Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Rachel L. Dusek"'
Autor:
Eugenio Gaudio, Chiara Tarantelli, Filippo Spriano, Francesca Guidetti, Giulio Sartori, Roberta Bordone, Alberto J. Arribas, Luciano Cascione, Mario Bigioni, Giuseppe Merlino, Alessio Fiascarelli, Alessandro Bressan, Afua Adjeiwaa Mensah, Gaetanina Golino, Renzo Lucchini, Elena Bernasconi, Davide Rossi, Emanuele Zucca, Georg Stussi, Anastasios Stathis, Robert S. Boyd, Rachel L. Dusek, Arnima Bisht, Nickolas Attanasio, Christian Rohlff, Andrea Pellacani, Monica Binaschi, Francesco Bertoni
Publikováno v:
Haematologica, Vol 105, Iss 11 (2020)
Antibody drug conjugates represent an important class of anti-cancer drugs in both solid tumors and hematological cancers. Here, we report preclinical data on the anti-tumor activity of the first-in-class antibody drug conjugate MEN1309/OBT076 target
Externí odkaz:
https://doaj.org/article/fd52bf5cbc7f444ba1538b1b0e104dc7
Autor:
Liliane, Robillard, Mingxiang, Liao, Minh, Nguyen, Thomas C, Harding, Andrew D, Simmons, Rachel L, Dusek
Publikováno v:
Journal of Immunotherapy. 45:335-348
Lucitanib is a multi-tyrosine kinase inhibitor whose targets are associated with angiogenesis and other key cancer and immune pathways. Its antiangiogenic properties are understood, but lucitanib's immunomodulatory activity is heretofore unknown. Luc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76b889b3648981c6d039cba99693f99c
https://doi.org/10.1097/cji.0000000000000427
https://doi.org/10.1097/cji.0000000000000427
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Table S1. Commercial tumor TMAs representing different solid tumor types. Supplementary Table S2. Summary of CD205 expression in human solid tumor types.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21cf7101ed534f43774d52ecead68615
https://doi.org/10.1158/1535-7163.22506906
https://doi.org/10.1158/1535-7163.22506906
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Figure S1. Representative images of IHC staining for CD205 in different human and cynomolgus tissues, obtained with 2 μg/ml of MEN1309/OBT076 at 20X and 10X magnification. 1) Human donor spleen; moderate to strong membranous/granular c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf7f557e3c0b13a225056116161e1ea2
https://doi.org/10.1158/1535-7163.22506924
https://doi.org/10.1158/1535-7163.22506924
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Table S5: Microscopic IHC staining for CD205 in different cynomolgus tissues after treatment with MEN1309/OBT076. Staining: 1, minimal (+, rare cells with low staining intensity); 2, slight/moderate (++, many cells with medium/high stai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d120dff76a7a69bed3c4755b84293b6
https://doi.org/10.1158/1535-7163.22506909.v1
https://doi.org/10.1158/1535-7163.22506909.v1
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Figure S3-A. Representative image of IHC staining for CD205 in a tumor mass from HCC-70 xenograft model, 16 days far from the initial treatment with 5 mg/kg of MEN1309/OBT076. The semiquantitative IHC analysis showed a score of 1+ in 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::409b3e8ea4192c7e05c7ae7eb15f6146
https://doi.org/10.1158/1535-7163.22506918
https://doi.org/10.1158/1535-7163.22506918
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
CD205 is a type I transmembrane glycoprotein and is a member of the C-type lectin receptor family. Analysis by mass spectrometry revealed that CD205 was robustly expressed and highly prevalent in a variety of solid malignancies from different histoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15a43cd253373afbccb5590a5dc6f77f
https://doi.org/10.1158/1535-7163.c.6538521.v1
https://doi.org/10.1158/1535-7163.c.6538521.v1
Autor:
Monica Binaschi, Andrea Pellacani, Stefano Manzini, Christian Rohlff, Keith E. Wilson, Jonathan Terrett, Carmel M. Lynch, Michael Trang, Dee Aud, Rahel Awdew, Phuoc Huy Pham, James E. Ackroyd, Rachel L. Dusek, San Lin Lou, Nickolas Attanasio, Sudha Swaminathan, Uyen T. Do, Robert Boyd, Angelo Kaplan, Arnima Bisht, Joaquin Arribas, Cristina Bernadó Morales, Rosanna Manno, Rossana Bugianesi, Massimiliano Salerno, Daniela Bellarosa, Corrado Carrisi, Alessandro Bressan, Mario Bigioni, Alessio Fiascarelli, Giuseppe Merlino
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0eec59be317dbf0230532db78f737319
https://doi.org/10.1158/1535-7163.22506927
https://doi.org/10.1158/1535-7163.22506927
Autor:
Chiara Tarantelli, Giulio Sartori, Emanuele Zucca, Monica Binaschi, Francesca Guidetti, Filippo Spriano, Renzo Lucchini, Gaetanina Golino, Anastasios Stathis, Roberta Pittau Bordone, Eugenio Gaudio, Georg Stussi, Rachel L. Dusek, Luciano Cascione, Alessandro Bressan, Davide Rossi, Christian Rohlff, Arnima Bisht, Mario Bigioni, Robert S. Boyd, Andrea Pellacani, Nickolas Attanasio, Francesco Bertoni, Afua Adjeiwaa Mensah, Merlino Giuseppe, Elena Bernasconi, Alessio Fiascarelli, Alberto J. Arribas
Publikováno v:
Haematologica
Antibody drug conjugates represent an important class of anti-cancer drugs in both solid tumors and hematological cancers. Here, we report preclinical data on the anti-tumor activity of the first-in-class antibody drug conjugate MEN1309/OBT076 target
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8afb9c94d4ea4eebb8e289cb102216b
https://doi.org/10.3324/haematol.2019.227215
https://doi.org/10.3324/haematol.2019.227215
Autor:
Giuseppe Merlino, Alessio Fiascarelli, Mario Bigioni, Alessandro Bressan, Corrado Carrisi, Daniela Bellarosa, Massimiliano Salerno, Rossana Bugianesi, Rosanna Manno, Cristina Bernadó Morales, Joaquin Arribas, Arnima Bisht, Angelo Kaplan, Robert Boyd, Uyen T. Do, Sudha Swaminathan, Nickolas Attanasio, San Lin Lou, Rachel L. Dusek, James E. Ackroyd, Phuoc Huy Pham, Rahel Awdew, Dee Aud, Michael Trang, Carmel M. Lynch, Jonathan Terrett, Keith E. Wilson, Christian Rohlff, Stefano Manzini, Andrea Pellacani, Monica Binaschi
Publikováno v:
Molecular Cancer Therapeutics. 18:1533-1543
CD205 is a type I transmembrane glycoprotein and is a member of the C-type lectin receptor family. Analysis by mass spectrometry revealed that CD205 was robustly expressed and highly prevalent in a variety of solid malignancies from different histoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58c2ad62495f674c64e1af852341e07f
https://doi.org/10.1158/1535-7163.mct-18-0624
https://doi.org/10.1158/1535-7163.mct-18-0624