Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Rachel N Arey"'
Autor:
Ashley N Hayden, Katie L Brandel, Edward W Pietryk, Paul R Merlau, Priyadharshini Vijayakumar, Emily J Leptich, Elizabeth S Gaytan, Meredith I Williams, Connie W Ni, Hsiao-Tuan Chao, Jill A Rosenfeld, Rachel N Arey
Publikováno v:
PLoS Genetics, Vol 20, Iss 10, p e1011443 (2024)
RNA-binding proteins (RBPs) regulate translation and plasticity which are required for memory. RBP dysfunction has been linked to a range of neurological disorders where cognitive impairments are a key symptom. However, of the 2,000 RBPs in the human
Externí odkaz:
https://doaj.org/article/01f6db9a6ca645daa5e34366e5a3f326
Publikováno v:
Biochemical Society Transactions. 51:161-171
How organisms learn and encode memory is an outstanding question in neuroscience research. Specifically, how memories are acquired and consolidated at the level of molecular and gene pathways remains unclear. In addition, memory is disrupted in a wid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::762d9db8389aa4b42db1f66025438e83
https://doi.org/10.1042/bst20220455
https://doi.org/10.1042/bst20220455
Autor:
Heehwa G. Son, Mihwa Seo, Seokjin Ham, Wooseon Hwang, Dongyeop Lee, Seon Woo A. An, Murat Artan, Keunhee Seo, Rachel Kaletsky, Rachel N. Arey, Youngjae Ryu, Chang Man Ha, Yoon Ki Kim, Coleen T. Murphy, Tae-Young Roh, Hong Gil Nam, Seung-Jae V. Lee
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
The decline of DNA and protein quality control contributes to organismal ageing. Here, Sonet al. report that nonsense-mediated mRNA decay, a RNA quality control mechanism, is enhanced in long-lived daf-2 mutant worms and contributes to their longevit
Externí odkaz:
https://doaj.org/article/0c9bbbde0d4b4ce0a1014b73350edcc7
Genome-wide association studies (GWAS) have uncovered over 40 genomic loci associated with risk for late-onset Alzheimer's Disease (LOAD), but identification of the underlying causal genes remains challenging. While the role of glial biology in the m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19ccc5000635b05608e5e7583f96d5d2
https://doi.org/10.1101/2022.08.19.504537
https://doi.org/10.1101/2022.08.19.504537
Autor:
Terytty Yang Li, Arwen W. Gao, Xiaoxu Li, Yasmine J. Liu, Rachel N. Arey, Kimberly Morales, Amélia Lalou, Qi Wang, Tanes Lima, Johan Auwerx
SUMMARYLysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homeostasis and health. Here, we discovered an adaptive lysosomal transcriptional response that we termed the Lysosomal Surveillance Respon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dff5252bd7e5c582e38600e1a8453f17
https://doi.org/10.1101/2022.06.13.495962
https://doi.org/10.1101/2022.06.13.495962
Autor:
Evan Y. Snyder, Angela R. Ozburn, Colleen A. McClung, Mariah A. Hildebrand, George C. Tseng, Jeffrey Oliver-Smith, Matthew B Jarpe, Alicia M. Winquist, Hui Zhang, Wei Zong, Puja K. Parekh, Darius Becker-Krail, Zhiguang Huo, Ethan Fitzgerald, Rachel N. Arey, Xiyu Zhu, Lauren M. DePoy, Andrew Crain, Kyle D. Ketchesin, Brian T. D. Tobe, Xiangning Xue, Ryan W. Logan
Publikováno v:
Molecular psychiatry
Valproate (VPA) has been used in the treatment of bipolar disorder since the 1990s. However, the therapeutic targets of VPA have remained elusive. Here we employ a preclinical model to identify the therapeutic targets of VPA. We find compounds that i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3c998801c8fc52a7971dd952089690
http://europepmc.org/articles/PMC8141541
http://europepmc.org/articles/PMC8141541
Publikováno v:
Comparative biochemistry and physiology. Part A, Molecularintegrative physiology. 267
As human life expectancy increases, neurodegenerative diseases present a growing public health threat, for which there are currently few effective treatments. There is an urgent need to understand the molecular and genetic underpinnings of these diso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8282db6d35e36630a177418c2cb312cb
https://pubmed.ncbi.nlm.nih.gov/35176489
https://pubmed.ncbi.nlm.nih.gov/35176489
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Presynaptic protein synthesis is important in the adult central nervous system; however, the nervous system-wide set of mRNAs localized to presynaptic areas has yet to be identified in any organism. Here we differentially labeled somatic and synaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de176b53a7516a4c99846149c7873292
https://doi.org/10.1038/s41598-019-56908-8
https://doi.org/10.1038/s41598-019-56908-8
Presynaptic protein synthesis is important in the adult central nervous system; however, the set of mRNAs localized to presynaptic areas has yet to be identified in any organism. We differentially labeled somatic and synaptic compartments nervous sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b38299cb9269ba75561d0173dcbbbb5e