Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Rachel Ozeri"'
Autor:
Michael Shokhen, Netaly Khazanov, Rachel Ozeri, Nurit Perlman, Tamar Traube, Michal Hirsch, Amnon Albeck, S. Vijayakumar
Publikováno v:
Israel Journal of Chemistry. 54:1137-1151
Mechanistic studies of catalysis and the inhibition of serine and cysteine proteases afford new and sometimes surprising insights, challenging conventional dogmas in enzymology. The intrinsic source of the difference in the catalytic mechanisms of se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::046927094636308d1e9b255ed2cc94b0
https://doi.org/10.1002/ijch.201300144
https://doi.org/10.1002/ijch.201300144
Autor:
Alex Aizikovich, Alexander Konson, Nili Schutz, Alina Shitrit, Avihai Yacovan, Sima Mirilashvili, Rachel Ozeri, Daniel Sherman, Osnat Bohana-Kashtan, Oren M. Becker, Tzofit Kehat, Vered Behar, Efrat Ben-Zeev
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6460-6468
Cancer cells preferentially use glycolysis rather than oxidative phosphorylation for their rapid growth. They consume large amount of glucose to produce lactate even when oxygen is abundant, a phenomenon known as the Warburg effect. This metabolic ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79338c894668e99725151e301339abfd
https://doi.org/10.1016/j.bmcl.2012.08.054
https://doi.org/10.1016/j.bmcl.2012.08.054
Publikováno v:
ChemMedChem. 1:631-638
A transition-state analogue inhibitor that covalently reversibly binds to an enzyme formally consists of two parts: the chemical site, CS and the recognition site, RS. We have experimentally and theoretically demonstrated that the trend of binding af
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4183cfb3dbd01a840547a4ef6ee463e6
https://doi.org/10.1002/cmdc.200600029
https://doi.org/10.1002/cmdc.200600029
Autor:
Vered Behar, Efrat Ben-Zeev, Avihai Yacovan, Alexander Konson, Sima Mirilashvili, Osnat Bohana-Kashtan, Nili Schutz, Alina Shitrit, Oren M. Becker, Tzofit Kehat, Rachel Ozeri
Publikováno v:
Cancer Research. 72:3219-3219
Pyruvate kinase (PK) M2 which catalyzes the last step in glycolysis, is the alternative spliced isoform expressed in cancer cells, and a key player in exerting the Warburg effect. One of the mechanisms by which PKM2 modulate cancer cell metabolism is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6ebf05a900bd11a04cfadce492af3cd
https://doi.org/10.1158/1538-7445.am2012-3219
https://doi.org/10.1158/1538-7445.am2012-3219