Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Rachel L. Cowen"'
Autor:
Gabrielle M Finn, Chiu-Yi Lin, Cinzia Greco, Hema Radhakrishnan, Rachel L Cowen, Natalie J Gardiner
Publikováno v:
BMJ Open, Vol 14, Iss 3 (2024)
Objectives The aim of this study was to explore the barriers and facilitators faced by clinical academics (CAs) in the Greater Manchester region, with particular attention to the experiences of minoritised groups.Design A qualitative study using semi
Externí odkaz:
https://doaj.org/article/e78fae37125742f6bbc5c48d278d2207
Autor:
Amanda Eustace, D.G. Pearson, Chris J. Ottley, Michael J. Tilby, M Barathova, S Brittain-Dissont, Caroline Dive, Ian J. Stratford, Rachel L. Cowen, Kaye J. Williams, Darren L. Roberts
Publikováno v:
British Journal of Cancer
BACKGROUND: Hypoxia is as an indicator of poor treatment outcome. Consistently, hypoxic HCT116 colorectal cancer cells are resistant to oxaliplatin, although the mechanistic basis is unclear. This study sought to investigate the relative contribution
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a301d1d0ed1a99304de718c4a4382163
https://doi.org/10.1038/sj.bjc.6605311
https://doi.org/10.1038/sj.bjc.6605311
Publikováno v:
Molecular Cancer Therapeutics. 8:1261-1269
Tumor-associated macrophages (TAMs) are found in many solid tumors and have often been shown to accumulate in the hypoxic regions surrounding areas of necrosis. TAMs are the major site of expression of nitric oxide synthase (NOS), a heme-containing h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40180dea7790a1351c58bef0c3c3830a
https://doi.org/10.1158/1535-7163.mct-08-0927
https://doi.org/10.1158/1535-7163.mct-08-0927
Publikováno v:
Radiation Research. 171:572-580
Nitric oxide (NO) is a potent radiosensitizer of hypoxic mammalian cells. There have been many reports demonstrating radiosensitization in vitro and in vivo by the use of NO donors to generate NO by chemical means or by producing agents that mimic th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6466bef70eee8f8fdd9ee848e607f610
https://doi.org/10.1667/rr1640.1
https://doi.org/10.1667/rr1640.1
Publikováno v:
Clinical Oncology. 19:427-442
One of the key issues for radiobiologists is the importance of hypoxia to the radiotherapy response. This review addresses the reasons for this and primarily focuses on one aspect, the development of bioreductive drugs that are specifically designed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::545a253ed410be5822b31956c2838712
https://doi.org/10.1016/j.clon.2007.03.006
https://doi.org/10.1016/j.clon.2007.03.006
Autor:
Louisa M. Brown, Kaye J. Williams, Freda C. D. Sheppard, Camille Debray, Amanda Eustace, Janine T. Erler, Ian J. Stratford, Rachel L. Cowen, Catriona Parker
Publikováno v:
Molecular Pharmacology. 69:411-418
The resistance of hypoxic cells to conventional chemotherapy is well documented. Using both adenovirus-mediated gene delivery and small molecules targeting hypoxia-inducible factor-1 (HIF-1), we evaluated the impact of HIF-1 inhibition on the sensiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b05dbd3715255e1248e0c4d84c36c4d
https://doi.org/10.1124/mol.105.015743
https://doi.org/10.1124/mol.105.015743
Autor:
David J. Waxman, Youssef Jounaidi, Shairoz Ramji, Ian J. Stratford, Rachel L. Cowen, Charles S. Morrow, Adam V. Patterson, Chong-Sheng Chen, Ting Su, Kaye J. Williams, David S. Riddick, Alan J. Townsend, Chunja Lee, Pamela S. Schwartz, E Chinje, Hong Lu
Publikováno v:
Drug Metabolism and Disposition. 33:1083-1096
Drug-metabolizing enzymes and drug transporters are key determinants of the pharmacokinetics and pharmacodynamics of many antineoplastic agents. Metabolism and transport influence the cytotoxic effects of antineoplastic agents in target tumor cells a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59baefaa75d2e7fe5c3650261ba1802a
https://doi.org/10.1124/dmd.105.004374
https://doi.org/10.1124/dmd.105.004374
Autor:
Ian J. Stratford, Simon D. Scott, Adam V. Patterson, Freda C. D. Sheppard, Rachel L. Cowen, Suzanne Robinson, Naomi Chadderton, Kaye J. Williams, Olga Greco
Publikováno v:
International Journal of Radiation Oncology*Biology*Physics. 62:213-222
Purpose: Tumor hypoxia is unequivocally linked to poor radiotherapy outcome. This study aimed to identify enhancer sequences that respond maximally to a combination of radiation and hypoxia for use in genetic radiotherapy approaches. Methods and mate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7048ee800b492454d122774fc92c795
https://doi.org/10.1016/j.ijrobp.2005.01.031
https://doi.org/10.1016/j.ijrobp.2005.01.031
Autor:
Gareth J. Griffiths, Jane Barraclough, Arkadiusz Welman, Christopher Cawthorne, Judith C. Williams, Ian J. Stratford, Caroline Dive, Nigel K Smith, Rachel L. Cowen
Publikováno v:
Journal of Cellular Biochemistry. 94:1148-1162
Validation of targets for cancer drug discovery requires robust experimental models. Systems based on inducible gene expression are well suited to this purpose but are difficult to establish in several epithelial cell types. Using the recently discov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6d44940ffc16870bf6381f4a51123a
https://doi.org/10.1002/jcb.20342
https://doi.org/10.1002/jcb.20342
Autor:
E Chinje, Ian J. Stratford, Kaye J. Williams, Rachel L. Cowen, Freda C. D. Sheppard, Natasha S. Wind, Mohammed Jaffar, Brian A. Telfer
Publikováno v:
Cancer Research. 64:1396-1402
Solid tumors are characterized by regions of hypoxia that are inherently resistant to both radiotherapy and some chemotherapy. To target this resistant population, bioreductive drugs that are preferentially toxic to tumor cells in a hypoxic environme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58ef13c278c17a59f024017d616b9d36
https://doi.org/10.1158/0008-5472.can-03-2698
https://doi.org/10.1158/0008-5472.can-03-2698