Zobrazeno 1 - 10
of 233
pro vyhledávání: '"Rachel Patton"'
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 23, Iss , Pp 2240-2250 (2024)
The 3D conformations of chromosomes can encode biological significance, and the implications of such structures have been increasingly appreciated recently. Certain chromosome structural features, such as A/B compartmentalization, are frequently extr
Externí odkaz:
https://doaj.org/article/0c0697b30ae44fc49d46b7a871f4414d
Publikováno v:
Nucleus, Vol 14, Iss 1 (2023)
ABSTRACTChromatin regions that interact with the nuclear lamina are often heterochromatic, repressed in gene expression, and in the spatial B compartment. However, exceptions to this trend allow us to examine the relative impact of lamin association
Externí odkaz:
https://doaj.org/article/6d358b71f6d745559b64ec3951062b26
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
Abstract Single-cell transcriptomics datasets from the same anatomical sites generated by different research labs are becoming increasingly common. However, fast and computationally inexpensive tools for standardization of cell-type annotation and da
Externí odkaz:
https://doaj.org/article/c7b3a8a0cfcb4cd6bb238b4d11bccbad
Publikováno v:
npj Systems Biology and Applications, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract The boom in single-cell technologies has brought a surge of high dimensional data that come from different sources and represent cellular systems from different views. With advances in these single-cell technologies, integrating single-cell
Externí odkaz:
https://doaj.org/article/e8ac656ab7b4487db899e600e5765504
Autor:
Yang Xu, Rachel Patton McCord
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-4 (2022)
Diagonal integration of multimodal single-cell data emerges as a trending topic. However, empowering diagonal methods for novel biological discoveries requires bridging huge gaps. Here, we comment on potential risks and future directions of diagonal
Externí odkaz:
https://doaj.org/article/52f496add07d410ca5381eb71a8f5830
Autor:
Jacob T. Sanders, Rosela Golloshi, Priyojit Das, Yang Xu, Peyton H. Terry, Darrian G. Nash, Job Dekker, Rachel Patton McCord
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-19 (2022)
Abstract Layers of genome organization are becoming increasingly better characterized, but less is known about how these structures respond to perturbation or shape changes. Low-salt swelling of isolated chromatin fibers or nuclei has been used for d
Externí odkaz:
https://doaj.org/article/b467fe581014489d9d041d7c09c690ef
Autor:
Louis J Gross, Rachel Patton McCord, Sondra LoRe, Vitaly V Ganusov, Tian Hong, W Christopher Strickland, David Talmy, Albrecht G von Arnim, Greg Wiggins
Publikováno v:
PLoS ONE, Vol 18, Iss 4, p e0284982 (2023)
Substantial guidance is available on undergraduate quantitative training for biologists, including reports focused on biomedical science. Far less attention has been paid to the graduate curriculum and the particular challenges of the diversity of sp
Externí odkaz:
https://doaj.org/article/45a865201e244e90a9e3856efbb2868c
Publikováno v:
eLife, Vol 11 (2022)
The expression of a mutant Lamin A, progerin, in Hutchinson-Gilford Progeria Syndrome leads to alterations in genome architecture, nuclear morphology, epigenetic states, and altered phenotypes in all cells of the mesenchymal lineage. Here, we report
Externí odkaz:
https://doaj.org/article/93d35281d3b64f40b9d5391532696c92
Autor:
Yang Xu, Rachel Patton McCord
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-26 (2021)
Abstract Background The rise of spatial transcriptomics technologies is leading to new insights about how gene regulation happens in a spatial context. Determining which genes are expressed in similar spatial patterns can reveal gene regulatory relat
Externí odkaz:
https://doaj.org/article/a995f1817a7e4512823b3f49e5b2f40c
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 8, p e1010392 (2022)
Inside the nucleus, chromosomes are subjected to direct physical interaction between different components, active forces, and thermal noise, leading to the formation of an ensemble of three-dimensional structures. However, it is still not well unders
Externí odkaz:
https://doaj.org/article/f7febf0778b84278bf23c6e92d5e573d