Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Rachel Popow"'
Autor:
Ronald P. DeMatteo, Shan Zeng, Cristina R. Antonescu, Peter Besmer, Ferdinand Rossi, Anson T. Ku, Darren R. Veach, Nagavarakishore Pillarsetty, Rachel Popow, Benjamin L. Green, Megan H. Crawley, Adrian M. Seifert, Jonathan B. Greer, Eric C. Sorenson, Noah A. Cohen, Michael J. Cavnar, Teresa S. Kim
PDF file - 35KB, Supplemental Figure S2. Biodistribution of 99mTc-Sestamibi in KitV558del/+ mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51a93ae013c5422fff7f10245076ff66
https://doi.org/10.1158/1078-0432.22449710.v1
https://doi.org/10.1158/1078-0432.22449710.v1
Autor:
Ronald P. DeMatteo, Shan Zeng, Cristina R. Antonescu, Peter Besmer, Ferdinand Rossi, Anson T. Ku, Darren R. Veach, Nagavarakishore Pillarsetty, Rachel Popow, Benjamin L. Green, Megan H. Crawley, Adrian M. Seifert, Jonathan B. Greer, Eric C. Sorenson, Noah A. Cohen, Michael J. Cavnar, Teresa S. Kim
PDF file - 119KB, Supplemental Figure S1. Additional PLX3397-mediated immune effects.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1afc535094e521ee07be0e5928241e
https://doi.org/10.1158/1078-0432.22449713
https://doi.org/10.1158/1078-0432.22449713
Autor:
Ronald P. DeMatteo, Shan Zeng, Cristina R. Antonescu, Peter Besmer, Ferdinand Rossi, Anson T. Ku, Darren R. Veach, Nagavarakishore Pillarsetty, Rachel Popow, Benjamin L. Green, Megan H. Crawley, Adrian M. Seifert, Jonathan B. Greer, Eric C. Sorenson, Noah A. Cohen, Michael J. Cavnar, Teresa S. Kim
Purpose: Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and a model of targeted molecular therapy. GIST depends on oncogenic KIT signaling and responds to the tyrosine kinase inhibitor imatinib. However, imatinib is rarely cur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07eb8763f0458dbf47679d6cda9d8e35
https://doi.org/10.1158/1078-0432.c.6521732
https://doi.org/10.1158/1078-0432.c.6521732
Publikováno v:
Development
Arl/ARF GTPases regulate ciliary trafficking, but their tissue-specific functions are unclear. Here, we demonstrate that ciliary GTPase Arl3 is required for mitotic spindle orientation of mouse basal stem cells during skin development. Arl3 loss dimi
Autor:
Michael J. Cavnar, Teresa S. Kim, Nagavarakishore Pillarsetty, Anson Ku, Eric C. Sorenson, Rachel Popow, Adrian M. Seifert, Darren R. Veach, Cristina R. Antonescu, Shan Zeng, Noah A. Cohen, Benjamin L. Green, Peter Besmer, Megan H. Crawley, Ferdinand Rossi, Jonathan B. Greer, Ronald P. DeMatteo
Publikováno v:
Clinical Cancer Research. 20:2350-2362
Purpose: Gastrointestinal stromal tumor (GIST) is the most common human sarcoma and a model of targeted molecular therapy. GIST depends on oncogenic KIT signaling and responds to the tyrosine kinase inhibitor imatinib. However, imatinib is rarely cur
Autor:
Benjamin L. Green, Teresa S. Kim, Rachel Popow, Vinod P. Balachandran, Jonathan B. Greer, Megan H. Crawley, Peter Besmer, Ferdinand Rossi, Cristina R. Antonescu, Shan Zeng, Michael J. Cavnar, Noah A. Cohen, Adrian M. Seifert, Lee M. Ocuin, Eric C. Sorenson, Ronald P. DeMatteo
Publikováno v:
The Journal of Experimental Medicine
Imatinib reduces tumor cell KIT signaling and causes tumor cell apoptosis, which drives TAMs to shift from M1- to M2-like in mouse and human GIST.
Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulati
Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulati
Autor:
Michael J. Cavnar, Teresa S. Kim, Rachel Popow, Zubin M. Bamboat, Shan Zeng, Jonathan B. Greer, Eric C. Sorenson, Ronald P. DeMatteo, Lee M. Ocuin
Publikováno v:
Journal of Hepatology. 57:766-773
Background & aims The mitogen-activated protein kinases (MAPKs), c-Jun N-terminal kinase (JNK), and p38, mediate liver ischemia/reperfusion (I/R) injury via cell death and inflammatory cytokine expression, respectively. Nilotinib is an orally availab
Autor:
Hebroon Obaid, Charlotte E. Ariyan, Ferdinand Rossi, Lee M. Ocuin, Shan Zeng, James P. Allison, Zubin M. Bamboat, Jianda Yuan, Rachel Popow, Vinod P. Balachandran, Peter Besmer, Eric C. Sorenson, Jedd D. Wolchok, Ronald P. DeMatteo, Michael J Cavnar, Tianhua Guo, Takahiro Taguchi, Cristina R. Antonescu
Publikováno v:
Nature medicine
Imatinib mesylate targets mutated KIT oncoproteins in gastrointestinal stromal tumor (GIST) and produces a clinical response in 80% of patients. The mechanism is believed to depend predominantly on the inhibition of KIT-driven signals for tumor-cell
Autor:
Rachel Popow, Michael J. Cavnar, Shan Zeng, Lee M. Ocuin, Vinod P. Balachandran, Ronald P. DeMatteo, Eric C. Sorenson
Publikováno v:
Journal of the American College of Surgeons. 213:S142-S143
Autor:
Hebroon Obaid, Lee M. Ocuin, Eric C. Sorenson, Teresa S. Kim, Michael J. Cavnar, Vinod P. Balachandran, Shan Zeng, Rachel Popow, Zubin M. Bamboat, Ronald P. DeMatteo
Publikováno v:
Cancer Research. 73:A94-A94
Introduction: Imatinib mesylate partially exerts its antitumor effects in GIST by inhibiting tumor production of the immunosuppressive enzyme indoleamine 2,3-dioxygenase (Ido), thereby activating antitumor CD8+ T cells. The role of conventional CD4+