Výsledky vyhledávání - "Rachel M. Heinrich"

Akademický článek

Alu RNA Structural Features Modulate Immune Cell Activation and A-to-I Editing of Alu RNAs Is Diminished in Human Inflammatory Bowel Disease

Autor: Thomas M. Aune, John T. Tossberg, Rachel M. Heinrich, Krislyn P. Porter, Philip S. Crooke

Publikováno v: Frontiers in Immunology, Vol 13 (2022)

Alu retrotransposons belong to the class of short interspersed nuclear elements (SINEs). Alu RNA is abundant in cells and its repetitive structure forms double-stranded RNAs (dsRNA) that activate dsRNA sensors and trigger innate immune responses with

Externí odkaz: https://doaj.org/article/cba9c00726d949239c293db01b634cd7

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Reduced RNA adenosine-to-inosine editing in hippocampus vasculature associated with Alzheimer’s disease

Autor: Philip S, Crooke, John T, Tossberg, Rachel M, Heinrich, Krislyn P, Porter, Thomas M, Aune

Publikováno v: Brain Communications. 4

Alzheimer’s disease is the most common form of dementia and recent studies identify a type 1 interferon response in Alzheimer’s disease possibly driving neuro-inflammation and other Alzheimer’s disease pathologies. Loss of adenosine-to-inosine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff89f19071a0b3310dd97410da59b5bf
https://doi.org/10.1093/braincomms/fcac238

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Adenosine-to-Inosine RNA Editing of Alu Double-Stranded (ds)RNAs Is Markedly Decreased in Multiple Sclerosis and Unedited Alu dsRNAs Are Potent Activators of Proinflammatory Transcriptional Responses

Autor: John T. Tossberg, Rachel M. Heinrich, Thomas M. Aune, Philip S. Crooke, Virginia M. Farley

Publikováno v: The Journal of Immunology. 205:2606-2617

Sensors that detect dsRNA stimulate IFN responses as a defense against viral infection. IFN responses are also well documented in a variety of human autoimmune diseases, including relapsing–remitting multiple sclerosis (MS), in which increased IFN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ba313e62abd995c02bd0337519deb6af
https://doi.org/10.4049/jimmunol.2000384

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