Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Rachel M McLoughlin"'
Autor:
Edward JA Douglas, Nathanael Palk, Tarcisio Brignoli, Dina Altwiley, Marcia Boura, Maisem Laabei, Mario Recker, Gordon YC Cheung, Ryan Liu, Roger C Hsieh, Michael Otto, Eoin O'Brien, Rachel M McLoughlin, Ruth C Massey
Publikováno v:
eLife, Vol 12 (2023)
The bloodstream represents a hostile environment that bacteria must overcome to cause bacteraemia. To understand how the major human pathogen Staphylococcus aureus manages this we have utilised a functional genomics approach to identify a number of n
Externí odkaz:
https://doaj.org/article/cdc03cf522bf4fe480f332e52fd5fd2c
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010647 (2022)
Staphylococcus aureus persistently colonises the anterior nares of a significant proportion of the healthy population, however the local immune response elicited during S. aureus nasal colonisation remains ill-defined. Local activation of IL-17/IL-22
Externí odkaz:
https://doaj.org/article/f7b71f701b394d159a48d2c861c49246
Publikováno v:
PLoS Pathogens, Vol 15, Iss 4, p e1007713 (2019)
Staphylococcus aureus expresses a number of cell wall-anchored proteins that mediate adhesion and invasion of host cells and tissues and promote immune evasion, consequently contributing to the virulence of this organism. The cell wall-anchored prote
Externí odkaz:
https://doaj.org/article/10c1944b0bb743adbd57c8f6ef6f6f06
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006452 (2017)
The secretion of proteins that damage host tissue is well established as integral to the infectious processes of many bacterial pathogens. However, recent advances in our understanding of the activity of toxins suggest that the attributes we have ass
Externí odkaz:
https://doaj.org/article/fcf54517baa54b51af7d773d055df2ce
Autor:
Aisling F Brown, Alison G Murphy, Stephen J Lalor, John M Leech, Kate M O'Keeffe, Micheál Mac Aogáin, Dara P O'Halloran, Keenan A Lacey, Mehri Tavakol, Claire H Hearnden, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Jérôme P Fennell, Willem J van Wamel, Timothy J Foster, Joan A Geoghegan, Ed C Lavelle, Thomas R Rogers, Rachel M McLoughlin
Publikováno v:
PLoS Pathogens, Vol 11, Iss 11, p e1005226 (2015)
Mechanisms of protective immunity to Staphylococcus aureus infection in humans remain elusive. While the importance of cellular immunity has been shown in mice, T cell responses in humans have not been characterised. Using a murine model of recurrent
Externí odkaz:
https://doaj.org/article/6832261a8fdf4af4abe77367d6c1163a
Autor:
Pádraig J Ross, Caroline E Sutton, Sarah Higgins, Aideen C Allen, Kevin Walsh, Alicja Misiak, Ed C Lavelle, Rachel M McLoughlin, Kingston H G Mills
Publikováno v:
PLoS Pathogens, Vol 9, Iss 4, p e1003264 (2013)
Whooping cough caused by Bordetella pertussis is a re-emerging infectious disease despite the introduction of safer acellular pertussis vaccines (Pa). One explanation for this is that Pa are less protective than the more reactogenic whole cell pertus
Externí odkaz:
https://doaj.org/article/d7bf61e475f04022b523038a184dceda
Autor:
Michelle E Mulcahy, Joan A Geoghegan, Ian R Monk, Kate M O'Keeffe, Evelyn J Walsh, Timothy J Foster, Rachel M McLoughlin
Publikováno v:
PLoS Pathogens, Vol 8, Iss 12, p e1003092 (2012)
Staphylococcus aureus asymptomatically colonises the anterior nares, but the host and bacterial factors that facilitate colonisation remain incompletely understood. The S. aureus surface protein ClfB has been shown to mediate adherence to squamous ep
Externí odkaz:
https://doaj.org/article/885fbdf6d1ff45dbb4315e409caa645a
Autor:
Edel A McNeela, Aine Burke, Daniel R Neill, Cathy Baxter, Vitor E Fernandes, Daniela Ferreira, Sarah Smeaton, Rana El-Rachkidy, Rachel M McLoughlin, Andres Mori, Barry Moran, Katherine A Fitzgerald, Jurg Tschopp, Virginie Pétrilli, Peter W Andrew, Aras Kadioglu, Ed C Lavelle
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001191 (2010)
Pneumolysin (PLY) is a key Streptococcus pneumoniae virulence factor and potential candidate for inclusion in pneumococcal subunit vaccines. Dendritic cells (DC) play a key role in the initiation and instruction of adaptive immunity, but the effects
Externí odkaz:
https://doaj.org/article/e10145540ddd48788b803169ff38aeef
Publikováno v:
PLoS ONE, Vol 5, Iss 10, p e13227 (2010)
Zwitterionic polysaccharide (ZPS) components of the bacterial cell envelope have been shown to exert a major histocompatibility complex (MHC) II-dependent activation of CD4+ T cells, which in turn can modulate the outcome and progression of infection
Externí odkaz:
https://doaj.org/article/715f13f42def481d8af6f4fa74229ef9
Autor:
Marcin Baran, Claudia Feriotti, Aoife McGinley, Simon R. Carlile, Zhaozhao Jiang, Ricardo Calderon-Gonzalez, Amy Dumigan, Joana Sá-Pessoa, Caroline E. Sutton, Jay Kearney, Rachel M. McLoughlin, Kingston H.G. Mills, Katherine A. Fitzgerald, Jose A. Bengeochea, Andrew G. Bowie
Publikováno v:
Baran, M, Feriotti, C, McGinley, A, Carlile, S R, Jiang, Z, Calderon-Gonzalez, R, Dumigan, A, Sá-Pessoa, J, Sutton, C E, Kearney, J, McLoughlin, R M, Mills, K H G, Fitzgerald, K A, Bengeochea, J A & Bowie, A G 2023, ' PYHIN protein IFI207 regulates cytokine transcription and IRF7 and contributes to the establishment of K. pneumoniae infection ', Cell Reports, vol. 42, no. 4, 112341 . https://doi.org/10.1016/j.celrep.2023.112341
PYHIN proteins AIM2 and IFI204 sense pathogen DNA, while other PYHINs have been shown to regulate host gene expression through as-yet unclear mechanisms. We characterize mouse PYHIN IFI207, which we find is not involved in DNA sensing but rather is r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1330d084367c0ce1690532e485604edb
https://pure.qub.ac.uk/en/publications/ce84d15e-f639-46cb-9993-123254870560
https://pure.qub.ac.uk/en/publications/ce84d15e-f639-46cb-9993-123254870560
