Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Rachel L. Mendes"'
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Supplementary Data, Table S1, S3, S6, S8, S10-S13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b265e4961eac4720f5366a19b7c1c2
https://doi.org/10.1158/2159-8290.22535216
https://doi.org/10.1158/2159-8290.22535216
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Table S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a1bf13695abb378067b126ed241cfc8
https://doi.org/10.1158/2159-8290.22535225
https://doi.org/10.1158/2159-8290.22535225
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Table S9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6645653db29839d8ab0c10bd031b1919
https://doi.org/10.1158/2159-8290.22535219.v1
https://doi.org/10.1158/2159-8290.22535219.v1
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
KRAS is the most frequently mutated driver of pancreatic, colorectal, and non–small cell lung cancers. Direct KRAS blockade has proved challenging, and inhibition of a key downstream effector pathway, the RAF–MEK–ERK cascade, has shown limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4207250379f0cc7e1fcd4e873b0d65cb
https://doi.org/10.1158/2159-8290.c.6547790.v1
https://doi.org/10.1158/2159-8290.c.6547790.v1
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Table S4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52ee8f4a903b5dfb360e7672dae7df68
https://doi.org/10.1158/2159-8290.22535228
https://doi.org/10.1158/2159-8290.22535228
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Table S7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eadd77081de78982fe6c9ec077d4bc2
https://doi.org/10.1158/2159-8290.22535222
https://doi.org/10.1158/2159-8290.22535222
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Table S2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7c2a1bf3db0c78a162268cba92d011
https://doi.org/10.1158/2159-8290.22535231.v1
https://doi.org/10.1158/2159-8290.22535231.v1
Autor:
Norbert Kraut, Darryl B. McConnell, Mark Pearson, Timothy P. Heffernan, Mark Petronczki, Jurgen Moll, Rachel L. Mendes, Jonathan C. O'Connell, Christopher P. Vellano, Simone Lieb, Katharina Schipany, Franziska Schachinger, Nikolai Pototschnig, Jark Böttcher, Jessica L. Teh, Szu-Chin Fu, Andreas Zoephel, Tobias Wunberg, Christiane Kofink, Thomas Gerstberger, Peter Ettmayer, Dana-Adriana Botesteanu, Klaus Rumpel, Heribert Arnhof, Francesca Trapani, Dirk Kessler, Michael P. Sanderson, Joseph R. Marszalek, Daniel Gerlach, Fabio Savarese, Juergen Ramharter, Michael Gmachl, Marco H. Hofmann
Supplementary Figures S1-S5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d96dfb43e0dbbd26e81b12152a9d88c
https://doi.org/10.1158/2159-8290.22535234
https://doi.org/10.1158/2159-8290.22535234
Autor:
Reiner Meyer, Heribert Arnhof, Daniela Haering, Rachel L Mendes, David J. Richard, Irene Weiner, Norbert Kraut, Wolfgang Hela, Christian Salamon, Klaus Rumpel, Gerd Bader, Michael Gmachl, Andreas Dr. Zöphel, Renate Schnitzer, Peter Ettmayer, Jark Böttcher, Matthew D Kennedy, Juergen Ramharter, Michael P. Sanderson, Darryl B. McConnell, Nikolai Pototschnig, Dirk Kessler, Silvia Munico-Martinez, Tobias Wunberg, Marco H. Hofmann, Katja Hauer, Thomas Gerstberger, Lyne Lamarre, Patrick Werni, Christiane Kofink, Jonathan O’Connell, Bernhard Wolkerstorfer
Publikováno v:
Journal of medicinal chemistry. 64(10)
KRAS, the most common oncogenic driver in human cancers, is controlled and signals primarily through protein-protein interactions (PPIs). The interaction between KRAS and SOS1, crucial for the activation of KRAS, is a typical, challenging PPI with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1a72ff255807ec04be01fa8780adf61
https://pubmed.ncbi.nlm.nih.gov/33719426
https://pubmed.ncbi.nlm.nih.gov/33719426
Autor:
Szu-Chin Fu, Norbert Kraut, Rachel L Mendes, Marco H. Hofmann, Michael Gmachl, Peter Ettmayer, Katharina Schipany, Juergen Ramharter, Joseph R. Marszalek, Michael P. Sanderson, Tobias Wunberg, Fabio Savarese, Mark Petronczki, Timothy P. Heffernan, Thomas Gerstberger, Jark Böttcher, Mark Pearson, Dana-Adriana Botesteanu, Daniel Gerlach, Dirk Kessler, Franziska Schachinger, Klaus Rumpel, Jessica Teh, Jonathan O’Connell, Christiane Kofink, Heribert Arnhof, Simone Lieb, Jürgen Moll, Christopher P. Vellano, Nikolai Pototschnig, Andreas Zoephel, Darryl B. McConnell, Francesca Trapani
Publikováno v:
Cancer discovery. 11(1)
KRAS is the most frequently mutated driver of pancreatic, colorectal, and non–small cell lung cancers. Direct KRAS blockade has proved challenging, and inhibition of a key downstream effector pathway, the RAF–MEK–ERK cascade, has shown limited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbecb23494b6ef4a8ee31ed4191d443e
https://pubmed.ncbi.nlm.nih.gov/34003780
https://pubmed.ncbi.nlm.nih.gov/34003780