Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Rachel P.-J. Lai"'
Autor:
Elsa du Bruyn, Cari Stek, Remi Daroowala, Qonita Said-Hartley, Marvin Hsiao, Georgia Schafer, Rene T. Goliath, Fatima Abrahams, Amanda Jackson, Sean Wasserman, Brian W. Allwood, Angharad G. Davis, Rachel P.-J. Lai, Anna K. Coussens, Katalin A. Wilkinson, Jantina de Vries, Nicki Tiffin, Maddalena Cerrone, Ntobeko A. B. Ntusi, HIATUS consortium, Catherine Riou, Robert J. Wilkinson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Here the authors describe outcomes of SARS-CoV-2 infection in an African setting of high HIV-1 and tuberculosis prevalence. They find that tuberculosis is a common co-morbidity in patients admitted to hospital with COVID-19 and that the immune respon
Externí odkaz:
https://doaj.org/article/d34350d162f94a06b08193aa90938e4d
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Mycobacterium tuberculosis (Mtb) genes encoding proteins targeted by vaccines and drugs should be expressed in the lung, the main organ affected by Mtb, for these to be effective. However, the pulmonary expression of most Mtb genes and their proteins
Externí odkaz:
https://doaj.org/article/76ba31ced65644ab960217e2702e2944
Autor:
Rachel P. J. Lai, Teresa Cortes, Suzaan Marais, Neesha Rockwood, Melissa L. Burke, Acely Garza-Garcia, Stuart Horswell, Abdul K. Sesay, Anne O’Garra, Douglas B. Young, Robert J. Wilkinson
Publikováno v:
mBio, Vol 12, Iss 6 (2021)
ABSTRACT The crucial transmission phase of tuberculosis (TB) relies on infectious sputum and yet cannot easily be modeled. We applied one-step RNA sequencing (RNA-Seq) to sputum from infectious TB patients to investigate the host and microbial enviro
Externí odkaz:
https://doaj.org/article/a2bdaa3205d34c598027e743e90391af
Autor:
Ursula K. Rohlwink, Anthony Figaji, Katalin A. Wilkinson, Stuart Horswell, Abdul K. Sesay, Armin Deffur, Nico Enslin, Regan Solomons, Ronald Van Toorn, Brian Eley, Michael Levin, Robert J. Wilkinson, Rachel P. J. Lai
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Tuberculosis meningitis (TBM) is a severe form of TB with limited treatment options. Here, the authors perform RNA sequencing on whole blood and on ventricular and lumbar cerebrospinal fluid (CSF) samples from pediatric patients treated for TBM to ch
Externí odkaz:
https://doaj.org/article/11b7cc57037a47a2b99a6a49c4d9e072
Autor:
Angharad G Davis, Sean Wasserman, Cari Stek, Mpumi Maxebengula, C Jason Liang, Stephani Stegmann, Sonya Koekemoer, Amanda Jackson, Yakub Kadernani, Marise Bremer, Remy Daroowala, Saalikha Aziz, Rene Goliath, Louise Lai Sai, Thandi Sihoyiya, Paolo Denti, Rachel P J Lai, Thomas Crede, Jonathan Naude, Patryk Szymanski, Yakoob Vallie, Ismail Abbas Banderker, Muhammed S Moosa, Peter Raubenheimer, Sally Candy, Curtis Offiah, Gerda Wahl, Isak Vorster, Gary Maartens, John Black, Graeme Meintjes, Robert J Wilkinson
Background Drug regimens that include intensified antibiotics alongside effective anti-inflammatory therapies may improve outcomes in tuberculous meningitis (TBM). Safety data on their use in combination and in the context of human immunodeficiency v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c42911404e9e173481f72774be3e0f3f
Autor:
Paolo Denti, John A. Joska, Gerda Wahl, Shiraz Moosa, John H. Black, Robert J. Wilkinson, Louise Lai Sai, Marise Bremer, Ernesta M. Meintjes, Graeme Meintjes, Sally Candy, Patryk Szymanski, Saalikha Aziz, Lori E. Dodd, Rene Goliath, Frances Robertson, Cari Stek, Ismail Banderker, Anna J. Dreyer, Sean Wasserman, Isak D Vorster, Amanda Jackson, Yakub E Kadernani, Sam Nightingale, Jonathan Naude, Angharad G Davis, Gary Maartens, Thomas Crede, C.Jason Liang, Peter J Raubenheimer, Remy Daroowala, Yakoob Vallie, Mpumi Maxebengula, Rachel P. J. Lai, Stephani Stegmann, Sonya Koekemoer, Thandi Sihoyiya, Curtis Offiah
