Comparing cervical cerclage, pessary and vaginal progesterone for prevention of preterm birth in women with a short cervix (SuPPoRT): A multicentre randomised controlled trial.

Autor: Natasha L Hezelgrave, Natalie Suff, Paul Seed, Vicky Robinson, Jenny Carter, Helena Watson, Alexandra Ridout, Anna L David, Susana Pereira, Fatemeh Hoveyda, Joanna Girling, Latha Vinayakarao, Rachel M Tribe, Andrew H Shennan, SuPPoRT Collaborating Team

Publikováno v: PLoS Medicine, Vol 21, Iss 7, p e1004427 (2024)

BackgroundCervical cerclage, cervical pessary, and vaginal progesterone have each been shown to reduce preterm birth (PTB) in high-risk women, but to our knowledge, there has been no randomised comparison of the 3 interventions. The SuPPoRT "Stitch,

Externí odkaz: https://doaj.org/article/c0d98c5b5439498fa6fa23a3d243161d

The PROMISES study: a mixed methods approach to explore the acceptability of salivary progesterone testing for preterm birth risk among pregnant women and trained frontline healthcare workers in rural India

Autor: Paul T Seed, Vikram Singh, Sergio A Silverio, Rachel M Tribe, Danielle Ashworth, Pankhuri Sharma, Simi Khan, Nishtha Kathuria, Priyanka Garg, Mohan Ghule, V B Shivkumar, Atul Tayade, Sunil Mehra, Poonam V Shivkumar, Ritu Dargan, Archana Sarkar, Lalita Sengupta

Publikováno v: BMJ Open, Vol 11, Iss 1 (2021)

Introduction India has an overall neonatal mortality rate of 28/1000 live births, with higher rates in rural India. Approximately 3.5 million pregnancies in India are affected by preterm birth (PTB) annually and contribute to approximately a quarter

Externí odkaz: https://doaj.org/article/dc859b628aa14e89961524c8008ee871

Pregnancy cohorts and biobanking in sub-Saharan Africa: a systematic review

Autor: Sanjeev Krishna, Andrew Shennan, Helena Boene, Marianne Vidler, Laura A Magee, Esperanca Sevene, Peter von Dadelszen, Eusébio Macete, Anifa Vala, Salésio Macuacua, Sónia Maculuve, Jeffrey Bone, Beth A Payne, Jane Sandall, Veronique Filippi, Lucilla Poston, Kate Bramham, Lucy Chappell, Melisa Martinez-Alvarez, Geoffrey Omuse, Guy Whitley, Hannah Blencowe, Sean Beevers, Rachel Craik, Marleen Temmerman, Jeffrey N Bone, Kelly Pickerill, Mai-Lei Woo Kinshella, William Stones, Angela Koech Etyang, Anna Roca, Donna Russell, Rachel M Tribe, Umberto D’Alessandro, Hawanatu Jah, Ofordile Oguchukwu, Andrew Prentice, Brahima Diallo, Adbul Sesey, Kodou Lette, Alpha Bah, Chilel Sanyang, Peris Musitia, Mary Amondi, David Chege, Patricia Okiro, Sikolia Wanyonyi, Paulo Chin, Corssino Tchavana, Lazaro Quimice, Inacio Mandomando, Carla Carillho, Meriel Flint-O’Kane, Amber Strang, Marina Daniele, Tatenda Makanga, Liberty Makacha, Yolisa Dube, Newton Nyapwere, Rachel Tribe, Sophie Moore, Tatiana Salisbury, Ben Barratt, Aris Papageorgiou, Alison Noble, Joy Lawn, Matt Silver, Matthew Chico, Judith Cartwright, Jing (Larry) Li, Mai-Lei (Maggie) Woo Kinshella, Domena Tu, Warancha Tumtaweetikul, Marie-Laure Volvert

Publikováno v: BMJ Global Health, Vol 5, Iss 11 (2020)

Background Technological advances and high throughput biological assays can facilitate discovery science in biobanks from population cohorts, including pregnant women. Biological pathways associated with health outcomes differ depending on geography,

Externí odkaz: https://doaj.org/article/c62b63165c6b4c26a0ac112213dffda0

The interaction between protein kinase A and progesterone on basal and inflammation-induced myometrial oxytocin receptor expression.

Autor: Angela Yulia, Alice J Varley, Natasha Singh, Kaiyu Lei, Rachel M Tribe, Mark R Johnson

Publikováno v: PLoS ONE, Vol 15, Iss 12, p e0239937 (2020)

Our previous work has shown myometrial PKA activity declines in term and twin-preterm labour in association with an increase in the expression of the oxytocin receptor (OTR). Here we investigate the action of cAMP/PKA in basal conditions, with the ad

Externí odkaz: https://doaj.org/article/fd00cc7d88f445c8b7a58e2b79f0bc8b

Computational modeling reveals key contributions of KCNQ and hERG currents to the malleability of uterine action potentials underpinning labor.

Autor: Wing-Chiu Tong, Rachel M Tribe, Roger Smith, Michael J Taggart

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e114034 (2014)

The electrical excitability of uterine smooth muscle cells is a key determinant of the contraction of the organ during labor and is manifested by spontaneous, periodic action potentials (APs). Near the end of term, APs vary in shape and size reflecti

Externí odkaz: https://doaj.org/article/149ad26228ea44b3916cf022f06df46a