Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Rachel Michelle, Saré"'
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Many patients with fragile X syndrome (FXS) have sleep disturbances, and Fmr1 knockout (KO) mice (a model of FXS) have reduced sleep duration compared to wild type (WT). Sleep is important for brain development, and chronic sleep restriction during d
Externí odkaz:
https://doaj.org/article/b862f6b86b2a4b578a8f340b7ff93677
Publikováno v:
Neurobiology of Disease, Vol 159, Iss , Pp 105485- (2021)
Fragile X Syndrome (FXS) is caused by silencing the FMR1 gene which results in intellectual disability, hyperactivity, sensory hypersensitivity, autistic-like behavior, and susceptibility to seizures. This X-linked disorder is also associated with re
Externí odkaz:
https://doaj.org/article/b090f63367e046bca7d8ce9077f039f8
Publikováno v:
Neurobiology of Disease, Vol 148, Iss , Pp 105213- (2021)
SHANK3 is a postsynaptic scaffolding protein that plays a critical role in synaptic development and brain function. Mutations in SHANK3 are implicated in Phelan-McDermid syndrome (PMS), a neurodevelopmental disorder characterized by autistic-like beh
Externí odkaz:
https://doaj.org/article/ec1330e02d8b458b948697369089c17b
Autor:
Rachel Michelle Saré, Spencer K. Cooke, Leland Krych, Patricia M. Zerfas, Robert M. Cohen, Carolyn Beebe Smith
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
Alzheimer’s disease (AD) is a progressive neurodegenerative disease resulting in cognitive decline. A unique rat model, TgF344-AD, recapitulates pathological hallmarks of AD. We used a longitudinal design to address the timing of expression of beha
Externí odkaz:
https://doaj.org/article/9d70688e83e94176bae91698f01495f3
Autor:
Rachel Michelle Saré, Alex Song, Merlin Levine, Abigail Lemons, Inna Loutaev, Carrie Sheeler, Christine Hildreth, Angel Mfon, Spencer Cooke, Carolyn Beebe Smith
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 13 (2019)
Sleep abnormalities are prevalent in autism spectrum disorders (ASD). Moreover, the severity of ASD symptoms are correlated with the degree of disturbed sleep. We asked if disturbed sleep during brain development itself could lead to ASD-like symptom
Externí odkaz:
https://doaj.org/article/43056dd9d493466a91fd0ed2827e997d
Publikováno v:
Brain Sciences, Vol 11, Iss 4, p 522 (2021)
Rodent models of brain disorders including neurodevelopmental, neuropsychiatric, and neurodegenerative diseases are essential for increasing our understanding of underlying pathology and for preclinical testing of potential treatments. Some of the mo
Externí odkaz:
https://doaj.org/article/c7a532eaee71472b8633b02a363a5a76
Publikováno v:
Brain Sciences, Vol 11, Iss 1, p 31 (2020)
Sleep abnormalities are common in patients with neurodevelopmental disorders, and it is thought that deficits in sleep may contribute to the unfolding of symptoms in these disorders. Appreciating sleep abnormalities in neurodevelopmental disorders co
Externí odkaz:
https://doaj.org/article/82df0c1f83f04be197ad48f208371af0
Autor:
Rachel Michelle Saré, Christopher Figueroa, Abigail Lemons, Inna Loutaev, Carolyn Beebe Smith
Publikováno v:
Brain Sciences, Vol 9, Iss 1, p 13 (2019)
Fragile X syndrome (FXS) is caused by silencing of the FMR1 gene leading to loss of the protein product fragile X mental retardation protein (FMRP). FXS is the most common monogenic cause of intellectual disability. There are two known mammalian para
Externí odkaz:
https://doaj.org/article/3742287e08b74c718e2ab0adb3563d6e
Publikováno v:
eNeuro.
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that results in intellectual disability and, in ∼50% of patients, autism spectrum disorder. The protein products that are altered in TSC (TSC1 and TSC2) form a complex to inhibit th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9642fb4325ff004d06d70caf24482582
https://pubmed.ncbi.nlm.nih.gov/35851298
https://pubmed.ncbi.nlm.nih.gov/35851298
Publikováno v:
eneuro. 9:ENEURO.0480-21.2022
Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that results in intellectual disability and, in ∼50% of patients, autism spectrum disorder. The protein products that are altered in TSC (TSC1 and TSC2) form a complex to inhibit th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6c42eb450743d1f6e16deb83f5e809b
https://doi.org/10.1523/eneuro.0480-21.2022
https://doi.org/10.1523/eneuro.0480-21.2022