Publikováno v:
Wellcome Open Research
Background: Tuberculous meningitis (TBM) is the most lethal form of tuberculosis with a mortality of ~50% in those co-infected with HIV-1. Current antibiotic regimens are based on those known to be effective in pulmonary TB and do not account for the
Autor:
Clément Frainay, Pablo Rodriguez-Mier, Juliette Cooke, Fabien Jourdan, Florence Vinson, Cecilia Wieder, Timothy M. D. Ebbels, Nathalie Poupin, Rachel P. J. Lai, Jacob G. Bundy
Over-representation analysis (ORA) is one of the commonest pathway analysis approaches used for the functional interpretation of metabolomics datasets. Despite the widespread use of ORA in metabolomics, the community lacks guidelines detailing its be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3dce225e6388f1ff7dd8b67bce884e
https://hal.archives-ouvertes.fr/hal-03240376/file/2021-BioRxiv-ORA-2021.05.24.445406v1.full.pdf
https://hal.archives-ouvertes.fr/hal-03240376/file/2021-BioRxiv-ORA-2021.05.24.445406v1.full.pdf
Autor:
Elsa du Bruyn, Cari Stek, Remi Daroowala, Qonita Said-Hartley, Marvin Hsiao, Rene T. Goliath, Fatima Abrahams, Amanda Jackson, Sean Wasserman, Brian W Allwood, Angharad G. Davis, Rachel P-J. Lai, Anna K. Coussens, Katalin A. Wilkinson, Jantina de Vries, Nicki Tiffin, Maddalena Cerrone, Ntobeko A. B. Ntusi, Catherine Riou, Robert J. Wilkinson, Saalikha Aziz, Nonzwakazi Bangani, John Black, Marise Bremer, Wendy Burgers, Zandile Ciko, Hanif Esmail, Siamon Gordon, Yolande X. R. Harley, Francisco Lakay, Fernando-Oneissi Martinez-Estrada, Graeme Meintjes, Marc Mendelson, Tari Papavarnavas, Alize Proust, Sheena Ruzive, Georgia Schafer, Keboile Serole, Claire Whitaker, Kennedy Zvinairo
ObjectivesTo describe the presentation and outcome of SARS-CoV2 infection in an African setting of high non-communicable co-morbidity and also HIV-1 and tuberculosis prevalence.DesignCase control analysis with cases stratified by HIV-1 and tuberculos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42134c3089f3a49018a9eac90abf73bf
https://doi.org/10.1101/2021.05.11.21256479
https://doi.org/10.1101/2021.05.11.21256479
Autor:
Armin Deffur, Abdul Karim Sesay, Regan Solomons, Nico Enslin, Ursula K. Rohlwink, Robert J. Wilkinson, Michael Levin, Ronald van Toorn, Katalin A. Wilkinson, Stuart Horswell, Rachel P. J. Lai, Anthony Figaji, Brian Eley
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Nature Communications
Nature Communications
Tuberculous meningitis (TBM) is the most severe form of TB with high rates of mortality and morbidity. Here we conduct RNA-sequencing on whole blood as well as on ventricular and lumbar cerebrospinal fluid (CSF) of pediatric patients treated for TBM.
Autor:
Deborah Schneider-Luftman, Robert J. Wilkinson, Katalin A. Wilkinson, Gavin Kelly, Nishtha Jhilmeet, Rachel P. J. Lai, David M. Lowe, Christopher Barrington
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Antiretroviral treatment (ART) reduces the risk of developing active tuberculosis (TB) in HIV-1 co-infected persons. In order to understand host immune responses during ART in the context of Mycobacterium tuberculosis (Mtb) sensitization, we performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c68e8961bcfe701a401c9d5555b6bce
https://doi.org/10.1101/2020.11.13.20231274
https://doi.org/10.1101/2020.11.13.20231274