Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Rachel M. Holden"'
Autor:
Tristin E. Wilson, Rachel M. Holden
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 10 (2023)
Externí odkaz:
https://doaj.org/article/28565c5e859a481c96a539ddbc15cf97
Autor:
Jaya K. Sharma, Sono Khan, Tristin Wilson, Nathan Pilkey, Sanjana Kapuria, Angélique Roy, Michael A. Adams, Rachel M. Holden
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 10 (2023)
Background: Type 2 diabetes (T2D) and kidney disease are risk factors for vitamin D deficiency. Native forms of vitamin D have a lower risk of hypercalcemia than calcitriol, the active hormone. The enzyme responsible for activating native vitamin D i
Externí odkaz:
https://doaj.org/article/7328d1d8289341ab84de1c7e9a0ec054
Autor:
Natasha A. Jawa, Samuel A. Silver, Rachel M. Holden, Stephen H. Scott, Andrew G. Day, Patrick A. Norman, Benjamin Y. M. Kwan, David M. Maslove, John Muscedere, J. Gordon Boyd
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 10 (2023)
Background: Acute kidney injury (AKI) resulting in kidney replacement therapy is rising among critically ill adults. Long-term kidney replacement therapy and critical illness are independently linked to acute and prolonged cognitive impairment, and s
Externí odkaz:
https://doaj.org/article/23f17f7e323949cba5072152f7127dcf
Autor:
Mandy E. Turner, Tyler S. Rowsell, Christine A. White, Martin Kaufmann, Patrick A. Norman, Kathryn Neville, Martin Petkovich, Glenville Jones, Michael A. Adams, Rachel M. Holden
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-8 (2022)
Abstract Chronic kidney disease (CKD) results in calcitriol deficiency and altered vitamin D metabolism. The objective of this study was to assess the 24-hydroxylation-mediated metabolism of 25(OH)D3 and 1,25(OH)2D3 in a cross-sectional analysis of p
Externí odkaz:
https://doaj.org/article/0924dd975e214be3af3f9fb607ba07a1
Autor:
Nathan G. Pilkey, Olivia Novosel, Angélique Roy, Tristin E. Wilson, Jaya Sharma, Sono Khan, Sanjana Kapuria, Michael A. Adams, Rachel M. Holden
Publikováno v:
Nutrients, Vol 15, Iss 13, p 3072 (2023)
Vitamin D has been shown to have multiple pleiotropic effects beyond bone and mineral metabolism, with purported roles in cardiovascular disease, cancer, and host immunity. Vitamin D deficiency is common in patients with end-stage kidney disease (ESK
Externí odkaz:
https://doaj.org/article/5cf83826bad54cc78c86def264a6e453
Publikováno v:
Nutrients, Vol 14, Iss 18, p 3690 (2022)
Megalin is an endocytic receptor abundantly expressed in proximal tubular epithelial cells and other calciotropic extrarenal cells expressing vitamin D metabolizing enzymes, such as bone and parathyroid cells. The receptor functions in the uptake of
Externí odkaz:
https://doaj.org/article/3b4076bea6ef46b0a54c9c69c4df2612
Autor:
Bruno A. Svajger, Justin L. H. Riddoch, Cynthia M. Pruss, Kimberly J. Laverty, Emilie Ward, Rachel M. Holden, Michael A. Adams
Publikováno v:
Physiological Reports, Vol 8, Iss 21, Pp n/a-n/a (2020)
Abstract The mineral‐bone axis is tightly regulated and dependent on renal function. In chronic kidney disease (CKD) progressive loss of renal capacity disrupts this axis over‐time, with marked changes in circulating calcium, phosphate, PTH, and
Externí odkaz:
https://doaj.org/article/1fa52d5cf2e14faeb374b7a8a1fcdadc
Autor:
Rachel M. Holden, Reem A. Mustafa, R. Todd Alexander, Marisa Battistella, Micheli U. Bevilacqua, Greg Knoll, Fabrice Mac-Way, Martina Reslerova, Ron Wald, Philip D. Acott, Patrick Feltmate, Allan Grill, Kailash K. Jindal, Meena Karsanji, Bryce A. Kiberd, Sara Mahdavi, Kailee McCarron, Amber O. Molnar, Maury Pinsk, Celia Rodd, Steven D. Soroka, Amanda J. Vinson, Deborah Zimmerman, Catherine M. Clase
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 7 (2020)
Purpose of review: (1) To provide commentary on the 2017 update to the Kidney Disease Improving Global Outcomes (KDIGO) 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease-Mineral
Externí odkaz:
https://doaj.org/article/0db9d224d198451da9aacdeb976ef6c2
Autor:
Bruno A. Svajger, Cynthia M. Pruss, Kimberly J. Laverty, Jason G. E. Zelt, Glenville Jones, Martin Kaufmann, Martin Petkovich, Rachel M. Holden, Michael A. Adams
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 3, Pp n/a-n/a (2020)
Abstract Vitamin D receptor agonist (VDRA) therapy for PTH suppression is a mainstay for patients with severe CKD. Calcitriol (1,25‐(OH)2D3) is a former first‐line VDRA in CKD treatment. However, a consequence of its use in CKD is accelerated vas
Externí odkaz:
https://doaj.org/article/466b607f685f4fa0b0f553c185125b15
Publikováno v:
Canadian Journal of Kidney Health and Disease, Vol 7 (2020)
Background: Opiate and benzodiazepine use is associated with increased mortality and poorer transplant outcomes in patients with chronic kidney disease (CKD). Objective: To determine the predictors of opiate and benzodiazepine prescription in people
Externí odkaz:
https://doaj.org/article/5551d7dd24784004a31031c6eb466565