Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Rachel L. French"'
Autor:
Anupama K Puppala, Jennifer Castillo Suchkou, Rachel L French, Kaitlyn A Kiernan, Miljan Simonović
Publikováno v:
Nucleic Acids Research. 51:4012-4026
O-Phosphoseryl-tRNASec selenium transferase (SepSecS) catalyzes the terminal step of selenocysteine (Sec) synthesis in archaea and eukaryotes. How the Sec synthetic machinery recognizes and discriminates tRNASec from the tRNA pool is essential to the
Specific RNA interactions promote TDP‐43 multivalent phase separation and maintain liquid properties
Autor:
Zachary R. Grese, Yuna M. Ayala, Timothy M. Miller, Alliny Cs Bastos, Lohany D Mamede, Rachel L. French
Publikováno v:
EMBO Rep
TDP-43 is an RNA-binding protein that forms ribonucleoprotein condensates via liquid-liquid phase separation (LLPS) and regulates gene expression through specific RNA interactions. Loss of TDP-43 protein homeostasis and dysfunction are tied to neurod
Autor:
Jessica N. Patterson, Sara K. Pittman, Yuna M. Ayala, Jan Bieschke, Paul T. Kotzbauer, Mohamed Salman Kaleelurrrahuman, William J. Buscher, Dhruva Dhavale, Conrad C. Weihl, Yuanzi Sun, Albert A. Davis, Jiang Zhu, Rachel L. French
Background: Neuronal uptake and subsequent spread of proteopathic seeds, such as αS (alpha-synuclein), tau, and TDP-43, contribute to neurodegeneration and disease progression. The cellular machinery necessary for this process is poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed2c9ab2ae6c2ddebc252e0e57da8e8
https://doi.org/10.1101/2021.07.12.452081
https://doi.org/10.1101/2021.07.12.452081
Autor:
Praveen Subramanian, Yuna M. Ayala, Binyan Lin, Rachel L. French, Wen Li, Eileen H. Bigio, Catherine R. Knoverek, Ashley N. Reeb, Erin E. Fey
Publikováno v:
Journal of Biological Chemistry. 292:5089-5100
TAR DNA-binding protein (TDP-43) is a highly conserved and essential DNA- and RNA-binding protein that controls gene expression through RNA processing, in particular, regulation of splicing. Intracellular aggregation of TDP-43 is a hallmark of amyotr
Autor:
Zachary R. Grese, Yuna M. Ayala, Aligireddy H, Ashley N. Reeb, Jan Bieschke, Paul T. Kotzbauer, Niraja Kedia, Dhruva Dhavale, Rachel L. French
Aggregates of the RNA binding protein TDP-43 are a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which are neurodegenerative disorders with overlapping clinical, genetic and pathological features. Mutations in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21dbc51948af0a5435a6006b09ca55b7
https://doi.org/10.1101/499343
https://doi.org/10.1101/499343
Autor:
Yuna M. Ayala, Zachary R. Grese, Ashley N. Reeb, Niraja Kedia, Jan Bieschke, Paul T. Kotzbauer, Rachel L. French, Dhruva Dhavale, Himani Aligireddy
Publikováno v:
The Journal of biological chemistry. 294(17)
Aggregates of the RNA-binding protein TDP-43 (TAR DNA-binding protein) are a hallmark of the overlapping neurodegenerative disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. The process of TDP-43 aggregation remains poorly und
Autor:
Rachel L. French, Yuchen Liu, Marja Lähde, Henna Tyynismaa, Emil Ylikallio, Anni Laari, Leena Valanne, Tarja Linnankivi, Anders Paetau, Anna-Elina Lehesjoki, Taru Hilander, Miljan Simonović, Pirjo Isohanni, Dorota Muth-Pawlak, Anna-Kaisa Anttonen, Tuula Lönnqvist, Dieter Söll, Helena Pihko, Anu Suomalainen, Garry L. Corthals, Mirja Somer
Publikováno v:
Neurology. 85(4):306-315
Objective: We aimed to decipher the molecular genetic basis of disease in a cohort of children with a uniform clinical presentation of neonatal irritability, spastic or dystonic quadriplegia, virtually absent psychomotor development, axonal neuropath
Autor:
Sriram Subramaniam, Miljan Simonović, Rachel L. French, Doreen Matthies, Ulrich Baxa, Anupama K. Puppala
Publikováno v:
Scientific Reports
Selenocysteine synthase (SepSecS) catalyzes the terminal reaction of selenocysteine, and is vital for human selenoproteome integrity. Autosomal recessive inheritance of mutations in SepSecS–Ala239Thr, Thr325Ser, Tyr334Cys and Tyr429*–induced seve
Publikováno v:
The Journal of biological chemistry. 289(42)
Selenocysteine (Sec), the 21(st) amino acid, is synthesized from a serine precursor in a series of reactions that require selenocysteine tRNA (tRNA(Sec)). In archaea and eukaryotes, O-phosphoseryl-tRNA(Sec):selenocysteinyl-tRNA(Sec) synthase (SepSecS
Autor:
Miljan Simonović, Rachel L. French, Nicolas Doucet, Pratul K. Agarwal, Chitra Narayanan, Donald Gagné
Publikováno v:
Structure (London, England : 1993)
Structure (London, England : 1993), 2015, 23 (12), pp.2256-66. ⟨10.1016/j.str.2015.10.011⟩
Structure (London, England : 1993), 2015, 23 (12), pp.2256-66. ⟨10.1016/j.str.2015.10.011⟩
International audience; The role of internal dynamics in enzyme function is highly debated. Specifically, how small changes in structure far away from the reaction site alter protein dynamics and overall enzyme mechanisms is of wide interest in prote