Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Rachel M Johnson"'
Autor:
Ilhan Özgen-Xian, Sergi Molins, Rachel M. Johnson, Zexuan Xu, Dipankar Dwivedi, Ralf Loritz, Utkarsh Mital, Craig Ulrich, Qina Yan, Carl I. Steefel
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract We computationally explore the relationship between surface–subsurface exchange and hydrological response in a headwater-dominated high elevation, mountainous catchment in East River Watershed, Colorado, USA. In order to isolate the effect
Externí odkaz:
https://doaj.org/article/2d8dd62d26eb46bb91b9cb580e82664c
Autor:
Laura Perlaza-Jiménez, Kher-Shing Tan, Sarah J. Piper, Rachel M. Johnson, Rebecca S. Bamert, Christopher J. Stubenrauch, Alexander Wright, David Lupton, Trevor Lithgow, Matthew J. Belousoff
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 4 (2022)
ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a bacterial pathogen that presents great health concerns. Treatment requires the use of last-line antibiotics, such as members of the oxazolidinone family, of which linezolid is the first
Externí odkaz:
https://doaj.org/article/2c65c5d7458f48f4833754bb53033c4f
Autor:
David J. Wright, Katie J. Simmons, Rachel M. Johnson, David J. Beech, Stephen P. Muench, Robin S. Bon
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Wright et al. report the first structure of a human TRPC1/4/5 channel in complex with a xanthine-based TRPC5 inhibitor Pico145. They find that Pico145 binds to a conserved lipid binding site of TRPC5, where it displaces a phospholipid. This study pro
Externí odkaz:
https://doaj.org/article/a4fe404129504c4c9fa1e7487c3b639e
Autor:
M. Arif M. Jamali, Chai C. Gopalasingam, Rachel M. Johnson, Takehiko Tosha, Kazumasa Muramoto, Stephen P. Muench, Svetlana V. Antonyuk, Yoshitsugu Shiro, Samar S. Hasnain
Publikováno v:
IUCrJ, Vol 7, Iss 3, Pp 404-415 (2020)
Neisseria meningitidis is carried by nearly a billion humans, causing developmental impairment and over 100 000 deaths a year. A quinol-dependent nitric oxide reductase (qNOR) plays a critical role in the survival of the bacterium in the human host.
Externí odkaz:
https://doaj.org/article/41d352f6daba48bd9434493987017ecb
Publikováno v:
ACS Catalysis. 13:1899-1905
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3fcb19f5e1af90bc43ef3856b6c17a4b
https://doi.org/10.1021/acscatal.2c05439
https://doi.org/10.1021/acscatal.2c05439
Autor:
Martin J. McPhillie, Ying Zhou, Mark R. Hickman, James A. Gordon, Christopher R. Weber, Qigui Li, Patty J. Lee, Kangsa Amporndanai, Rachel M. Johnson, Heather Darby, Stuart Woods, Zhu-hong Li, Richard S. Priestley, Kurt D. Ristroph, Scott B. Biering, Kamal El Bissati, Seungmin Hwang, Farida Esaa Hakim, Sarah M. Dovgin, Joseph D. Lykins, Lucy Roberts, Kerrie Hargrave, Hua Cong, Anthony P. Sinai, Stephen P. Muench, Jitender P. Dubey, Robert K. Prud'homme, Hernan A. Lorenzi, Giancarlo A. Biagini, Silvia N. Moreno, Craig W. Roberts, Svetlana V. Antonyuk, Colin W. G. Fishwick, Rima McLeod
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 10 (2020)
Apicomplexan infections cause substantial morbidity and mortality, worldwide. New, improved therapies are needed. Herein, we create a next generation anti-apicomplexan lead compound, JAG21, a tetrahydroquinolone, with increased sp3-character to impro
Externí odkaz:
https://doaj.org/article/2c4f99fc24ed49b8a965b629b176459d
Autor:
Bethan A. Cole, Rachel M. Johnson, Hattapark Dejakaisaya, Nadia Pilati, Colin W.G. Fishwick, Stephen P. Muench, Jonathan D. Lippiat
Publikováno v:
iScience, Vol 23, Iss 5, Pp - (2020)
Summary: Drug-resistant epileptic encephalopathies of infancy have been associated with KCNT1 gain-of-function mutations, which increase the activity of KNa1.1 sodium-activated potassium channels. Pharmacological inhibition of hyperactive KNa1.1 chan
Externí odkaz:
https://doaj.org/article/f3264e823a434571aabe565029cbfe0e
Autor:
Kangsa Amporndanai, Rachel M. Johnson, Paul M. O'Neill, Colin W. G. Fishwick, Alexander H. Jamson, Shaun Rawson, Stephen P. Muench, S. Samar Hasnain, Svetlana V. Antonyuk
Publikováno v:
IUCrJ, Vol 5, Iss 2, Pp 200-210 (2018)
Cytochrome bc1, a dimeric multi-subunit electron-transport protein embedded in the inner mitochondrial membrane, is a major drug target for the treatment and prevention of malaria and toxoplasmosis. Structural studies of cytochrome bc1 from mammalian
Externí odkaz:
https://doaj.org/article/a9927769951f4f6387d594d9fbff2534
Autor:
Brian P Cary, Xin Zhang, Jianjun Cao, Rachel M Johnson, Sarah J Piper, Elliot J Gerrard, Denise Wootten, Patrick M Sexton
Publikováno v:
Endocrine Reviews. 44:492-517
G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large extracellular domains (ECDs) and respond to long polypeptide hormones.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ad7769da2b7982ca599f69f23947fcc
https://doi.org/10.1210/endrev/bnac033
https://doi.org/10.1210/endrev/bnac033
Publikováno v:
Chemical Reviews. 122:13989-14017
Membrane proteins are highly diverse in both structure and function and can, therefore, present different challenges for structure determination. They are biologically important for cells and organisms as gatekeepers for information and molecule tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b31da1dd6dbea666a13ff7465a4aa0b7
https://doi.org/10.1021/acs.chemrev.1c00837
https://doi.org/10.1021/acs.chemrev.1c00837