Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Rachel M. Brooker"'
Autor:
Jack J. Kinsora, Jared B.J. Milbank, Rachel M. Brooker, Christopher S. Knauer, Kenneth S. Kilgore, Cleo J. C. Connolly, John A. Wendt, Corinne E. Augelli-Szafran, Koji Yamagata, Susan E. Bove, Mickelson John, Paul Galatsis, Roy D. Schwarz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6525-6528
We describe three novel regioisomeric series of aryl naphthyridine analogs, which are potent antagonists of the Class III GPCR mGlu5 receptor. The synthesis and in vitro and in vivo pharmacological activities of these analogs are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d99bb1ead705ce7ec70a6e5c13920183
https://doi.org/10.1016/j.bmcl.2007.09.083
https://doi.org/10.1016/j.bmcl.2007.09.083
Autor:
Roberto E. Guzman, Kenneth S. Kilgore, Susan L. Calcaterra, D.J Schrier, Susan E. Bove, C.M Huber, Rachel M. Brooker, P.L. Juneau
Publikováno v:
Osteoarthritis and Cartilage. 11:821-830
Objective: To describe an in vivo model in the rat in which change in weight distribution is used as a measure of disease progression and efficacy of acetaminophen and two nonsteroidal anti-inflammatory drugs (NSAIDs) in a model of monosodium iodoace
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd130229a0200e8c187af573c05583e5
https://doi.org/10.1016/s1063-4584(03)00163-8
https://doi.org/10.1016/s1063-4584(03)00163-8
Autor:
Susan E. Bove, John A. Wendt, Corinne E. Augelli-Szafran, Kenneth S. Kilgore, Christopher S. Knauer, Susan D. Deeter, Jack J. Kinsora, Roy D. Schwarz, Rachel M. Brooker
Publikováno v:
ChemInform. 39
A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::821f1825129e92c907f5ec5f4d237022
https://doi.org/10.1002/chin.200805156
https://doi.org/10.1002/chin.200805156
Autor:
Susan E. Bove, Christopher S. Knauer, Roy D. Schwarz, Rachel M. Brooker, John A. Wendt, Corinne E. Augelli-Szafran, Jack J. Kinsora, Susan D. Deeter, Kenneth S. Kilgore
Publikováno v:
Bioorganicmedicinal chemistry letters. 17(19)
A novel series of potent 2-aryl pyrido[2,3-d]pyrimidine mGlu5 receptor antagonists are described. The synthesis and pharmacological activities of these analogs are discussed.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdfcd9f8f8c58ec833be687d17fff294
https://pubmed.ncbi.nlm.nih.gov/17723296
https://pubmed.ncbi.nlm.nih.gov/17723296
Autor:
Susan E. Bove, Kenneth S. Kilgore, K.D. Laemont, J.R. Connor, Brian Sanchez, Megan Osborn, P.L. Juneau, K.E. Hook, Roberto E. Guzman, Rachel M. Brooker
Publikováno v:
Osteoarthritis and Cartilage. (10):1041-1048
SummaryObjectiveIn the present study, we sought to develop/characterize the pain profile of a rat model of surgically induced osteoarthritis (OA).MethodsOA was surgically induced in male Lewis rats (200–225g) by transection of the medial collateral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134badb745b3f083ad4fde51e52de40b