Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Rachel M. McKenna"'
Autor:
James Gough, John Jeffery, Peter Nickerson, Kim Solez, David N. Rush, Kiril Trpkov, Rachel M. McKenna
Publikováno v:
Scopus-Elsevier
Background There is evidence that biopsy of stable renal allografts may be of value in predicting chronic allograft nephropathy, the main cause of graft loss. However, the reproducibility of such histological evaluation has not been tested in this se
Autor:
Rachel M. McKenna, Paul C. Grimm, James Gough, E. Stern, John Jeffery, Rashmin C. Savani, David N. Rush, Peter Nickerson
Publikováno v:
New England Journal of Medicine. 345:93-97
Tissue remodeling depends on mesenchymal cells (fibroblasts and myofibroblasts) and is a prominent feature of chronic renal-transplant rejection. It is not known whether the mesenchymal cells that participate in remodeling originate locally or from c
Publikováno v:
Transplantation. 69:319-326
We have cited more than 23 studies showing that de novo development of anti-HLA antibodies is associated with increased acute and chronic rejection and decreased graft survival in kidney, heart, lung, liver, and corneal transplants. Antibodies to bot
Autor:
John Jeffery, Peter Nickerson, Paul C. Grimm, J Gough, Rachel M. McKenna, Patricia E. Birk, David N. Rush
Publikováno v:
Pediatric Transplantation. 3:257-270
Despite improvements in the prevention and treatment of acute renal allograft rejection, the long-term survival of renal transplants has not increased. Immunologic and non-immunologic factors contribute to the gradual deterioration of graft function
Autor:
John Jeffery, Paul C. Grimm, Rachel M. McKenna, Elzbieta Gospodarek, David N. Rush, Mary E. Russell, Peter Nickerson, Bin Liu, J Gough
Publikováno v:
Scopus-Elsevier
It has been reported previously that one-third of protocol renal biopsies in asymptomatic, biochemically stable renal transplant recipients in the first 6 mo show unsuspected subclinical graft rejection (both infiltrate and tubulitis) and that subcli
Autor:
John Jeffery, Rachel M. McKenna, David N. Rush, Paul C. Grimm, Mark L. Lipman, James Gough, Yingnian Shen
Publikováno v:
Transplantation. 66:1673-1681
Background. A significant percentage of biopsies from stable, well-functioning renal allografts have histologic findings consistent with acute rejection or borderline rejection. The implication of this finding is not yet fully understood. We analyzed
Publikováno v:
Current Opinion in Nephrology and Hypertension. 7:691-694
Early protocol biopsies of stable, well functioning renal allografts reveal a high prevalence of clinically unsuspected acute and chronic pathology. It is becoming increasingly apparent that these histopathological findings are both pathogenic and pr
Publikováno v:
Transplantation. 59:579-584
Immunosuppressive drugs used in clinical transplantation block cytokine mRNA transcription in vitro, but clinical rejection episodes are common. An understanding of what cytokine message is transcribed would be helpful in determining what contributes
Publikováno v:
Scopus-Elsevier
Publikováno v:
Nephron. 65:273-277
The production of TNF alpha by peripheral blood mononuclear cells (PBMC) was determined in 18 hemodialysis (HD) patients. Blood was taken from each patient before and after an HD treatment. Both pre- and post-HD PBMC produced significantly more TNF a