Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Rachel L. Tennyson"'
Publikováno v:
ChemBioChem. 21:2435-2439
We report fusion proteins designed to bind spatially distinct epitopes on the extracellular portion of HER2, a breast cancer biomarker and established therapeutic target, and recruit IgG (either anti-His6 or serum IgG) to the cell surface. When the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b5347103cdc086077e41df0e679e42b
https://doi.org/10.1002/cbic.202000083
https://doi.org/10.1002/cbic.202000083
Publikováno v:
ACS infectious diseases. 5(4)
Drugs that block HIV-1 entry are relatively limited. Enfuvirtide is a 36-residue synthetic peptide that targets gp41 and blocks viral fusion. However, Enfuvirtide-resistant HIV has been reported, and this peptide drug requires daily injection. Previo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2a3899610e68b6098ced0b35e85ec0
https://pubmed.ncbi.nlm.nih.gov/30811933
https://pubmed.ncbi.nlm.nih.gov/30811933
Autor:
Rachel L. Tennyson, Susanne N. Walker, Brian R. McNaughton, Reuben S. Harris, Terumasa Ikeda, Alan J. Kennan
Publikováno v:
ChemBioChem. 17:1945-1950
The size, functional group diversity and three-dimensional structure of proteins often allow these biomolecules to bind disease-relevant structures that challenge or evade small-molecule discovery. Additionally, folded proteins are often much more st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74dd9e5dd5ed160dbeca579405c4831f
https://doi.org/10.1002/cbic.201600329
https://doi.org/10.1002/cbic.201600329
Publikováno v:
Bioorganicmedicinal chemistry. 26(6)
Many therapeutically-relevant protein-protein interactions (PPIs) have been reported that feature a helix and helix-binding cleft at the interface. Given this, different approaches to disrupting such PPIs have been developed. While short peptides (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546a720629c12702ffcb6e47cd838edb
https://pubmed.ncbi.nlm.nih.gov/28811070
https://pubmed.ncbi.nlm.nih.gov/28811070
Publikováno v:
ChemBioChem; Sep2020, Vol. 21 Issue 17, p2435-2439, 5p
Autor:
Tennyson, Rachel L., Walker, Susanne N., Ikeda, Terumasa, Harris, Reuben S., Kennan, Alan J., McNaughton, Brian R.
Publikováno v:
ChemBioChem; 10/17/2016, Vol. 17 Issue 20, p1945-1950, 6p
Autor:
Walker, Susanne N., Tennyson, Rachel L., Chapman, Alex M., Kennan, Alan J., McNaughton, Brian R.
Publikováno v:
ChemBioChem; Jan2015, Vol. 16 Issue 2, p219-222, 4p