Výsledky vyhledávání - "Rachel L. Berry"

Akademický článek

Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice

Autor: Rachel L. Berry, Derya D. Ozdemir, Bruce Aronow, Nils O. Lindström, Tatiana Dudnakova, Anna Thornburn, Paul Perry, Richard Baldock, Chris Armit, Anagha Joshi, Cécile Jeanpierre, Jingdong Shan, Seppo Vainio, James Baily, David Brownstein, Jamie Davies, Nicholas D. Hastie, Peter Hohenstein

Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 8, Pp 903-917 (2015)

Wilms' tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. The genetically best-defined subgroup of Wilms' tumours is the group caused by biallelic loss of the WT1 tumour supp

Externí odkaz: https://doaj.org/article/91a4163cc6854a4d936c53b9850ade29

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WT1 regulates the expression of inhibitory chemokines during heart development

Autor: Maurice J.B. van den Hoff, Manuel Reina, Rachel L. Berry, Nicholas D. Hastie, You-Ying Chau, Fernando O. Martinez, Joan Slight, Victor Velecela, Laura A. Lettice, Anna Thornburn, Ofelia M. Martínez-Estrada, Quinn D. Gunst

Publikováno v: Human molecular genetics, 22(25), 5083-5095. Oxford University Press

The embryonic epicardium is an important source of cardiovascular precursor cells and paracrine factors that are required for adequate heart formation. Signaling pathways regulated by WT1 that promote heart development have started to be described; h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1600ef4f4d0e21d84d41dc2b79435f59
https://doi.org/10.1093/hmg/ddt358

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Mutationally activated K-ras 4A and 4B both mediate lung carcinogenesis

Autor: Owen J. Sansom, Sarah J. Plowman, Mark J. Arends, David J. Harrison, Walter Kolch, William A Wallace, David G. Brownstein, Marion F Walker, Paul S. Devenney, Martin L. Hooper, Feijun Luo, Charles E. Patek, Rachel L. Berry, Lorraine Rose, Suzanne Hagan

Publikováno v: Experimental Cell Research. 314:1105-1114

To examine the roles of endogenous K-ras 4A and K-ras 4B splice variants in tumorigenesis, murine lung carcinogenesis was induced by N-methyl-N-nitrosourea (MNU), which causes a K-ras mutation (G12D) that jointly affects both isoforms. Compared with

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea85cb6d8d0b3c43bcf8e8226b981a4a
https://doi.org/10.1016/j.yexcr.2007.11.004

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The K-Ras 4A isoform promotes apoptosis but does not affect either lifespan or spontaneous tumor incidence in aging mice

Autor: Charles E. Patek, Rachel L. Berry, Ann-Marie Ritchie, Feijun Luo, Paul S. Devenney, Lorraine Rose, Sarah J. Plowman, Mark J. Arends, Martin L. Hooper, David G. Brownstein, David J. Harrison

Publikováno v: Experimental Cell Research. 312:16-26

Ras proteins function as molecular switches in signal transduction pathways, and, here, we examined the effects of the K-ras4A and 413 splice variants on cell function by comparing wild-type embryonic stem (ES) cells with K-ras(tm Delta 4A/tm Delta 4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682dd2878b7e4598409880436bbe227a
https://doi.org/10.1016/j.yexcr.2005.10.004

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Gonadal Effects of a Mouse Denys-Drash Syndrome Mutation

Autor: Rachel L. Berry, Charles E. Patek, Richard M. Sharpe, Colin G. Miles, Nicholas D. Hastie, Martin L. Hooper, Philippa T. K. Saunders

Publikováno v: Transgenic Research. 14:691-702

Gonadal effects of the Denys-Drash syndrome (DDS) mutation Wt1(tmT396 )were examined in chimaeric and heterozygous mice. Since the only heterozygote was 41,XXY, Sertoli cell function was assessed by comparison with age-matched control XXY testes. Con

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76a0d9cd0a4c94eb7aa31b81bf0446ba
https://doi.org/10.1007/s11248-005-7216-y

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Upregulation of Wilms' tumor gene 1 (WT1) in desmoid tumors

Autor: Rachel L. Berry, Adriana Bastidas, Ali Jadidizadeh, Sabine Tejpar, Bernadette Van der Schueren, Peter Hohenstein, Kim Van Dam, Saeid Amini Nik, Charles E. Patek, Jean-Jacques Cassiman

Publikováno v: International Journal of Cancer. 114:202-208

Desmoid tumors (aggressive fibromatosis) are locally invasive soft tissue tumors in which beta-catenin/TCF3 mediated Wnt signaling is activated. More than 80% of desmoid tumors contain activating mutations in beta-catenin. It has been shown that the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9971eed65dbfda3324f9a6de917e24f6
https://doi.org/10.1002/ijc.20717

