Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Rachel Martinelli"'
Autor:
Liang Chen, Michael C. Zody, Clara Di Germanio, Rachel Martinelli, Jose R. Mediavilla, Marcus H. Cunningham, Kaelea Composto, Kar Fai Chow, Milena Kordalewska, André Corvelo, Dayna M. Oschwald, Samantha Fennessey, Marygrace Zetkulic, Sophia Dar, Yael Kramer, Barun Mathema, Soren Germer, Mars Stone, Graham Simmons, Michael P. Busch, Tom Maniatis, David S. Perlin, Barry N. Kreiswirth
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
Over a year of the COVID-19 pandemic, distinct severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lineages have arisen in multiple geographic areas around the world. SARS-CoV-2 variants of concern (VOCs), i.e., B.1.1.7 (alpha), B.1.351 (bet
Externí odkaz:
https://doaj.org/article/435e559185594cb0b1ba92dd648cebd3
Autor:
Kritika Khanna, Wilfred W. Raymond, Jing Jin, Annabelle R. Charbit, Irina Gitlin, Monica Tang, Adam D. Werts, Edward G. Barrett, Jason M. Cox, Sharla M. Birch, Rachel Martinelli, Hannah S. Sperber, Sergej Franz, Thomas Duff, Markus Hoffmann, Anne Marie Healy, Stefan Oscarson, Stefan Pöhlmann, Satish K. Pillai, Graham Simmons, John V. Fahy
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 323:L372-L389
The redox status of the cysteine-rich SARS-CoV-2 spike glycoprotein (SARS-2-S) is important for the binding of SARS-2-S to angiotensin-converting enzyme 2 (ACE2), suggesting that drugs with a functional thiol group (“thiol drugs”) may cleave cyst
Autor:
Thomas Gniadek, Clara Di Germanio, Mars Stone, Graham Simmons, Michael P. Busch, Rachel Martinelli, Chloe Thorbrogger
Publikováno v:
Transfusion. 62:563-569
BackgroundCOVID-19 convalescent plasma (CCP) was widely used as passive immunotherapy during the first waves of SARS-CoV-2 infection in the US. However, based on observational studies and randomized controlled trials, beneficial effects of CCP were l
Autor:
Daniel J. Capon, Larisa Troitskaya, Nelson Lap Shun Chan, Marina Fomin, Ursula Edman, Brendon Frank, Jing Jin, Rachel Martinelli, Benjamin Z. Capon, Ginger A. Ferguson, Malcolm L. Gefter, Graham Simmons
The ability of antibodies and Fc-fusion proteins to bind multiple targets cooperatively is limited by their topology. Here we describe our discovery that ACE2 Fc-fusion proteins spontaneously cross-dimerize, forming topologically distinct “superdim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba62b122f626d16857231cf213e8ee67
https://doi.org/10.1101/2022.03.23.485397
https://doi.org/10.1101/2022.03.23.485397
Autor:
André Corvelo, Kaelea Composto, Sophia Dar, Clara Di Germanio, José R. Mediavilla, Dayna M. Oschwald, Soren Germer, David S. Perlin, Yael Kramer, Samantha Fennessey, Tom Maniatis, Michael C. Zody, Marygrace Zetkulic, Barry N. Kreiswirth, Liang Chen, Kar Fai Chow, Graham Simmons, Milena Kordalewska, Barun Mathema, Mars Stone, Marcus H Cunningham, Michael P. Busch, Rachel Martinelli
Publikováno v:
mSphere, Vol 6, Iss 4 (2021)
mSphere
mSphere
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs), harboring spike protein N-terminal domain (NTD) or receptor-binding domain (RBD) mutations, exhibit reduced in vitro susceptibility to convalescent-phase serum,
Autor:
James Gomez, Kathleen Kelly, Clara Di Germanio, Mahzad Azimpouran, Jonathan Livny, Orsolya Darst, Deborah T. Hung, Rachel Martinelli, Marek Orzechowski, Ralph R. Vassallo, Peijun Ma, Kelsey Hazegh, Michael P. Busch, Eduard Grebe, Shuting Zhang, Graham Simmons, Mars Stone, Larry J. Dumont
Publikováno v:
Transfusion
Background Antibody response duration following severe acute respiratory syndrome coronavirus 2 infection tends to be variable and depends on severity of disease and method of detection. Study design and methods COVID‐19 convalescent plasma from 18
Autor:
Kathleen Kelly, Clara Di Germanio, Kelsey Hazegh, Orsolya Darst, Mahzad Azimpouran, Shuting Zhang, Graham Simmons, Jonathan Livny, Deborah T. Hung, Ralph R. Vassallo, Rachel Martinelli, Marek Orzechowski, Eduard Grebe, Mars Stone, Larry J. Dumont, Peijun Ma, Michael P. Busch
BackgroundAntibody response duration following SARS-CoV-2 infection tends to be variable and depends on severity of disease and method of detection.Study design and methodsCOVID-19 convalescent plasma (CCP) from 18 donors was collected longitudinally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::205abe904b1e914edd0d2ddfde445f00
https://doi.org/10.1101/2021.03.24.21254260
https://doi.org/10.1101/2021.03.24.21254260
Autor:
Kritika, Khanna, Wilfred, Raymond, Jing, Jin, Annabelle R, Charbit, Irina, Gitlin, Monica, Tang, Adam D, Werts, Edward G, Barrett, Jason M, Cox, Sharla M, Birch, Rachel, Martinelli, Hannah S, Sperber, Sergej, Franz, Satish, Pillai, Anne Marie, Healy, Thomas, Duff, Stefan, Oscarson, Markus, Hoffmann, Stefan, Pöhlmann, Graham, Simmons, John V, Fahy
Publikováno v:
bioRxiv : the preprint server for biology.
Neutrophil-induced oxidative stress is a mechanism of lung injury in COVID-19, and drugs with a functional thiol group ("thiol drugs"), especially cysteamine, have anti-oxidant and anti-inflammatory properties that could limit this injury. Thiol drug