Výsledky vyhledávání - "Rachel M. Hagen"

The oncogenic transcription factor ERG represses the transcription of the tumour suppressor gene PTEN in prostate cancer cells

Autor: Samantha L. Jumbe, Ian D. Wilson, Shavanthi Rajatileka, Michael Ladomery, Patricia Adamo, Sean Porazinski, Man‑Kim Cheung, Rachel M. Hagen

Publikováno v: Oncology Letters.

The oncogene ETS-related gene (ERG) encodes a transcription factor with roles in the regulation of haematopoiesis, angiogenesis, vasculogenesis, inflammation, migration and invasion. The ERG oncogene is activated in >50% of prostate cancer cases, gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49f33d1b183387c2e9a12d7777227ee0
https://doi.org/10.3892/ol.2017.6841

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Quantitative Analysis of ERG Expression and Its Splice Isoforms in Formalin-Fixed, Paraffin-Embedded Prostate Cancer Samples

Autor: Michael Ladomery, David Gillatt, Jonathan Aning, Raj Persad, Saima Karamat, Rachel M. Hagen, Jon Oxley, Anthony Rhodes, Patricia Adamo

Publikováno v: American Journal of Clinical Pathology. 142:533-540

Objectives: The proto-oncogene ETS-related gene ( ERG ) is consistently overexpressed in prostate cancer. Alternatively spliced isoforms of ERG have variable biological activities; inclusion of exon 11 (72 base pairs [bp]) is associated with aggressi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a71afd5e824e3d7919403117b4f851b6
https://doi.org/10.1309/ajcph88qhxarisup

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Adaptive Changes of the Insig1/SREBP1/SCD1 Set Point Help Adipose Tissue to Cope With Increased Storage Demands of Obesity

Publikováno v: Diabetes
RUNA. Repositorio da Consellería de Sanidade e Sergas
Servizo Galego de Saúde (SERGAS)
Diabetes, 2013, 62 (11), pp.3697-3708. ⟨10.2337/db12-1748⟩
Diabetes, American Diabetes Association, 2013, 62 (11), pp.3697-3708. ⟨10.2337/db12-1748⟩

The epidemic of obesity imposes unprecedented challenges on human adipose tissue (WAT) storage capacity that may benefit from adaptive mechanisms to maintain adipocyte functionality. Here, we demonstrate that changes in the regulatory feedback set po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f1b1c4a967559f56361109a5510ce68
http://europepmc.org/articles/PMC3806615

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A M-MLV reverse transcriptase with reduced RNaseH activity allows greater sensitivity of gene expression detection in formalin fixed and paraffin embedded prostate cancer samples

Autor: Rachel M. Hagen, Michael Ladomery, Anthony Rhodes, Jon Oxley

Publikováno v: Experimental and Molecular Pathology. 95:98-104

Formalin fixed and paraffin embedded (FFPE) human tissue collections are an invaluable resource for retrospective gene expression studies. However formalin fixation results in chemical modification of RNA and increased RNA degradation. This can affec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfede0ed245f90cb91060cb8b913b720
https://doi.org/10.1016/j.yexmp.2013.05.008

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Stearoyl-CoA Desaturase 1 Is a Key Determinant of Membrane Lipid Composition in 3T3-L1 Adipocytes

Autor: Rachel M. Hagen, Sergio Rodriguez-Cuenca, Maria Fuller, Antonio Vidal-Puig, Lauren S. Whyte

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0162047 (2016)

Stearoyl-CoA desaturase 1 (SCD1) is a lipogenic enzyme important for the regulation of membrane lipid homeostasis; dysregulation likely contributes to obesity associated metabolic disturbances. SCD1 catalyses the Δ9 desaturation of 12-19 carbon satu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81bcbcf204287e190689da770b12b24
http://europepmc.org/articles/PMC5025088

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Role of splice variants in the metastatic progression of prostate cancer

Autor: Michael Ladomery, Rachel M. Hagen

Publikováno v: Biochemical Society Transactions. 40:870-874

AS (alternative splicing) and its role in disease, especially cancer, has come to forefront in research over the last few years. Alterations in the ratio of splice variants have been widely observed in cancer. Splice variants of cancer-associated gen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fd6c92975e6362d58a8102e1c7151cc
https://doi.org/10.1042/bst20120026

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No association between polymorphisms in the INSIG1 gene and the risk of type 2 diabetes and related traits

Autor: Ruth J. F. Loos, Aline Meirhaeghe, Nicholas J. Wareham, Cyrus Cooper, Luis Moreno, Jian'an Luan, Magdalena Szopa, Antonio Vidal-Puig, Marcela González-Gross, Rachel M. Hagen, Philippe Amouyel

Publikováno v: The American Journal of Clinical Nutrition. 92:252-257

BACKGROUND: The insulin-induced gene 1 (INSIG1) encodes a protein that blocks proteolytic activation of sterol regulatory element binding proteins, which are transcription factors that activate genes that regulate cholesterol, fatty acid, and glucose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f83ba0bc727c470a116a2af6a0973fe
https://doi.org/10.3945/ajcn.2010.29422

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Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence

Autor: Rachel M, Hagen, Patricia, Adamo, Saima, Karamat, Jon, Oxley, Jonathan J, Aning, David, Gillatt, Raj, Persad, Michael R, Ladomery, Anthony, Rhodes

Publikováno v: American journal of clinical pathology. 142(4)

The proto-oncogene ETS-related gene (ERG) is consistently overexpressed in prostate cancer. Alternatively spliced isoforms of ERG have variable biological activities; inclusion of exon 11 (72 base pairs [bp]) is associated with aggressiveness and pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::85d34177d46e9cc02334af91851e4069
https://pubmed.ncbi.nlm.nih.gov/25239421

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Conjugated linoleate reduces prostate cancer viability whereas the effects of oleate and stearate are cell line-dependent

Autor: Rachel M, Hagen, Anthony, Rhodes, Michael R, Ladomery

Publikováno v: Anticancer research. 33(10)

In this study, responses to fatty acid treatments in commonly used prostate cancer cell culture models and variability of gene expression between them were determined.PC3, DU145, LNCaP, VCaP and PNT2 cells were treated with 100 μM of either oleate,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cda3ef47aad70a1b3e6757c3a9603107
https://pubmed.ncbi.nlm.nih.gov/24123008

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Epigallocatechin-3-gallate promotes apoptosis and expression of the caspase 9a splice variant in PC3 prostate cancer cells

Autor: Christopher P. Mintoff, Elizabeth Bowler, Michael Ladomery, Rachel M. Hagen, H. Ruth Morse, Veronica Sanda Chedea

Publikováno v: International journal of oncology. 43(1)

Growing evidence suggests that the flavonoid epigallocatechin-3-gallate (EGCG), notably abundant in green tea, has health-promoting properties. We examined the effect of EGCG on cell survival and apoptosis in the prostate cancer cell line PC3. Cell s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6ad6c8b838b1b73cba32bfd85cfe67f
https://pubmed.ncbi.nlm.nih.gov/23615977

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