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A self-avoidance mechanism in patterning of the urinary collecting duct tree

Autor: Jamie A. Davies, Rachel L. Berry, C-Hong Chang, Peter Hohenstein

Publikováno v: BMC Developmental Biology
Davies, J, Hohenstein, P, Chang, C-H & Berry, R 2014, ' A self-avoidance mechanism in patterning of the urinary collecting duct tree ', BMC Developmental Biology, vol. 14, 35 . https://doi.org/10.1186/s12861-014-0035-8

Background: Glandular organs require the development of a correctly patterned epithelial tree. These arise by iterative branching: early branches have a stereotyped anatomy, while subsequent branching is more flexible, branches spacing out to avoid e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5204f254dbe9c92b1567648d45a2a9f
https://doi.org/10.1186/s12861-014-0035-8

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Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

Autor: Roberto Bandiera, Martin Lee, Andreas Schedl, Sophie L. McHaffie, Wei Qing, Joan Slight, Alan Serrels, Ramón Muñoz Chápuli, Ofelia M. Martínez-Estrada, Anna Thornburn, You-Ying Chau, Brian R. Walker, Roland H Stimson, Rachel L. Berry, Nicholas D. Hastie

Publikováno v: Chau, Y-Y, Bandiera, R, Serrels, A, Martínez-Estrada, O M, Qing, W, Lee, M, Slight, J, Thornburn, A, Berry, R, McHaffie, S, Stimson, R H, Walker, B R, Chapuli, R M, Schedl, A & Hastie, N 2014, ' Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source ', Nature Cell Biology, vol. 16, no. 4, pp. 367-375 . https://doi.org/10.1038/ncb2922
Nature cell biology
Nature Cell Biology
Nature Cell Biology, Nature Publishing Group, 2014, epub ahead of print. ⟨10.1038/ncb2922⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname

International audience; : Fuelled by the obesity epidemic, there is considerable interest in the developmental origins of white adipose tissue (WAT) and the stem and progenitor cells from which it arises. Whereas increased visceral fat mass is associ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc9ce7d04e7e5ea8734ddf98e18bc16b
https://hdl.handle.net/20.500.11820/8f3ae81d-92fe-45f3-9ed2-b4e126b1748d

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Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla

Autor: Nicholas D. Hastie, Jamie A. Davies, David G. Brownstein, David R. FitzPatrick, Liming Pei, Allyson Ross, Rachel L. Berry, Louise Harewood, Peter Hohenstein, Malcolm E. Fisher, William A. Alaynick, Julie Moss, Ronald M. Evans

Publikováno v: Berry, R, Harewood, L, Pei, L, Fisher, M, Brownstein, D, Ross, A, Alaynick, W A, Moss, J, Hastie, N D, Hohenstein, P, Davies, J A, Evans, R M & FitzPatrick, D R 2011, ' Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla ', Human Molecular Genetics, vol. 20, no. 5, pp. 917-926 . https://doi.org/10.1093/hmg/ddq530
Human Molecular Genetics

Congenital anomalies of the kidney and urinary tract (CAKUTs) are common disorders of human development affecting the renal parechyma, renal pelvis, ureter, bladder and urethra; they show evidence of shared genetic aetiology, although the molecular b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::280ba34c38719736c6c74cbcd1b3e584
https://hdl.handle.net/20.500.11820/58284037-dede-4f99-a432-e5ee8e130bd7

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Calcium/NFAT signalling promotes early nephrogenesis

Autor: Anna Ferrer-Vaquer, Anna-Katerina Hadjantonakis, Nick Hastie, Peter Hohenstein, Rachel L. Berry, Sally F. Burn, Jamie A. Davies, Anna Webb

Publikováno v: Burn, S F, Webb, A, Berry, R L, Davies, J A, Ferrer-Vaquer, A, Hadjantonakis, A K, Hastie, N D & Hohenstein, P 2011, ' Calcium/NFAT signalling promotes early nephrogenesis ', Developmental Biology, vol. 352, no. 2, pp. 288-98 . https://doi.org/10.1016/j.ydbio.2011.01.033
Developmental Biology

A number of Wnt genes are expressed during, and are known to be essential for, early kidney development. It is typically assumed that their products will act through the canonical β-catenin signalling pathway. We have found evidence that suggests ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a4a41ef0b41c692cfa0360951e9e251
https://www.pure.ed.ac.uk/ws/files/8020832/Calcium_NFAT_signalling_promotes_early_nephrogenesis.pdf

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