD) survivors experience ocular sequelae including retinal lesions, cataracts, and vision loss. While monoclonal antibodies targeting the Ebola virus glycoprotein (EBOV-GP) have shown promise in improving pr
Externí odkaz:
https://doaj.org/article/22fa242296984e11a7988fdc6dae6cdd
Autor:
Lingjun Zhang, Nozha Borjini, Yu Lun, Sweta Parab, Gospel Asonye, Rupesh Singh, Brent A. Bell, Vera L. Bonilha, Andrei Ivanov, David A. Fox, Rachel R. Caspi, Feng Lin
Publikováno v:
JCI Insight, Vol 7, Iss 18 (2022)
Cub domain-containing protein 1 (CDCP1) is a protein that is highly expressed on the surface of many cancer cells. However, its distribution in normal tissues and its potential roles in nontumor cells are poorly understood. We found that CDCP1 is pre
Externí odkaz:
https://doaj.org/article/f158c9a10c174265a358b644e3a939a7
Autor:
Ruth J. Napier, Ellen J. Lee, Michael P. Davey, Emily E. Vance, João M. Furtado, Paige E. Snow, Kimberly A. Samson, Sydney J. Lashley, Brieanna R. Brown, Reiko Horai, Mary J. Mattapallil, Biying Xu, Michelle C. Callegan, Luke S. Uebelhoer, Christina L. Lancioni, Richard K. Vehe, Bryce A. Binstadt, Justine R. Smith, Rachel R. Caspi, Holly L. Rosenzweig
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription
Externí odkaz:
https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79
Autor:
Ananya Datta, Tiffany Truong, Ji Hyun Lee, Hart Horneman, Orneika Flandrin, Justin Lee, Naren G. Kumar, Rachel R. Caspi, David J. Evans, Suzanne M.J. Fleiszig
Publikováno v:
The Ocular Surface. 28:79-89
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5f8bd64c036f4631424b647a216a040
https://doi.org/10.1016/j.jtos.2023.02.004
https://doi.org/10.1016/j.jtos.2023.02.004
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2021)
Autoimmune uveitis is a major cause of blindness in humans. Activation of retina-specific autoreactive T cells by commensal microbiota has been shown to trigger uveitis in mice. Although a culprit microbe and/or its immunogenic antigen remains to be
Externí odkaz:
https://doaj.org/article/c02fadbfd1004d8aa6621f2c027fdd4c
Autor:
Biying Xu, Jihong Tang, Cancan Lyu, Wambui S. Wandu, Deborah J. Stumpo, Mary J. Mattapallil, Reiko Horai, Igal Gery, Perry J. Blackshear, Rachel R. Caspi
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Non-infectious uveitis, a common cause of blindness in man, is often mediated by autoimmunity, a process in which cytokines play major roles. The biosynthesis and secretion of pro-inflammatory cytokines are regulated in part by tristetraprolin (TTP),
Externí odkaz:
https://doaj.org/article/37d0c877238a4844a13ff9453554a762
Autor:
Jessica Wei, Mary J Mattapallil, Reiko Horai, Yingyos Jittayasothorn, Arnav P Modi, H Nida Sen, Karsten Gronert, Rachel R Caspi
Publikováno v:
eLife, Vol 9 (2020)
The eicosanoid lipoxin A4 (LXA4) has emerging roles in lymphocyte-driven diseases. We identified reduced LXA4 levels in posterior segment uveitis patients and investigated the role of LXA4 in the pathogenesis of experimental autoimmune uveitis (EAU).
Externí odkaz:
https://doaj.org/article/1478210c54f44cb39b611f01a50ed664
Autor:
Ivy M. Dambuza, Chang He, Jin Kyeong Choi, Cheng-Rong Yu, Renxi Wang, Mary J. Mattapallil, Paul T. Wingfield, Rachel R. Caspi, Charles E. Egwuagu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
IL-12p35 is common to IL-35 and IL-12, which have opposing effects on inflammation. Here the authors show that the IL-12p35 subunit induces regulatory B cells and can be used therapeutically to limit autoimmune uveitis in mice.
Externí odkaz:
https://doaj.org/article/4190c1c5e27f46209b8205b45199c5fa
Autor:
Weiwei Wang, Wai Po Chong, Chunmei Li, Zilin Chen, Sihan Wu, Hongyan Zhou, Ying Wan, Wanjun Chen, Igal Gery, Yizhi Liu, Rachel R. Caspi, Jun Chen
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 486-497.e4 (2019)
Summary: Type I interferons (IFNs) have therapeutic potential in CNS autoimmune diseases, such as uveitis, but the molecular mechanisms remain unclear. Using a T cell-transfer model of experimental autoimmune uveitis (EAU), we found that IFN-α/β tr
Externí odkaz:
https://doaj.org/article/61f798c321d94e1cb1fcd2d1a098d3ac